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I2AIT1 (I2AIT1_9MYCO) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 RuleBase RU004247 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site471Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2761Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1451Substrate By similarity HAMAP-Rule MF_01201
Binding site3241Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue471N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
I2AIT1 [UniParc].

Last modified July 11, 2012. Version 1.
Checksum: 84AF306C9AB1199C

FASTA39141,404
        10         20         30         40         50         60 
MTGRAATPIS LTPGLLAEAL VDLGAIAHNV RLLCEQAGGA QVMAVVKADG YGHGAAQTAR 

        70         80         90        100        110        120 
AALAAGAAEL GVATVDEALA LRADGVRAPV LAWLHPPGFD FAPALLADIQ IAVSSERQLD 

       130        140        150        160        170        180 
ELLDAVRRTG RTATVTVKVD TGLNRNGVPP EHYPSMLTAL RRAVAENAIV LRGLMSHMVY 

       190        200        210        220        230        240 
ADQPANPVND LQAQRFTEML AQARDQGVRY EAAHLSNSSA TMSRPDLAFD MVRPGIAVYG 

       250        260        270        280        290        300 
LSPVPELGDM GLIPAMTVKC PVALVKSIRA GESVSYGHTW TARRDTTLAL LPVGYADGVF 

       310        320        330        340        350        360 
RSLGNRLEVL INGRRRPGVG RICMDQFVVD LGPGPTDVAE GDEAILFGPG ASGEPTAQDW 

       370        380        390 
ADLLGTIHYE VVTSPRGRIT RTYREARTIE P 

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References

[1]"Complete genome sequence of Mycobacterium intracellulare clinical strain MOTT-36Y, belonging to the INT5 genotype."
Kim B.J., Choi B.S., Choi I.Y., Lee J.H., Chun J., Hong S.H., Kook Y.H., Kim B.J.
J. Bacteriol. 194:4141-4142(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT36Y EMBL AFJ37205.1.
[2]Kim B.-J., Choi B.-S., Lim J.-S., Choi I.-Y., Kook Y.-H., Kim B.-J.
Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT36Y EMBL AFJ37205.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003491 Genomic DNA. Translation: AFJ37205.1.
RefSeqYP_006307932.1. NC_017904.1.

3D structure databases

ProteinModelPortalI2AIT1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFJ37205; AFJ37205; W7S_21280.
GeneID12939497.
KEGGmmm:W7S_21280.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.

Enzyme and pathway databases

BioCycMSP1168287:GLGR-4262-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI2AIT1_9MYCO
AccessionPrimary (citable) accession number: I2AIT1
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)