Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

I1W9N9

- I1W9N9_BIFAR

UniProt

I1W9N9 - I1W9N9_BIFAR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate dehydrogenase [NADP]

Gene

BANAN_03785

Organism
Bifidobacterium animalis subsp. animalis (strain ATCC 25527 / DSM 20104 / JCM 1190 / R101-8)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei211 – 2111Critical for catalysisUniRule annotation
Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBANI703613:GL91-772-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:BANAN_03785Imported
OrganismiBifidobacterium animalis subsp. animalis (strain ATCC 25527 / DSM 20104 / JCM 1190 / R101-8)Imported
Taxonomic identifieri703613 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000009141: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1W9N9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVEGKV VELDGDEMTR VIWKDIKDRL ILPYLDIDLD YYDLGIENRD
60 70 80 90 100
ATDDQVTIDA AEAIKREHVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR
110 120 130 140 150
NILGGTIFRE PIVIDNIPRL VPGWTKPIVV ARHAFGDQYK ATDFKVPTSG
160 170 180 190 200
TLTVTFTPND GSEPIEHVVF DYPGSGVAQV QYNLDESIRG FARACFNYGL
210 220 230 240 250
LRHYPVYLST KNTILKAYDG EFKDIFAEVF ETEYKQRYEQ EGLTYEHRLI
260 270 280 290 300
DDMVASSLKW HGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMTPDGQ
310 320 330 340 350
TVEAEAAHGT VTRHYRRWQK GEKTSTNPIA SIYAWTGGLK HRAKLDGTPQ
360 370 380 390 400
VANFAETLEQ TIISTVEGGQ MTKDLAILID PSHEWLDTEQ FMNALDENLQ

RNLAEQR
Length:407
Mass (Da):45,885
Last modified:July 11, 2012 - v1
Checksum:i518B7E387E8E21C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002567 Genomic DNA. Translation: AFI62971.1.
RefSeqiWP_014697617.1. NC_017834.1.
YP_006279934.1. NC_017834.1.

Genome annotation databases

EnsemblBacteriaiAFI62971; AFI62971; BANAN_03785.
GeneIDi12835229.
KEGGibni:BANAN_03785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002567 Genomic DNA. Translation: AFI62971.1 .
RefSeqi WP_014697617.1. NC_017834.1.
YP_006279934.1. NC_017834.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFI62971 ; AFI62971 ; BANAN_03785 .
GeneIDi 12835229.
KEGGi bni:BANAN_03785.

Phylogenomic databases

KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci BANI703613:GL91-772-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Short communication: the complete genome sequence of Bifidobacterium animalis subspecies animalis ATCC 25527(T) and comparative analysis of growth in milk with B. animalis subspecies lactis DSM 10140(T)."
    Loquasto J.R., Barrangou R., Dudley E.G., Roberts R.F.
    J. Dairy Sci. 94:5864-5870(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25527 / DSM 20104 / JCM 1190 / R101-8Imported.

Entry informationi

Entry nameiI1W9N9_BIFAR
AccessioniPrimary (citable) accession number: I1W9N9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 26, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3