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I2AH34 (I2AH34_9MYCO) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFJ36608.1
ORF Names:W7S_18265 EMBL AFJ36608.1
OrganismMycobacterium sp. MOTT36Y [Complete proteome] EMBL AFJ36608.1
Taxonomic identifier1168287 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain164 – 371208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding192 – 24756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3261Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3381Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3381Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3401Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I2AH34 [UniParc].

Last modified July 11, 2012. Version 1.
Checksum: 4059E792AED186BB

FASTA38140,160
        10         20         30         40         50         60 
MNASDRSTPH PGSGGGERAR VAVVFGGRSN EHAISCVSAG SILRNLDPER FEVVAIGITP 

        70         80         90        100        110        120 
EGSWVLTDGD PAALAITDRR LPEVTAESGT ELALPADPRR GGQLVSLPPG AGEVLASVDV 

       130        140        150        160        170        180 
VFPVLHGPYG EDGTIQGLLE LAGVPYVGAG VLASAAGMDK EFTKKLFAAE GLPVGDYAVL 

       190        200        210        220        230        240 
RPSRARLRPE ECQRLGLPVF VKPARGGSSI GVSRVASWDQ LDAAVAAARR HDPKVIVEAA 

       250        260        270        280        290        300 
IVGRELECGV LEMPDGTVEA SALGEIRVAG VRGREDSFYD FATKYLDDAA ELDVPAKVDD 

       310        320        330        340        350        360 
EIADTVRQLA IRAFKAIDCQ GLARVDFFLT EDGPVLNEIN TMPGFTTISM YPRMWAASGV 

       370        380 
DYPTLLATMV ETALARGVGL R 

« Hide

References

[1]"Complete genome sequence of Mycobacterium intracellulare clinical strain MOTT-36Y, belonging to the INT5 genotype."
Kim B.J., Choi B.S., Choi I.Y., Lee J.H., Chun J., Hong S.H., Kook Y.H., Kim B.J.
J. Bacteriol. 194:4141-4142(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT36Y EMBL AFJ36608.1.
[2]Kim B.-J., Choi B.-S., Lim J.-S., Choi I.-Y., Kook Y.-H., Kim B.-J.
Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT36Y EMBL AFJ36608.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003491 Genomic DNA. Translation: AFJ36608.1.
RefSeqYP_006307335.1. NC_017904.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFJ36608; AFJ36608; W7S_18265.
GeneID12943421.
KEGGmmm:W7S_18265.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycMSP1168287:GLGR-3661-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI2AH34_9MYCO
AccessionPrimary (citable) accession number: I2AH34
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: April 16, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)