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I1SRC5

- I1SRC5_HUMAN

UniProt

I1SRC5 - I1SRC5_HUMAN

Protein
Submitted name:

UBE2L3/KRAS fusion protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (11 Jul 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. GDP binding Source: Ensembl
    3. GMP binding Source: Ensembl
    4. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. cytokine-mediated signaling pathway Source: Ensembl
    3. GTP catabolic process Source: InterPro
    4. negative regulation of neuron apoptotic process Source: Ensembl
    5. positive regulation of cell proliferation Source: Ensembl
    6. positive regulation of MAP kinase activity Source: Ensembl
    7. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    8. positive regulation of nitric-oxide synthase activity Source: Ensembl
    9. positive regulation of Rac protein signal transduction Source: Ensembl
    10. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    11. regulation of synaptic transmission, GABAergic Source: Ensembl
    12. response to glucocorticoid Source: Ensembl
    13. response to mineralocorticoid Source: Ensembl
    14. small GTPase mediated signal transduction Source: InterPro
    15. social behavior Source: Ensembl
    16. striated muscle cell differentiation Source: Ensembl
    17. visual learning Source: Ensembl

    Keywords - Molecular functioni

    LigaseSAAS annotation

    Keywords - Biological processi

    Ubl conjugation pathwaySAAS annotation

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    UBE2L3/KRAS fusion proteinImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. membrane raft Source: Ensembl
    2. mitochondrion Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiI1SRC5.
    BgeeiI1SRC5.

    Structurei

    3D structure databases

    ProteinModelPortaliI1SRC5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation

    Phylogenomic databases

    KOiK07827.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54495. SSF54495. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I1SRC5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA    50
    FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK 100
    TDQGLLKMTE YKLVVVGAGG VGKSALTIQL IQNHFVDEYD PTIEDSYRKQ 150
    VVIDGETCLL DILDTAGQEE YSAMRDQYMR TGEGFLCVFA INNTKSFEDI 200
    HHYREQIKRV KDSEDVPMVL VGNKCDLPSR TVDTKQAQDL ARSYGIPFIE 250
    TSAKTRQRVE DAFYTLVREI RQYRLKKISK EEKTPGCVKI KKCIIM 296
    Length:296
    Mass (Da):33,983
    Last modified:July 11, 2012 - v1
    Checksum:i564873E7568723AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF343812 mRNA. Translation: AEA35014.1.
    RefSeqiNP_203524.1. NM_033360.3.
    UniGeneiHs.505033.

    Genome annotation databases

    GeneIDi3845.
    KEGGihsa:3845.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF343812 mRNA. Translation: AEA35014.1 .
    RefSeqi NP_203524.1. NM_033360.3.
    UniGenei Hs.505033.

    3D structure databases

    ProteinModelPortali I1SRC5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3845.
    KEGGi hsa:3845.

    Organism-specific databases

    CTDi 3845.

    Phylogenomic databases

    KOi K07827.

    Miscellaneous databases

    GenomeRNAii 3845.
    NextBioi 35531955.

    Gene expression databases

    ArrayExpressi I1SRC5.
    Bgeei I1SRC5.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54495. SSF54495. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Prostate cancerImported.

    Entry informationi

    Entry nameiI1SRC5_HUMAN
    AccessioniPrimary (citable) accession number: I1SRC5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2012
    Last sequence update: July 11, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.