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I2DGK7

- I2DGK7_HELPX

UniProt

I2DGK7 - I2DGK7_HELPX

Protein

Alanine racemase

Gene

MWE_1098

Organism
Helicobacter pylori XZ274
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (11 Jul 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei137 – 1371SubstrateUniRule annotation
    Active sitei273 – 2731Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei321 – 3211Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHPYL1127122:GLEU-1007-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    ORF Names:MWE_1098Imported
    OrganismiHelicobacter pylori XZ274Imported
    Taxonomic identifieri1127122 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000002882: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliI2DGK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I2DGK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMLKRASFV EVNSASLRHN FSTVKSIVSK DAHIMAVVKA NAYGAGAIKA    50
    SEIFLQEGAH YLGVATLDEA LELRSHFSKT PILILGYSPN SNASMLIDND 100
    LSTMIFSLEQ AEVFSQMALK SQKRLKVHLK IDTGMHRLGL EPNFKSIETI 150
    KKIRALKGLE VEGIFTHLSN ADAKIKTHAK NQMKAFNAFL EQLLNQKIEF 200
    QYRHAYNSAG ILSLCNGNEN RFLNLYRPGI MLYGFYPSNG MKETCPTILK 250
    NVISLKAQIV QIRSVKKGEF IGYGEHFYTN EETLVGVLAL GYADGLMRAL 300
    GNRIQVAINN QLAPLIGKVC MDQCFVKLNN IQAKEGDEVI LFGDKSAKAN 350
    DASEIAALLN TIPYETISTL SKRLERVYI 379
    Length:379
    Mass (Da):42,072
    Last modified:July 11, 2012 - v1
    Checksum:iBF90501E0D8ED3CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003419 Genomic DNA. Translation: AFJ81873.1.
    RefSeqiWP_000525614.1. NC_017926.1.
    YP_006338564.1. NC_017926.1.

    Genome annotation databases

    EnsemblBacteriaiAFJ81873; AFJ81873; MWE_1098.
    GeneIDi12973925.
    KEGGihey:MWE_1098.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003419 Genomic DNA. Translation: AFJ81873.1 .
    RefSeqi WP_000525614.1. NC_017926.1.
    YP_006338564.1. NC_017926.1.

    3D structure databases

    ProteinModelPortali I2DGK7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFJ81873 ; AFJ81873 ; MWE_1098 .
    GeneIDi 12973925.
    KEGGi hey:MWE_1098.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci HPYL1127122:GLEU-1007-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of Helicobacter pylori strain XZ274, an isolate from a tibetan patient with gastric cancer in China."
      Guo Y., Wang H., Li Y., Song Y., Chen C., Liao Y., Ren L., Guo C., Tong W., Shen W., Chen M., Mao X., Guo G., Zou Q.
      J. Bacteriol. 194:4146-4147(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: XZ274Imported.

    Entry informationi

    Entry nameiI2DGK7_HELPX
    AccessioniPrimary (citable) accession number: I2DGK7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2012
    Last sequence update: July 11, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3