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Protein

Thymidine kinase

Gene

tdk

Organism
Francisella noatunensis subsp. orientalis (strain Toba 04)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1
Metal bindingi190ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi87 – 90ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:OOM_1711Imported
OrganismiFrancisella noatunensis subsp. orientalis (strain Toba 04)Imported
Taxonomic identifieri1163389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000002869 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiKEQFGWI.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

I2B0X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFRYSA MDAGKTLDLL KVTYNYEDRG RKPLVLTSAI DKRAGLNKVK
60 70 80 90 100
SRIGIDQDAY SLTDQDNIFE FVKDYNEKHK VDCVLIDEIH FFTQEQVWQL
110 120 130 140 150
SDIADQLDIP VICYGLRTNY LGQPFETAAL LLAIADTLEE VKTICHCGKK
160 170 180 190
ASFNMMVQNG KAIKEGNPIV VDDNSLKDID TRYVSVCRKH WKKGEYQ
Length:197
Mass (Da):22,584
Last modified:July 11, 2012 - v1
Checksum:i287C69AB61F9ABD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003402 Genomic DNA. Translation: AFJ44070.1.
RefSeqiWP_014715595.1. NC_017909.1.

Genome annotation databases

EnsemblBacteriaiAFJ44070; AFJ44070; OOM_1711.
KEGGifna:OOM_1711.
PATRICifig|1163389.3.peg.2097.

Similar proteinsi

Entry informationi

Entry nameiI2B0X3_FRANT
AccessioniPrimary (citable) accession number: I2B0X3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 22, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported