I2DPS2 (I2DPS2_9BURK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase, Monomeric isocitrate dehydrogenase EMBL AFJ86648.1

Gene names

ORF Names:

MYA_2288 EMBL AFJ86648.1

Organism

Burkholderia sp. KJ006 EMBL AFJ86648.1

Taxonomic identifier

416344 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	742 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	133 – 140	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	351	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	549	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	553	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	146	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	548	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	256	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	421	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	I2DPS2 [UniParc]. Last modified July 11, 2012. Version 1. Checksum: 3454ED5518C66C8C	FASTA	742	80,022
	10 20 30 40 50 60 MSTSPKIIYT LTDEAPALAT YSLLPIVKAF THSSGVAVET RDISLAGRII AAFADVLPPE 70 80 90 100 110 120 QKGSDDLADL GQLTLKPEAN IIKLPNISAS VPQLKAAIAE LQAQGYKLPA YPEEPSTDEE 130 140 150 160 170 180 KAVKARYDKI KGSAVNPVLR EGNSDRRAPL SVKNYARKHP HKMGAWKPTS KSHVAHMTDG 190 200 210 220 230 240 DFYGSEKSAL IADAGSVKIE LTTTDGVKKV LKEKTAVKAG EVIDASVMSR KALRSFIEAQ 250 260 270 280 290 300 IADAKAQDVL FSVHLKATMM KVSDPIMFGH FVSVFYGDVL AKHADVLAQA GFNPNNGIGD 310 320 330 340 350 360 LYARLKDLPA DTREAIEADI KAEYAVRPRL AMVNSDKGIT NLHVPSDVIV DASMPAMIRD 370 380 390 400 410 420 SGGMWGVDGQ LHDAKAVIPD RCYAGVYQAV IEDCKQHGAF DPVTMGSVPN VGLMAQAAEE 430 440 450 460 470 480 YGSHDKTFLI PADGVVRVTD EAGNVLLEHA VESGDIWRMC QTKDAPVQDW VKLAVNRARA 490 500 510 520 530 540 TGAPAVFWLD PVRAHDAQII AKVERYLKDH DTNGLDIRIM TPVDATRFSL ERIRAGKDTI 550 560 570 580 590 600 SVTGNVLRDY LTDLFPIMEL GTSAKMLSIV PLMAGGGMFE TGAGGSAPKH VQQFVEEGFL 610 620 630 640 650 660 RWDSLGEFLA LAASLEHLGN AYHNPKALVL AKTLDRATGK FLDENRSPAR KVGGIDNRGS 670 680 690 700 710 720 HFYLCMYWAQ ALAEQTEDAA LKAQFEGVAK SLADNEARIL EELGAAQGKA QAIGGYYRPD 730 740 VALTSQAMRP SATLNAIVDA VA

References

[1]	"Complete Genome Sequence of the Endophytic Bacterium Burkholderia sp. Strain KJ006." Kwak M.J., Song J.Y., Kim S.Y., Jeong H., Kang S.G., Kim B.K., Kwon S.K., Lee C.H., Yu D.S., Park S.H., Kim J.F. J. Bacteriol. 194:4432-4433(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: KJ006 EMBL AFJ86648.1.
[2]	Kwak M.-J., Song J.Y., Kim S.-Y., Jeong H., Kim B.K., Kwon S.-K., Lee C.H., Yu D.S., Park S.-H., Kim J.F. Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: KJ006 EMBL AFJ86648.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003514 Genomic DNA. Translation: AFJ86648.1.
RefSeq	YP_006333379.1. NC_017920.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AFJ86648; AFJ86648; MYA_2288.
GeneID	12968695.
KEGG	buk:MYA_2288.
Phylogenomic databases
KO	K00031.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

I2DPS2_9BURK

Accession

Primary (citable) accession number: I2DPS2

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2012
Last sequence update:	July 11, 2012
Last modified:	April 3, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)