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I2B0X3

- I2B0X3_FRANT

UniProt

I2B0X3 - I2B0X3_FRANT

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Protein

Thymidine kinase

Gene

tdk

Organism
Francisella noatunensis subsp. orientalis (strain Toba 04)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Metal bindingi187 – 1871ZincUniRule annotation
Metal bindingi190 – 1901ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi87 – 904ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciFNOA1163389:GLDE-1748-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:OOM_1711Imported
OrganismiFrancisella noatunensis subsp. orientalis (strain Toba 04)Imported
Taxonomic identifieri1163389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002869: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

I2B0X3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLYFRYSA MDAGKTLDLL KVTYNYEDRG RKPLVLTSAI DKRAGLNKVK
60 70 80 90 100
SRIGIDQDAY SLTDQDNIFE FVKDYNEKHK VDCVLIDEIH FFTQEQVWQL
110 120 130 140 150
SDIADQLDIP VICYGLRTNY LGQPFETAAL LLAIADTLEE VKTICHCGKK
160 170 180 190
ASFNMMVQNG KAIKEGNPIV VDDNSLKDID TRYVSVCRKH WKKGEYQ
Length:197
Mass (Da):22,584
Last modified:July 11, 2012 - v1
Checksum:i287C69AB61F9ABD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003402 Genomic DNA. Translation: AFJ44070.1.
RefSeqiWP_014715595.1. NC_017909.1.
YP_006317546.1. NC_017909.1.

Genome annotation databases

EnsemblBacteriaiAFJ44070; AFJ44070; OOM_1711.
GeneIDi12952623.
KEGGifna:OOM_1711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003402 Genomic DNA. Translation: AFJ44070.1 .
RefSeqi WP_014715595.1. NC_017909.1.
YP_006317546.1. NC_017909.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFJ44070 ; AFJ44070 ; OOM_1711 .
GeneIDi 12952623.
KEGGi fna:OOM_1711.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci FNOA1163389:GLDE-1748-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome characterisation of Francisella noatunensis subsp. orientalis."
    Jonassen I., Nilsen F., Sridhar S., Sharma A., Kongshaug H.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toba 04Imported.

Entry informationi

Entry nameiI2B0X3_FRANT
AccessioniPrimary (citable) accession number: I2B0X3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 26, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3