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I1W9N9

- I1W9N9_BIFAR

UniProt

I1W9N9 - I1W9N9_BIFAR

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Protein
Isocitrate dehydrogenase [NADP]
Gene
BANAN_03785
Organism
Bifidobacterium animalis subsp. animalis (strain ATCC 25527 / DSM 20104 / JCM 1190 / R101-8)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei211 – 2111Critical for catalysis By similarityUniRule annotation
Metal bindingi251 – 2511Magnesium or manganese By similarityUniRule annotation
Binding sitei259 – 2591NADP By similarityUniRule annotation
Metal bindingi274 – 2741Magnesium or manganese By similarityUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi309 – 3146NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBANI703613:GL91-772-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:BANAN_03785Imported
OrganismiBifidobacterium animalis subsp. animalis (strain ATCC 25527 / DSM 20104 / JCM 1190 / R101-8)Imported
Taxonomic identifieri703613 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000009141: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1W9N9-1 [UniParc]FASTAAdd to Basket

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MAKIKVEGKV VELDGDEMTR VIWKDIKDRL ILPYLDIDLD YYDLGIENRD    50
ATDDQVTIDA AEAIKREHVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR 100
NILGGTIFRE PIVIDNIPRL VPGWTKPIVV ARHAFGDQYK ATDFKVPTSG 150
TLTVTFTPND GSEPIEHVVF DYPGSGVAQV QYNLDESIRG FARACFNYGL 200
LRHYPVYLST KNTILKAYDG EFKDIFAEVF ETEYKQRYEQ EGLTYEHRLI 250
DDMVASSLKW HGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMTPDGQ 300
TVEAEAAHGT VTRHYRRWQK GEKTSTNPIA SIYAWTGGLK HRAKLDGTPQ 350
VANFAETLEQ TIISTVEGGQ MTKDLAILID PSHEWLDTEQ FMNALDENLQ 400
RNLAEQR 407
Length:407
Mass (Da):45,885
Last modified:July 11, 2012 - v1
Checksum:i518B7E387E8E21C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002567 Genomic DNA. Translation: AFI62971.1.
RefSeqiYP_006279934.1. NC_017834.1.

Genome annotation databases

EnsemblBacteriaiAFI62971; AFI62971; BANAN_03785.
GeneIDi12835229.
KEGGibni:BANAN_03785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002567 Genomic DNA. Translation: AFI62971.1 .
RefSeqi YP_006279934.1. NC_017834.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFI62971 ; AFI62971 ; BANAN_03785 .
GeneIDi 12835229.
KEGGi bni:BANAN_03785.

Phylogenomic databases

KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci BANI703613:GL91-772-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Short communication: the complete genome sequence of Bifidobacterium animalis subspecies animalis ATCC 25527(T) and comparative analysis of growth in milk with B. animalis subspecies lactis DSM 10140(T)."
    Loquasto J.R., Barrangou R., Dudley E.G., Roberts R.F.
    J. Dairy Sci. 94:5864-5870(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25527Imported.

Entry informationi

Entry nameiI1W9N9_BIFAR
AccessioniPrimary (citable) accession number: I1W9N9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: July 9, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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