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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus sp. 5B6
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45NADUniRule annotation1
Binding sitei96SubstrateUniRule annotation1
Binding sitei102SubstrateUniRule annotation1
Binding sitei109NADUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Active sitei189Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 26NADUniRule annotation6
Nucleotide bindingi132 – 134NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
ORF Names:MY7_2573Imported
OrganismiBacillus sp. 5B6Imported
Taxonomic identifieri1127743 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000005799 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphoserineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 156Ldh_1_NInterPro annotationAdd BLAST141
Domaini160 – 318Ldh_1_CInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

I2HU28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPKKEKRIM GKTRSKVSVI GAGFTGATTA FLTAQKELAD VVLVDIPQLE
60 70 80 90 100
NPTKGKALDM LEASPVQGFD AKITGTSNYE DTAGSDIVVI TAGIARKPGM
110 120 130 140 150
SRDDLVSTNE KIMRSVTREI VKYSPDCIIV VLTNPVDAMT YAVYKESGFP
160 170 180 190 200
KERVIGQSGV LDTARFRTFV AEELNLSVKD VTGFVLGGHG DDMVPLVRYS
210 220 230 240 250
YAGGIPLETL IPKDRLDAIV ERTRKGGGEI VNLLGNGSAY YAPAASLTEM
260 270 280 290 300
VEAILKDQRR VLPTIAYLEG EYGHEGIYLG VPTIIGGNGL EQIIELELTE
310 320
YEKAQLSKSV ESVKNVMKVL S
Length:321
Mass (Da):34,721
Last modified:July 11, 2012 - v1
Checksum:iA7C714FFA0B65040
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJST01000001 Genomic DNA. Translation: EIF14237.1.

Genome annotation databases

EnsemblBacteriaiEIF14237; EIF14237; MY7_2573.
PATRICifig|1127743.3.peg.2523.

Similar proteinsi

Entry informationi

Entry nameiI2HU28_9BACI
AccessioniPrimary (citable) accession number: I2HU28
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported