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I1ZKW9 (I1ZKW9_STRPA) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL AFJ25693.1
Synonyms:ddl HAMAP-Rule MF_00047
ORF Names:Spaf_0686 EMBL AFJ25693.1
OrganismStreptococcus parasanguinis FW213 EMBL AFJ25693.1
Taxonomic identifier1114965 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. SAAS SAAS005905 HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. SAAS SAAS005905 HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905 HAMAP-Rule MF_00047

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005905 HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity SAAS SAAS005905 HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. SAAS SAAS005905 HAMAP-Rule MF_00047

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain132 – 334203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding162 – 21756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2881Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3031Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I1ZKW9 [UniParc].

Last modified July 11, 2012. Version 1.
Checksum: 2E1CAED1CAEEF0D5

FASTA34838,587
        10         20         30         40         50         60 
MSKQDLILLY GGRSAEREVS VLSAESVMRA IDYQAFSVQT YFITQSGDFI QTQAFEEKPA 

        70         80         90        100        110        120 
DDEKLMTNET VDWSKKVAPS AIYKEGAVVF PVLHGPMGED GSIQGFLEVL KMPYVGCGIL 

       130        140        150        160        170        180 
ASSVAMDKIT TKRVLESAGI PQVPYVAVVE GDDLEEKIAA IEANLSYPVF TKPSNMGSSV 

       190        200        210        220        230        240 
GISKSENQTE LRTALELAFK YDSRVLVEQG VNAREIEVGL LGNYDVKSTL PGEVVKDVAF 

       250        260        270        280        290        300 
YDYDAKYIDN KITMAIPAQL DPEVVKTMRT NAEKAFRAIG GLGLARCDFF YTDKGEIFLN 

       310        320        330        340 
ELNTMPGFTQ WSMYPLLWDN MGLNYTDLIT KLVELGKEVF QKHEAHLL

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References

[1]"Complete Genome and Transcriptomes of Streptococcus parasanguinis FW213: Phylogenic Relations and Potential Virulence Mechanisms."
Geng J., Chiu C.H., Tang P., Chen Y., Shieh H.R., Hu S., Chen Y.Y.
PLoS ONE 7:E34769-E34769(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: FW213 EMBL AFJ25693.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003122 Genomic DNA. Translation: AFJ25693.1.
RefSeqYP_006309507.1. NC_017905.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFJ25693; AFJ25693; Spaf_0686.
GeneID12944366.
KEGGscf:Spaf_0686.

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI1ZKW9_STRPA
AccessionPrimary (citable) accession number: I1ZKW9
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: April 3, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info