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I1XYB6

- I1XYB6_ACIBA

UniProt

I1XYB6 - I1XYB6_ACIBA

Protein

Isocitrate dehydrogenase [NADP]

Gene

ABTJ_01030

Organism
Acinetobacter baumannii MDR-TJ
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 12 (01 Oct 2014)
      Sequence version 1 (11 Jul 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciABAU889738:GL7L-1021-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:ABTJ_01030Imported
    OrganismiAcinetobacter baumannii MDR-TJImported
    Taxonomic identifieri889738 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000009146: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I1XYB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYQKIVVPA DGDKITVKAD LSLNVPNHPI IPFIEGDGIG VDITPAMKKV    50
    VDAAILKAYG GKRSIEWMEV YCGEKANKIY GTYMPEETFE ALREFVVSIK 100
    GPLTTPVGGG IRSLNVALRQ ELDLYVCVRP VRWFQGVPSP VQHPELTDMV 150
    IFRENSEDIY AGIEWKADSE EAKKVIKFLQ EEMGVTKIRF PEGCGIGIKP 200
    VSKEGTQRLV RKAIQFAIDN DKPSVTLVHK GNIMKYTEGA FKEWGYELAL 250
    DRFGGELIDG GPWVKIKNPK NGKDIIIKDV IADAFLQQIL MRPADYSVIA 300
    TLNLNGDYIS DALAAEVGGI GIAPGANIGG AIAVYEATHG TAPKYAGQDK 350
    VNPGSIILSA EMMLRDMGWT EAADLIIKGI SGAIAAKTVT YDFERLMPGA 400
    TLLRCSEFGD AIIQHMED 418
    Length:418
    Mass (Da):45,623
    Last modified:July 11, 2012 - v1
    Checksum:iB4129B0A73ACB50F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003500 Genomic DNA. Translation: AFI94652.1.
    RefSeqiYP_006288947.1. NC_017847.1.

    Genome annotation databases

    EnsemblBacteriaiAFI94652; AFI94652; ABTJ_01030.
    GeneIDi12840278.
    KEGGiabr:ABTJ_01030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003500 Genomic DNA. Translation: AFI94652.1 .
    RefSeqi YP_006288947.1. NC_017847.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFI94652 ; AFI94652 ; ABTJ_01030 .
    GeneIDi 12840278.
    KEGGi abr:ABTJ_01030.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci ABAU889738:GL7L-1021-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MDR-TJImported.

    Entry informationi

    Entry nameiI1XYB6_ACIBA
    AccessioniPrimary (citable) accession number: I1XYB6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2012
    Last sequence update: July 11, 2012
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3