ID   I2GAD8_HUMAN            Unreviewed;       312 AA.
AC   I2GAD8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   03-MAY-2023, entry version 37.
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CCH27330.1};
DE   Flags: Fragment;
GN   Name=HLA-B {ECO:0000313|EMBL:CCH27330.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CCH27330.1};
RN   [1] {ECO:0000313|EMBL:CCH27330.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:CCH27330.1};
RA   Anholts J.D.H.;
RT   "6 new sequences found during routine HLA typing.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
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DR   EMBL; HE804040; CCH27330.1; -; Genomic_DNA.
DR   AlphaFoldDB; I2GAD8; -.
DR   PeptideAtlas; I2GAD8; -.
DR   ChiTaRS; HLA-B; human.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd21026; IgC1_MHC_Ia_HLA-B; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   PANTHER; PTHR16675:SF270; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B ALPHA CHAIN; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        283..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          184..270
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CCH27330.1"
FT   NON_TER         312
FT                   /evidence="ECO:0000313|EMBL:CCH27330.1"
SQ   SEQUENCE   312 AA;  35406 MW;  2DE014EAF8CDB724 CRC64;
     SHSMRYFDTA MSRPGRGEPR FISVGYVDDT QFVRFDSDAA SPREEPRAPW IEQEGPEYWD
     RNTQIFKTNT QTDRESLRNL RGYYNQSDAG SHTLQSMYGC DVGPDGRLLR GHNQYAYDGK
     DYIALNEDLR SWTAADTAAQ ITQRKWEAAR VAEQDRAYLE GTCVEWLRRY LENGKDTLER
     ADPPKTHVTH HPISDHEATL RCWALGFYPA EITLTWQRDG EDQTQDTELV ETRPAGDRTF
     QKWAAVVVPS GEEQRYTCHV QHEGLPKPLT LRWEPSSQST VPIVGIVAGL AVLAVVVIGA
     VVAAVMCRRK SS
//