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I2F2J5

- I2F2J5_9THEM

UniProt

I2F2J5 - I2F2J5_9THEM

Protein

Alanine racemase

Gene

Theba_0420

Organism
Mesotoga prima MesG1.Ag.4.2
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (11 Jul 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei36 – 361Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei131 – 1311SubstrateUniRule annotation
    Active sitei257 – 2571Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei305 – 3051Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMPRI660470:GLGB-420-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    ORF Names:Theba_0420Imported
    OrganismiMesotoga prima MesG1.Ag.4.2Imported
    Taxonomic identifieri660470 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeMesotoga
    ProteomesiUP000002881: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei36 – 361N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliI2F2J5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I2F2J5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSRKTFALI DLSAYRQNLV YLSGKASPAK LMVVVKADAY GHGAVELSKV    50
    AQESGVDRLA VAFLEEGIKI RQSGISLPIL VLNYVEKKEI PTAKEFSLTL 100
    SLSSFAQLEN IIGLNKQLPD FQLVVDTGMR RLGLEWEESI ELYNSAVRKG 150
    INITGAYTHF ATADEKGSGF VLEQREAFGR FLHGLGQRRN RHFETHISNS 200
    AGTIYFDNSD FSYVRAGIAT YGLQPSKETD ENLKPVLSWV SCVSFVKRIR 250
    TGYSVSYGRT FVADRDMLVA TIPVGYADGY NRLLSNRGYV IISGKRCKVL 300
    GRVCMDQFVV DISHIEKPVS IGDEVVIVGT QEGESISAEE IADLCGTINY 350
    EVVCSISSRV PRVYKKGVN 369
    Length:369
    Mass (Da):40,779
    Last modified:July 11, 2012 - v1
    Checksum:i2A4078CCB13646FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003532 Genomic DNA. Translation: AFK06148.1.
    RefSeqiYP_006345391.1. NC_017934.1.

    Genome annotation databases

    EnsemblBacteriaiAFK06148; AFK06148; Theba_0420.
    GeneIDi13029608.
    KEGGimpg:Theba_0420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003532 Genomic DNA. Translation: AFK06148.1 .
    RefSeqi YP_006345391.1. NC_017934.1.

    3D structure databases

    ProteinModelPortali I2F2J5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFK06148 ; AFK06148 ; Theba_0420 .
    GeneIDi 13029608.
    KEGGi mpg:Theba_0420.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MPRI660470:GLGB-420-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date."
      Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C., Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N., Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.
      Genome Biol. Evol. 4:700-708(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MesG1.Ag.4.2Imported.

    Entry informationi

    Entry nameiI2F2J5_9THEM
    AccessioniPrimary (citable) accession number: I2F2J5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2012
    Last sequence update: July 11, 2012
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3