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I2FA87

- I2FA87_HELCP

UniProt

I2FA87 - I2FA87_HELCP

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Protein

Alanine racemase

Gene

alr

Organism
Helicobacter cinaedi (strain PAGU611)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Active sitei257 – 2571Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei303 – 3031Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHCIN1172562:GLDZ-497-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HCN_0483Imported
OrganismiHelicobacter cinaedi (strain PAGU611)Imported
Taxonomic identifieri1172562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000001956: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2FA87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiRIGYSGC.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2FA87-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEIILDSKA YKHNLNLIHS HINSHNKSNV EIAAVLKDNA YGHGLKEMAT
60 70 80 90 100
IAAEYGIKSV FVKNYNEAIQ IYKFFPQVTA FYGMPQGDFA KNIAFVIHDE
110 120 130 140 150
KHISALPQGT KVELKVNVGM NRNGIEPSEL ESFIQAILQK KLELIGVFSH
160 170 180 190 200
NGYGDDLDSV FFHTQSNFAK LKQEVLHLSQ KYGFAPPRFH SLSTSGAIRV
210 220 230 240 250
ASEGGITDDL VRIGIGAYGY LDVSFENPIS DKLQKVASLY ADRVSTRFLD
260 270 280 290 300
KGERIGYSGC TTLNSPQVVS TYDIGYGDGF FRVNENHKVY IANGLQILPR
310 320 330 340
SSMDCFSCFC DEPRICVFND VTHLAKAFGT ISYEILTHLS PSIKRTII
Length:348
Mass (Da):38,734
Last modified:July 11, 2012 - v1
Checksum:i292E4CB5404E63DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012344 Genomic DNA. Translation: BAM11775.1.
RefSeqiYP_006234886.1. NC_017761.1.

Genome annotation databases

EnsemblBacteriaiBAM11775; BAM11775; HCN_0483.
GeneIDi12763736.
KEGGihcp:HCN_0483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012344 Genomic DNA. Translation: BAM11775.1 .
RefSeqi YP_006234886.1. NC_017761.1.

3D structure databases

ProteinModelPortali I2FA87.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAM11775 ; BAM11775 ; HCN_0483 .
GeneIDi 12763736.
KEGGi hcp:HCN_0483.

Phylogenomic databases

KOi K01775.
OMAi RIGYSGC.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HCIN1172562:GLDZ-497-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Helicobacter cinaedi strain PAGU611 isolated from human bacteremia."
    Goto T., Ogura Y., Hirakawa H., Tomida J., Morita Y., Akaike T., Hayashi T., Kawamura Y.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PAGU611Imported.

Entry informationi

Entry nameiI2FA87_HELCP
AccessioniPrimary (citable) accession number: I2FA87
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 26, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3