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Protein
Submitted name:

UBE2L3/KRAS fusion protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTP binding Source: UniProtKB-KW
  4. ligase activity Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. cytokine-mediated signaling pathway Source: Ensembl
  3. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  4. negative regulation of cell differentiation Source: Ensembl
  5. negative regulation of neuron apoptotic process Source: Ensembl
  6. positive regulation of cell proliferation Source: Ensembl
  7. positive regulation of MAP kinase activity Source: Ensembl
  8. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  9. positive regulation of nitric-oxide synthase activity Source: Ensembl
  10. positive regulation of Rac protein signal transduction Source: Ensembl
  11. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  12. regulation of synaptic transmission, GABAergic Source: Ensembl
  13. response to glucocorticoid Source: Ensembl
  14. response to mineralocorticoid Source: Ensembl
  15. small GTPase mediated signal transduction Source: InterPro
  16. social behavior Source: Ensembl
  17. striated muscle cell differentiation Source: Ensembl
  18. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotation

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
UBE2L3/KRAS fusion proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. membrane raft Source: Ensembl
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiI1SRC5.
ExpressionAtlasiI1SRC5. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliI1SRC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation

Phylogenomic databases

KOiK07827.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54495. SSF54495. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1SRC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA
60 70 80 90 100
FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK
110 120 130 140 150
TDQGLLKMTE YKLVVVGAGG VGKSALTIQL IQNHFVDEYD PTIEDSYRKQ
160 170 180 190 200
VVIDGETCLL DILDTAGQEE YSAMRDQYMR TGEGFLCVFA INNTKSFEDI
210 220 230 240 250
HHYREQIKRV KDSEDVPMVL VGNKCDLPSR TVDTKQAQDL ARSYGIPFIE
260 270 280 290
TSAKTRQRVE DAFYTLVREI RQYRLKKISK EEKTPGCVKI KKCIIM
Length:296
Mass (Da):33,983
Last modified:July 11, 2012 - v1
Checksum:i564873E7568723AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF343812 mRNA. Translation: AEA35014.1.
RefSeqiNP_203524.1. NM_033360.3.
UniGeneiHs.505033.

Genome annotation databases

GeneIDi3845.
KEGGihsa:3845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF343812 mRNA. Translation: AEA35014.1.
RefSeqiNP_203524.1. NM_033360.3.
UniGeneiHs.505033.

3D structure databases

ProteinModelPortaliI1SRC5.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiI1SRC5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3845.
KEGGihsa:3845.

Organism-specific databases

CTDi3845.

Phylogenomic databases

KOiK07827.

Miscellaneous databases

GenomeRNAii3845.
NextBioi35531955.

Gene expression databases

BgeeiI1SRC5.
ExpressionAtlasiI1SRC5. baseline and differential.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54495. SSF54495. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Prostate cancerImported.

Entry informationi

Entry nameiI1SRC5_HUMAN
AccessioniPrimary (citable) accession number: I1SRC5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: April 1, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.