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Protein
Submitted name:

ATP-grasp enzyme, D-alanine-D-alanine ligase

Gene

Theba_0059

Organism
Mesotoga prima MesG1.Ag.4.2
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-grasp enzyme, D-alanine-D-alanine ligaseImported
Gene namesi
ORF Names:Theba_0059Imported
OrganismiMesotoga prima MesG1.Ag.4.2Imported
Taxonomic identifieri660470 [NCBI]
Taxonomic lineageiBacteriaThermotogaeKosmotogalesKosmotogaceaeMesotoga
Proteomesi
  • UP000002881 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi660470.ThebaDRAFT_1798.

Structurei

3D structure databases

ProteinModelPortaliI2F1K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 300ATP-graspInterPro annotationAdd BLAST205

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108N9N. Bacteria.
COG1181. LUCA.
KOiK01921.
OrthoDBiPOG091H1LUD.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011095. Dala_Dala_lig_C.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2F1K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRITVVHDTP LNLHHQEMVN SVVSSLEKIF EVDSRPFEID AVGRLRGTDL
60 70 80 90 100
VFNLTTAMGN TERQVHLPAV LDLLGIPFTG SGTTANALCI NKTLTKLIMK
110 120 130 140 150
AYGISTPEFF SVRPGETADN LPFSPAIVKP VKEGGAKGIW EDSVVESVDD
160 170 180 190 200
MQRAVSRIHE RFQQPALVER FIEGREFTVG IVGNEVLPIM EIDFSSLPDH
210 220 230 240 250
LETFYSYRVK QFHGDETNYI CPAKISRREE TVIREFSMRV FQVLDLKDYC
260 270 280 290 300
RIDLKIDDEG KIYFLEVNSL PLLVPDYSDI VKMAETRGWS YEDLINRIVA
310
SAIRRYGIGK ENGRV
Length:315
Mass (Da):35,659
Last modified:July 11, 2012 - v1
Checksum:i23F12BDF7D979F43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003532 Genomic DNA. Translation: AFK05810.1.
RefSeqiWP_014729984.1. NC_017934.1.

Genome annotation databases

EnsemblBacteriaiAFK05810; AFK05810; Theba_0059.
KEGGimpg:Theba_0059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003532 Genomic DNA. Translation: AFK05810.1.
RefSeqiWP_014729984.1. NC_017934.1.

3D structure databases

ProteinModelPortaliI2F1K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi660470.ThebaDRAFT_1798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFK05810; AFK05810; Theba_0059.
KEGGimpg:Theba_0059.

Phylogenomic databases

eggNOGiENOG4108N9N. Bacteria.
COG1181. LUCA.
KOiK01921.
OrthoDBiPOG091H1LUD.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011095. Dala_Dala_lig_C.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI2F1K7_9BACT
AccessioniPrimary (citable) accession number: I2F1K7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 30, 2016
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.