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Protein

D-alanine--D-alanine ligase

Gene

Emtol_3511

Organism
Emticicia oligotrophica (strain DSM 17448 / GPTSA100-15)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Emtol_3511Imported
OrganismiEmticicia oligotrophica (strain DSM 17448 / GPTSA100-15)Imported
Taxonomic identifieri929562 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeEmticicia
ProteomesiUP000002875 Componenti: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.
OMAiFKQMAEI.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2EY86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCYFLNGTL LAEPNCEQNL IMTNKIRVGV FFGGQARERE ISYLGGKTAF
60 70 80 90 100
EHIDKAIFEP VPIFVDSLGH FIQINPELLY EDSIRDFFPS KNLNRGFRVY
110 120 130 140 150
IESLGELNET QLYKLIYKVG KQVQPTDFSN LMDFAFVIMH GPQAEDGAIQ
160 170 180 190 200
GLLEWYGIPY MGPGLMGSAV GIDKPMQNKL LSLVTGQKKK MVTFTRDEWQ
210 220 230 240 250
VADRSKLFTD LINNIGFPFV VKAPHQGSSI GVAIVRKRSL EEFTKAIQQC
260 270 280 290 300
FFETTFLKRE WEKMTDRQKR HLMEKTSNLD EGIGFPLYVN GKILHHPAEL
310 320 330 340 350
MEELDALLFT LDSVTAISAN AEDHVMIEEF VVGQEFSCGV IQHDDGTALA
360 370 380 390 400
LPPTEIYGEI QTFDFKSKYK SNVTKKRIPV ETSIENLNKI HDNLLKAFNN
410 420 430 440 450
LGFSVVTRID GFLTPDSRVL LHDPNTLPGM SPASLIFKQM AEIGLTVTQS
460 470 480 490 500
ITYFVRQSIR ERIRSGKNTV ALRNLLEKID SLIEGRVSAH RKKVAIIFGE
510 520 530 540 550
TDEEYKTAQR KLGEYASSVA YEPVCVCAAR NGQMYKIPVN LMFKADIQDF
560 570 580 590 600
GQNIGKSKHP FIAEIIRKAE KITNKYAGSF DTQVKKLSET ELAESVQFIF
610
QCDSDTLVEL
Length:610
Mass (Da):68,960
Last modified:July 11, 2012 - v1
Checksum:i9DDBBA6E97192CF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002961 Genomic DNA. Translation: AFK04639.1.
RefSeqiYP_006874666.1. NC_018748.1.

Genome annotation databases

EnsemblBacteriaiAFK04639; AFK04639; Emtol_3511.
KEGGieol:Emtol_3511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002961 Genomic DNA. Translation: AFK04639.1.
RefSeqiYP_006874666.1. NC_018748.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFK04639; AFK04639; Emtol_3511.
KEGGieol:Emtol_3511.

Phylogenomic databases

KOiK01921.
OMAiFKQMAEI.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17448 / GPTSA100-15Imported.

Entry informationi

Entry nameiI2EY86_EMTOG
AccessioniPrimary (citable) accession number: I2EY86
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: April 1, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.