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I1YX57

- I1YX57_PREI7

UniProt

I1YX57 - I1YX57_PREI7

Protein

Thymidine kinase

Gene

tdk

Organism
Prevotella intermedia (strain 17)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (11 Jul 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Proton acceptorUniRule annotation
    Metal bindingi151 – 1511ZincUniRule annotation
    Metal bindingi154 – 1541ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation
    Metal bindingi186 – 1861ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 298ATPUniRule annotation
    Nucleotide bindingi94 – 974ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciPINT246198:GLIH-1160-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:PIN17_A1240Imported
    OrganismiPrevotella intermedia (strain 17)Imported
    Taxonomic identifieri246198 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella
    ProteomesiUP000010099: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    I1YX57-1 [UniParc]FASTAAdd to Basket

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    MVAIDNLNGE RRRQGRIEVI CGSMFSGKTE ELIRRMKRAK FAKQKVEIFK    50
    PAIDMRYSEE DVVSHDQNAI RSTPINSSGN ILLLASDIEV VGIDEAQFLD 100
    EGLVDICNQL ANNGVRVIVA GLDMDFKGVP FGPIPSLCAV ADQVTKVHAI 150
    CVKCGALAYA SHRLVDNDHR VMLGEQMEYE PLCRECYQKA LSEEMQRKQS 200
    NP 202
    Length:202
    Mass (Da):22,541
    Last modified:July 11, 2012 - v1
    Checksum:i9E8B77167784D7FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003503 Genomic DNA. Translation: AFJ09696.1.
    RefSeqiYP_006299133.1. NC_017861.1.

    Genome annotation databases

    EnsemblBacteriaiAFJ09696; AFJ09696; PIN17_A1240.
    GeneIDi12848967.
    KEGGipit:PIN17_A1240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003503 Genomic DNA. Translation: AFJ09696.1 .
    RefSeqi YP_006299133.1. NC_017861.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFJ09696 ; AFJ09696 ; PIN17_A1240 .
    GeneIDi 12848967.
    KEGGi pit:PIN17_A1240.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci PINT246198:GLIH-1160-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Heidelberg J., Mongodin E., Moffat K., Khouri H., Brinkac L., Durkin A.S., Duncan M., Nelson K.E.
      Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17Imported.

    Entry informationi

    Entry nameiI1YX57_PREI7
    AccessioniPrimary (citable) accession number: I1YX57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2012
    Last sequence update: July 11, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3