SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

I1SRC5

- I1SRC5_HUMAN

UniProt

I1SRC5 - I1SRC5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

UBE2L3/KRAS fusion protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. GDP binding Source: Ensembl
  3. GMP binding Source: Ensembl
  4. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. cytokine-mediated signaling pathway Source: Ensembl
  3. GTP catabolic process Source: InterPro
  4. negative regulation of neuron apoptotic process Source: Ensembl
  5. positive regulation of cell proliferation Source: Ensembl
  6. positive regulation of MAP kinase activity Source: Ensembl
  7. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  8. positive regulation of nitric-oxide synthase activity Source: Ensembl
  9. positive regulation of Rac protein signal transduction Source: Ensembl
  10. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  11. regulation of synaptic transmission, GABAergic Source: Ensembl
  12. response to glucocorticoid Source: Ensembl
  13. response to mineralocorticoid Source: Ensembl
  14. small GTPase mediated signal transduction Source: InterPro
  15. social behavior Source: Ensembl
  16. striated muscle cell differentiation Source: Ensembl
  17. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotations

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotations

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
UBE2L3/KRAS fusion proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. membrane raft Source: Ensembl
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiI1SRC5.
BgeeiI1SRC5.

Structurei

3D structure databases

ProteinModelPortaliI1SRC5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK07827.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54495. SSF54495. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1SRC5-1 [UniParc]FASTAAdd to Basket

« Hide

MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA    50
FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK 100
TDQGLLKMTE YKLVVVGAGG VGKSALTIQL IQNHFVDEYD PTIEDSYRKQ 150
VVIDGETCLL DILDTAGQEE YSAMRDQYMR TGEGFLCVFA INNTKSFEDI 200
HHYREQIKRV KDSEDVPMVL VGNKCDLPSR TVDTKQAQDL ARSYGIPFIE 250
TSAKTRQRVE DAFYTLVREI RQYRLKKISK EEKTPGCVKI KKCIIM 296
Length:296
Mass (Da):33,983
Last modified:July 11, 2012 - v1
Checksum:i564873E7568723AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF343812 mRNA. Translation: AEA35014.1.
RefSeqiNP_203524.1. NM_033360.3.
UniGeneiHs.505033.

Genome annotation databases

GeneIDi3845.
KEGGihsa:3845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF343812 mRNA. Translation: AEA35014.1 .
RefSeqi NP_203524.1. NM_033360.3.
UniGenei Hs.505033.

3D structure databases

ProteinModelPortali I1SRC5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3845.
KEGGi hsa:3845.

Organism-specific databases

CTDi 3845.

Phylogenomic databases

KOi K07827.

Miscellaneous databases

NextBioi 35531955.

Gene expression databases

ArrayExpressi I1SRC5.
Bgeei I1SRC5.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF54495. SSF54495. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Prostate cancerImported.

Entry informationi

Entry nameiI1SRC5_HUMAN
AccessioniPrimary (citable) accession number: I1SRC5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi