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I2AIT1

- I2AIT1_9MYCO

UniProt

I2AIT1 - I2AIT1_9MYCO

Protein

Alanine racemase

Gene

alr

Organism
Mycobacterium sp. MOTT36Y
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (11 Jul 2012)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei47 – 471Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation
    Active sitei276 – 2761Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei324 – 3241Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMSP1168287:GLGR-4262-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    ORF Names:W7S_21280Imported
    OrganismiMycobacterium sp. MOTT36YImported
    Taxonomic identifieri1168287 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000002868: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliI2AIT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I2AIT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGRAATPIS LTPGLLAEAL VDLGAIAHNV RLLCEQAGGA QVMAVVKADG    50
    YGHGAAQTAR AALAAGAAEL GVATVDEALA LRADGVRAPV LAWLHPPGFD 100
    FAPALLADIQ IAVSSERQLD ELLDAVRRTG RTATVTVKVD TGLNRNGVPP 150
    EHYPSMLTAL RRAVAENAIV LRGLMSHMVY ADQPANPVND LQAQRFTEML 200
    AQARDQGVRY EAAHLSNSSA TMSRPDLAFD MVRPGIAVYG LSPVPELGDM 250
    GLIPAMTVKC PVALVKSIRA GESVSYGHTW TARRDTTLAL LPVGYADGVF 300
    RSLGNRLEVL INGRRRPGVG RICMDQFVVD LGPGPTDVAE GDEAILFGPG 350
    ASGEPTAQDW ADLLGTIHYE VVTSPRGRIT RTYREARTIE P 391
    Length:391
    Mass (Da):41,404
    Last modified:July 11, 2012 - v1
    Checksum:i84AF306C9AB1199C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003491 Genomic DNA. Translation: AFJ37205.1.
    RefSeqiWP_014712323.1. NC_017904.1.
    YP_006307932.1. NC_017904.1.

    Genome annotation databases

    EnsemblBacteriaiAFJ37205; AFJ37205; W7S_21280.
    GeneIDi12939497.
    KEGGimmm:W7S_21280.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003491 Genomic DNA. Translation: AFJ37205.1 .
    RefSeqi WP_014712323.1. NC_017904.1.
    YP_006307932.1. NC_017904.1.

    3D structure databases

    ProteinModelPortali I2AIT1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFJ37205 ; AFJ37205 ; W7S_21280 .
    GeneIDi 12939497.
    KEGGi mmm:W7S_21280.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MSP1168287:GLGR-4262-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Mycobacterium intracellulare clinical strain MOTT-36Y, belonging to the INT5 genotype."
      Kim B.J., Choi B.S., Choi I.Y., Lee J.H., Chun J., Hong S.H., Kook Y.H., Kim B.J.
      J. Bacteriol. 194:4141-4142(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MOTT36YImported.

    Entry informationi

    Entry nameiI2AIT1_9MYCO
    AccessioniPrimary (citable) accession number: I2AIT1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2012
    Last sequence update: July 11, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3