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I2FA87

- I2FA87_HELCP

UniProt

I2FA87 - I2FA87_HELCP

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Protein
Alanine racemase
Gene
alr, HCN_0483
Organism
Helicobacter cinaedi (strain PAGU611)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei122 – 1221Substrate By similarityUniRule annotation
Active sitei257 – 2571Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei303 – 3031Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHCIN1172562:GLDZ-497-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HCN_0483Imported
OrganismiHelicobacter cinaedi (strain PAGU611)Imported
Taxonomic identifieri1172562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000001956: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2FA87.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiRIGYSGC.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2FA87-1 [UniParc]FASTAAdd to Basket

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MAEIILDSKA YKHNLNLIHS HINSHNKSNV EIAAVLKDNA YGHGLKEMAT    50
IAAEYGIKSV FVKNYNEAIQ IYKFFPQVTA FYGMPQGDFA KNIAFVIHDE 100
KHISALPQGT KVELKVNVGM NRNGIEPSEL ESFIQAILQK KLELIGVFSH 150
NGYGDDLDSV FFHTQSNFAK LKQEVLHLSQ KYGFAPPRFH SLSTSGAIRV 200
ASEGGITDDL VRIGIGAYGY LDVSFENPIS DKLQKVASLY ADRVSTRFLD 250
KGERIGYSGC TTLNSPQVVS TYDIGYGDGF FRVNENHKVY IANGLQILPR 300
SSMDCFSCFC DEPRICVFND VTHLAKAFGT ISYEILTHLS PSIKRTII 348
Length:348
Mass (Da):38,734
Last modified:July 11, 2012 - v1
Checksum:i292E4CB5404E63DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012344 Genomic DNA. Translation: BAM11775.1.
RefSeqiYP_006234886.1. NC_017761.1.

Genome annotation databases

EnsemblBacteriaiBAM11775; BAM11775; HCN_0483.
GeneIDi12763736.
KEGGihcp:HCN_0483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012344 Genomic DNA. Translation: BAM11775.1 .
RefSeqi YP_006234886.1. NC_017761.1.

3D structure databases

ProteinModelPortali I2FA87.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAM11775 ; BAM11775 ; HCN_0483 .
GeneIDi 12763736.
KEGGi hcp:HCN_0483.

Phylogenomic databases

KOi K01775.
OMAi RIGYSGC.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HCIN1172562:GLDZ-497-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Helicobacter cinaedi strain PAGU611 isolated from human bacteremia."
    Goto T., Ogura Y., Hirakawa H., Tomida J., Morita Y., Akaike T., Hayashi T., Kawamura Y.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PAGU611.

Entry informationi

Entry nameiI2FA87_HELCP
AccessioniPrimary (citable) accession number: I2FA87
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi