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I2DGK7

- I2DGK7_HELPX

UniProt

I2DGK7 - I2DGK7_HELPX

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Protein
Alanine racemase
Gene
MWE_1098
Organism
Helicobacter pylori XZ274
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei137 – 1371Substrate By similarityUniRule annotation
Active sitei273 – 2731Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei321 – 3211Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHPYL1127122:GLEU-1007-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:MWE_1098Imported
OrganismiHelicobacter pylori XZ274Imported
Taxonomic identifieri1127122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002882: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2DGK7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2DGK7-1 [UniParc]FASTAAdd to Basket

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MGMLKRASFV EVNSASLRHN FSTVKSIVSK DAHIMAVVKA NAYGAGAIKA    50
SEIFLQEGAH YLGVATLDEA LELRSHFSKT PILILGYSPN SNASMLIDND 100
LSTMIFSLEQ AEVFSQMALK SQKRLKVHLK IDTGMHRLGL EPNFKSIETI 150
KKIRALKGLE VEGIFTHLSN ADAKIKTHAK NQMKAFNAFL EQLLNQKIEF 200
QYRHAYNSAG ILSLCNGNEN RFLNLYRPGI MLYGFYPSNG MKETCPTILK 250
NVISLKAQIV QIRSVKKGEF IGYGEHFYTN EETLVGVLAL GYADGLMRAL 300
GNRIQVAINN QLAPLIGKVC MDQCFVKLNN IQAKEGDEVI LFGDKSAKAN 350
DASEIAALLN TIPYETISTL SKRLERVYI 379
Length:379
Mass (Da):42,072
Last modified:July 11, 2012 - v1
Checksum:iBF90501E0D8ED3CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003419 Genomic DNA. Translation: AFJ81873.1.
RefSeqiWP_000525614.1. NC_017926.1.
YP_006338564.1. NC_017926.1.

Genome annotation databases

EnsemblBacteriaiAFJ81873; AFJ81873; MWE_1098.
GeneIDi12973925.
KEGGihey:MWE_1098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003419 Genomic DNA. Translation: AFJ81873.1 .
RefSeqi WP_000525614.1. NC_017926.1.
YP_006338564.1. NC_017926.1.

3D structure databases

ProteinModelPortali I2DGK7.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFJ81873 ; AFJ81873 ; MWE_1098 .
GeneIDi 12973925.
KEGGi hey:MWE_1098.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HPYL1127122:GLEU-1007-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Helicobacter pylori strain XZ274, an isolate from a tibetan patient with gastric cancer in China."
    Guo Y., Wang H., Li Y., Song Y., Chen C., Liao Y., Ren L., Guo C., Tong W., Shen W., Chen M., Mao X., Guo G., Zou Q.
    J. Bacteriol. 194:4146-4147(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XZ274Imported.

Entry informationi

Entry nameiI2DGK7_HELPX
AccessioniPrimary (citable) accession number: I2DGK7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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