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I2F2J5

- I2F2J5_9THEM

UniProt

I2F2J5 - I2F2J5_9THEM

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Protein

Alanine racemase

Gene

Theba_0420

Organism
Mesotoga prima MesG1.Ag.4.2
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei131 – 1311SubstrateUniRule annotation
Active sitei257 – 2571Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei305 – 3051Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMPRI660470:GLGB-420-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:Theba_0420Imported
OrganismiMesotoga prima MesG1.Ag.4.2Imported
Taxonomic identifieri660470 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeMesotoga
ProteomesiUP000002881: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2F2J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2F2J5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSRKTFALI DLSAYRQNLV YLSGKASPAK LMVVVKADAY GHGAVELSKV
60 70 80 90 100
AQESGVDRLA VAFLEEGIKI RQSGISLPIL VLNYVEKKEI PTAKEFSLTL
110 120 130 140 150
SLSSFAQLEN IIGLNKQLPD FQLVVDTGMR RLGLEWEESI ELYNSAVRKG
160 170 180 190 200
INITGAYTHF ATADEKGSGF VLEQREAFGR FLHGLGQRRN RHFETHISNS
210 220 230 240 250
AGTIYFDNSD FSYVRAGIAT YGLQPSKETD ENLKPVLSWV SCVSFVKRIR
260 270 280 290 300
TGYSVSYGRT FVADRDMLVA TIPVGYADGY NRLLSNRGYV IISGKRCKVL
310 320 330 340 350
GRVCMDQFVV DISHIEKPVS IGDEVVIVGT QEGESISAEE IADLCGTINY
360
EVVCSISSRV PRVYKKGVN
Length:369
Mass (Da):40,779
Last modified:July 11, 2012 - v1
Checksum:i2A4078CCB13646FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003532 Genomic DNA. Translation: AFK06148.1.
RefSeqiYP_006345391.1. NC_017934.1.

Genome annotation databases

EnsemblBacteriaiAFK06148; AFK06148; Theba_0420.
GeneIDi13029608.
KEGGimpg:Theba_0420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003532 Genomic DNA. Translation: AFK06148.1 .
RefSeqi YP_006345391.1. NC_017934.1.

3D structure databases

ProteinModelPortali I2F2J5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK06148 ; AFK06148 ; Theba_0420 .
GeneIDi 13029608.
KEGGi mpg:Theba_0420.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci MPRI660470:GLGB-420-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date."
    Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C., Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N., Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.
    Genome Biol. Evol. 4:700-708(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MesG1.Ag.4.2Imported.

Entry informationi

Entry nameiI2F2J5_9THEM
AccessioniPrimary (citable) accession number: I2F2J5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3