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I1W9N9 (I1W9N9_BIFAR) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding309 – 3146NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2591NADP By similarity PIRSR PIRSR000108-4
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
I1W9N9 [UniParc].

Last modified July 11, 2012. Version 1.
Checksum: 518B7E387E8E21C0

FASTA40745,885
        10         20         30         40         50         60 
MAKIKVEGKV VELDGDEMTR VIWKDIKDRL ILPYLDIDLD YYDLGIENRD ATDDQVTIDA 

        70         80         90        100        110        120 
AEAIKREHVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR NILGGTIFRE PIVIDNIPRL 

       130        140        150        160        170        180 
VPGWTKPIVV ARHAFGDQYK ATDFKVPTSG TLTVTFTPND GSEPIEHVVF DYPGSGVAQV 

       190        200        210        220        230        240 
QYNLDESIRG FARACFNYGL LRHYPVYLST KNTILKAYDG EFKDIFAEVF ETEYKQRYEQ 

       250        260        270        280        290        300 
EGLTYEHRLI DDMVASSLKW HGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMTPDGQ 

       310        320        330        340        350        360 
TVEAEAAHGT VTRHYRRWQK GEKTSTNPIA SIYAWTGGLK HRAKLDGTPQ VANFAETLEQ 

       370        380        390        400 
TIISTVEGGQ MTKDLAILID PSHEWLDTEQ FMNALDENLQ RNLAEQR 

« Hide

References

[1]"Short communication: the complete genome sequence of Bifidobacterium animalis subspecies animalis ATCC 25527(T) and comparative analysis of growth in milk with B. animalis subspecies lactis DSM 10140(T)."
Loquasto J.R., Barrangou R., Dudley E.G., Roberts R.F.
J. Dairy Sci. 94:5864-5870(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25527 EMBL AFI62971.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002567 Genomic DNA. Translation: AFI62971.1.
RefSeqYP_006279934.1. NC_017834.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFI62971; AFI62971; BANAN_03785.
GeneID12835229.
KEGGbni:BANAN_03785.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.
OMAKNTIMKV.

Enzyme and pathway databases

BioCycBANI703613:GL91-772-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI1W9N9_BIFAR
AccessionPrimary (citable) accession number: I1W9N9
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: July 9, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)