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I2B0X3

- I2B0X3_FRANT

UniProt

I2B0X3 - I2B0X3_FRANT

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Protein
Thymidine kinase
Gene
tdk, OOM_1711
Organism
Francisella noatunensis subsp. orientalis (strain Toba 04)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi147 – 1471Zinc By similarityUniRule annotation
Metal bindingi187 – 1871Zinc By similarityUniRule annotation
Metal bindingi190 – 1901Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi87 – 904ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciFNOA1163389:GLDE-1748-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:OOM_1711Imported
OrganismiFrancisella noatunensis subsp. orientalis (strain Toba 04)Imported
Taxonomic identifieri1163389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002869: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

I2B0X3-1 [UniParc]FASTAAdd to Basket

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MAKLYFRYSA MDAGKTLDLL KVTYNYEDRG RKPLVLTSAI DKRAGLNKVK    50
SRIGIDQDAY SLTDQDNIFE FVKDYNEKHK VDCVLIDEIH FFTQEQVWQL 100
SDIADQLDIP VICYGLRTNY LGQPFETAAL LLAIADTLEE VKTICHCGKK 150
ASFNMMVQNG KAIKEGNPIV VDDNSLKDID TRYVSVCRKH WKKGEYQ 197
Length:197
Mass (Da):22,584
Last modified:July 11, 2012 - v1
Checksum:i287C69AB61F9ABD9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003402 Genomic DNA. Translation: AFJ44070.1.
RefSeqiWP_014715595.1. NC_017909.1.
YP_006317546.1. NC_017909.1.

Genome annotation databases

EnsemblBacteriaiAFJ44070; AFJ44070; OOM_1711.
GeneIDi12952623.
KEGGifna:OOM_1711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003402 Genomic DNA. Translation: AFJ44070.1 .
RefSeqi WP_014715595.1. NC_017909.1.
YP_006317546.1. NC_017909.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFJ44070 ; AFJ44070 ; OOM_1711 .
GeneIDi 12952623.
KEGGi fna:OOM_1711.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci FNOA1163389:GLDE-1748-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome characterisation of Francisella noatunensis subsp. orientalis."
    Jonassen I., Nilsen F., Sridhar S., Sharma A., Kongshaug H.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toba 04Imported.

Entry informationi

Entry nameiI2B0X3_FRANT
AccessioniPrimary (citable) accession number: I2B0X3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 3, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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