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I2DGK7

- I2DGK7_HELPX

UniProt

I2DGK7 - I2DGK7_HELPX

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Protein

Alanine racemase

Gene

MWE_1098

Organism
Helicobacter pylori XZ274
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei137 – 1371SubstrateUniRule annotation
Active sitei273 – 2731Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei321 – 3211Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL1127122:GLEU-1007-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:MWE_1098Imported
OrganismiHelicobacter pylori XZ274Imported
Taxonomic identifieri1127122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002882: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2DGK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2DGK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGMLKRASFV EVNSASLRHN FSTVKSIVSK DAHIMAVVKA NAYGAGAIKA
60 70 80 90 100
SEIFLQEGAH YLGVATLDEA LELRSHFSKT PILILGYSPN SNASMLIDND
110 120 130 140 150
LSTMIFSLEQ AEVFSQMALK SQKRLKVHLK IDTGMHRLGL EPNFKSIETI
160 170 180 190 200
KKIRALKGLE VEGIFTHLSN ADAKIKTHAK NQMKAFNAFL EQLLNQKIEF
210 220 230 240 250
QYRHAYNSAG ILSLCNGNEN RFLNLYRPGI MLYGFYPSNG MKETCPTILK
260 270 280 290 300
NVISLKAQIV QIRSVKKGEF IGYGEHFYTN EETLVGVLAL GYADGLMRAL
310 320 330 340 350
GNRIQVAINN QLAPLIGKVC MDQCFVKLNN IQAKEGDEVI LFGDKSAKAN
360 370
DASEIAALLN TIPYETISTL SKRLERVYI
Length:379
Mass (Da):42,072
Last modified:July 11, 2012 - v1
Checksum:iBF90501E0D8ED3CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003419 Genomic DNA. Translation: AFJ81873.1.
RefSeqiYP_006338564.1. NC_017926.1.

Genome annotation databases

EnsemblBacteriaiAFJ81873; AFJ81873; MWE_1098.
GeneIDi12973925.
KEGGihey:MWE_1098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003419 Genomic DNA. Translation: AFJ81873.1 .
RefSeqi YP_006338564.1. NC_017926.1.

3D structure databases

ProteinModelPortali I2DGK7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFJ81873 ; AFJ81873 ; MWE_1098 .
GeneIDi 12973925.
KEGGi hey:MWE_1098.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HPYL1127122:GLEU-1007-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Helicobacter pylori strain XZ274, an isolate from a tibetan patient with gastric cancer in China."
    Guo Y., Wang H., Li Y., Song Y., Chen C., Liao Y., Ren L., Guo C., Tong W., Shen W., Chen M., Mao X., Guo G., Zou Q.
    J. Bacteriol. 194:4146-4147(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XZ274Imported.

Entry informationi

Entry nameiI2DGK7_HELPX
AccessioniPrimary (citable) accession number: I2DGK7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3