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I1YX57

- I1YX57_PREI7

UniProt

I1YX57 - I1YX57_PREI7

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Protein
Thymidine kinase
Gene
tdk, PIN17_A1240
Organism
Prevotella intermedia (strain 17)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton acceptor By similarityUniRule annotation
Metal bindingi151 – 1511Zinc By similarityUniRule annotation
Metal bindingi154 – 1541Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation
Metal bindingi186 – 1861Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 298ATP By similarityUniRule annotation
Nucleotide bindingi94 – 974ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPINT246198:GLIH-1160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:PIN17_A1240Imported
OrganismiPrevotella intermedia (strain 17)Imported
Taxonomic identifieri246198 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella
ProteomesiUP000010099: Chromosome II

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

I1YX57-1 [UniParc]FASTAAdd to Basket

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MVAIDNLNGE RRRQGRIEVI CGSMFSGKTE ELIRRMKRAK FAKQKVEIFK    50
PAIDMRYSEE DVVSHDQNAI RSTPINSSGN ILLLASDIEV VGIDEAQFLD 100
EGLVDICNQL ANNGVRVIVA GLDMDFKGVP FGPIPSLCAV ADQVTKVHAI 150
CVKCGALAYA SHRLVDNDHR VMLGEQMEYE PLCRECYQKA LSEEMQRKQS 200
NP 202
Length:202
Mass (Da):22,541
Last modified:July 11, 2012 - v1
Checksum:i9E8B77167784D7FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003503 Genomic DNA. Translation: AFJ09696.1.
RefSeqiYP_006299133.1. NC_017861.1.

Genome annotation databases

EnsemblBacteriaiAFJ09696; AFJ09696; PIN17_A1240.
GeneIDi12848967.
KEGGipit:PIN17_A1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003503 Genomic DNA. Translation: AFJ09696.1 .
RefSeqi YP_006299133.1. NC_017861.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFJ09696 ; AFJ09696 ; PIN17_A1240 .
GeneIDi 12848967.
KEGGi pit:PIN17_A1240.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci PINT246198:GLIH-1160-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Heidelberg J., Mongodin E., Moffat K., Khouri H., Brinkac L., Durkin A.S., Duncan M., Nelson K.E.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17Imported.

Entry informationi

Entry nameiI1YX57_PREI7
AccessioniPrimary (citable) accession number: I1YX57
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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