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Protein

Alanine racemase

Gene

alr

Organism
Mycobacterium sp. MOTT36Y
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei145 – 1451SubstrateUniRule annotation
Active sitei276 – 2761Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei324 – 3241Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMSP1168287:GLGR-4262-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:W7S_21280Imported
OrganismiMycobacterium sp. MOTT36YImported
Taxonomic identifieri1168287 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000002868 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2AIT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2AIT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRAATPIS LTPGLLAEAL VDLGAIAHNV RLLCEQAGGA QVMAVVKADG
60 70 80 90 100
YGHGAAQTAR AALAAGAAEL GVATVDEALA LRADGVRAPV LAWLHPPGFD
110 120 130 140 150
FAPALLADIQ IAVSSERQLD ELLDAVRRTG RTATVTVKVD TGLNRNGVPP
160 170 180 190 200
EHYPSMLTAL RRAVAENAIV LRGLMSHMVY ADQPANPVND LQAQRFTEML
210 220 230 240 250
AQARDQGVRY EAAHLSNSSA TMSRPDLAFD MVRPGIAVYG LSPVPELGDM
260 270 280 290 300
GLIPAMTVKC PVALVKSIRA GESVSYGHTW TARRDTTLAL LPVGYADGVF
310 320 330 340 350
RSLGNRLEVL INGRRRPGVG RICMDQFVVD LGPGPTDVAE GDEAILFGPG
360 370 380 390
ASGEPTAQDW ADLLGTIHYE VVTSPRGRIT RTYREARTIE P
Length:391
Mass (Da):41,404
Last modified:July 11, 2012 - v1
Checksum:i84AF306C9AB1199C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003491 Genomic DNA. Translation: AFJ37205.1.
RefSeqiWP_014712323.1. NC_017904.1.
YP_006307932.1. NC_017904.1.

Genome annotation databases

EnsemblBacteriaiAFJ37205; AFJ37205; W7S_21280.
KEGGimmm:W7S_21280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003491 Genomic DNA. Translation: AFJ37205.1.
RefSeqiWP_014712323.1. NC_017904.1.
YP_006307932.1. NC_017904.1.

3D structure databases

ProteinModelPortaliI2AIT1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFJ37205; AFJ37205; W7S_21280.
KEGGimmm:W7S_21280.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMSP1168287:GLGR-4262-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Mycobacterium intracellulare clinical strain MOTT-36Y, belonging to the INT5 genotype."
    Kim B.J., Choi B.S., Choi I.Y., Lee J.H., Chun J., Hong S.H., Kook Y.H., Kim B.J.
    J. Bacteriol. 194:4141-4142(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MOTT36YImported.

Entry informationi

Entry nameiI2AIT1_9MYCO
AccessioniPrimary (citable) accession number: I2AIT1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: April 1, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.