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Protein

Alanine racemase

Gene

Theba_0420

Organism
Mesotoga prima MesG1.Ag.4.2
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei131 – 1311SubstrateUniRule annotation
Active sitei257 – 2571Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei305 – 3051Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMPRI660470:GLGB-420-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:Theba_0420Imported
OrganismiMesotoga prima MesG1.Ag.4.2Imported
Taxonomic identifieri660470 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeMesotoga
ProteomesiUP000002881: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2F2J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2F2J5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSRKTFALI DLSAYRQNLV YLSGKASPAK LMVVVKADAY GHGAVELSKV
60 70 80 90 100
AQESGVDRLA VAFLEEGIKI RQSGISLPIL VLNYVEKKEI PTAKEFSLTL
110 120 130 140 150
SLSSFAQLEN IIGLNKQLPD FQLVVDTGMR RLGLEWEESI ELYNSAVRKG
160 170 180 190 200
INITGAYTHF ATADEKGSGF VLEQREAFGR FLHGLGQRRN RHFETHISNS
210 220 230 240 250
AGTIYFDNSD FSYVRAGIAT YGLQPSKETD ENLKPVLSWV SCVSFVKRIR
260 270 280 290 300
TGYSVSYGRT FVADRDMLVA TIPVGYADGY NRLLSNRGYV IISGKRCKVL
310 320 330 340 350
GRVCMDQFVV DISHIEKPVS IGDEVVIVGT QEGESISAEE IADLCGTINY
360
EVVCSISSRV PRVYKKGVN
Length:369
Mass (Da):40,779
Last modified:July 11, 2012 - v1
Checksum:i2A4078CCB13646FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003532 Genomic DNA. Translation: AFK06148.1.
RefSeqiYP_006345391.1. NC_017934.1.

Genome annotation databases

EnsemblBacteriaiAFK06148; AFK06148; Theba_0420.
GeneIDi13029608.
KEGGimpg:Theba_0420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003532 Genomic DNA. Translation: AFK06148.1.
RefSeqiYP_006345391.1. NC_017934.1.

3D structure databases

ProteinModelPortaliI2F2J5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFK06148; AFK06148; Theba_0420.
GeneIDi13029608.
KEGGimpg:Theba_0420.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMPRI660470:GLGB-420-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date."
    Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C., Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N., Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.
    Genome Biol. Evol. 4:700-708(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MesG1.Ag.4.2Imported.

Entry informationi

Entry nameiI2F2J5_9THEM
AccessioniPrimary (citable) accession number: I2F2J5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: February 4, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.