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I2AIT1

- I2AIT1_9MYCO

UniProt

I2AIT1 - I2AIT1_9MYCO

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Protein

Alanine racemase

Gene

alr

Organism
Mycobacterium sp. MOTT36Y
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei145 – 1451SubstrateUniRule annotation
Active sitei276 – 2761Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei324 – 3241Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMSP1168287:GLGR-4262-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:W7S_21280Imported
OrganismiMycobacterium sp. MOTT36YImported
Taxonomic identifieri1168287 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000002868: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2AIT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I2AIT1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGRAATPIS LTPGLLAEAL VDLGAIAHNV RLLCEQAGGA QVMAVVKADG
60 70 80 90 100
YGHGAAQTAR AALAAGAAEL GVATVDEALA LRADGVRAPV LAWLHPPGFD
110 120 130 140 150
FAPALLADIQ IAVSSERQLD ELLDAVRRTG RTATVTVKVD TGLNRNGVPP
160 170 180 190 200
EHYPSMLTAL RRAVAENAIV LRGLMSHMVY ADQPANPVND LQAQRFTEML
210 220 230 240 250
AQARDQGVRY EAAHLSNSSA TMSRPDLAFD MVRPGIAVYG LSPVPELGDM
260 270 280 290 300
GLIPAMTVKC PVALVKSIRA GESVSYGHTW TARRDTTLAL LPVGYADGVF
310 320 330 340 350
RSLGNRLEVL INGRRRPGVG RICMDQFVVD LGPGPTDVAE GDEAILFGPG
360 370 380 390
ASGEPTAQDW ADLLGTIHYE VVTSPRGRIT RTYREARTIE P
Length:391
Mass (Da):41,404
Last modified:July 11, 2012 - v1
Checksum:i84AF306C9AB1199C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003491 Genomic DNA. Translation: AFJ37205.1.
RefSeqiWP_014712323.1. NC_017904.1.
YP_006307932.1. NC_017904.1.

Genome annotation databases

EnsemblBacteriaiAFJ37205; AFJ37205; W7S_21280.
GeneIDi12939497.
KEGGimmm:W7S_21280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003491 Genomic DNA. Translation: AFJ37205.1 .
RefSeqi WP_014712323.1. NC_017904.1.
YP_006307932.1. NC_017904.1.

3D structure databases

ProteinModelPortali I2AIT1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFJ37205 ; AFJ37205 ; W7S_21280 .
GeneIDi 12939497.
KEGGi mmm:W7S_21280.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci MSP1168287:GLGR-4262-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Mycobacterium intracellulare clinical strain MOTT-36Y, belonging to the INT5 genotype."
    Kim B.J., Choi B.S., Choi I.Y., Lee J.H., Chun J., Hong S.H., Kook Y.H., Kim B.J.
    J. Bacteriol. 194:4141-4142(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MOTT36YImported.

Entry informationi

Entry nameiI2AIT1_9MYCO
AccessioniPrimary (citable) accession number: I2AIT1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3