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I1RLM3

- I1RLM3_GIBZE

UniProt

I1RLM3 - I1RLM3_GIBZE

Protein

Kynureninase

Gene

FG04829.1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei161 – 1611Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei162 – 1621Pyridoxal phosphateUniRule annotation
    Binding sitei273 – 2731Pyridoxal phosphateUniRule annotation
    Binding sitei276 – 2761Pyridoxal phosphateUniRule annotation
    Binding sitei298 – 2981Pyridoxal phosphateUniRule annotation
    Binding sitei338 – 3381Pyridoxal phosphateUniRule annotation
    Binding sitei366 – 3661Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    Biosynthesis of nicotinic acid protein 5UniRule annotation
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:FG04829.1Imported
    Synonyms:BNA5UniRule annotation
    ORF Names:FGSG_04829Imported
    OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)Imported
    Taxonomic identifieri229533 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
    ProteomesiUP000009057: Chromosome 3

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei299 – 2991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni189 – 1924Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.
    OrthoDBiEOG7V1G0J.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 2 hits.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    I1RLM3-1 [UniParc]FASTAAdd to Basket

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    MELSSFVERL RSSAPPKFPS DANSLDFARN LDSQDKLSHL RDEFILPTKK    50
    SLKKKALDGS IPNGHAQNGS VNGTNGHTNG QDDDQQCIYF VGNSLGAQPK 100
    AVREHLNAQL ETWASVGVNG HFSAMGNSPL PAWQDLAEDC AIRSADIVGA 150
    SPHEIVIMNT LTANLHLLMA SFYKPNEKRH KVILEWKPFP SDHYAIESQV 200
    VWHGLDPEKS MVKIEPNEDH IITTDLILST IDQHADDTAL LLLPGIQYYS 250
    GQLFDIPRIT AYAQAKGIVV GWDLAHAAGN VELKLHDWNV DFACWCTYKY 300
    INAGPGSIAG AYVHERHGKV EMNSETGKAS YRPRLMGWYG GDKSVRFNMD 350
    NNFIPTAGAG GFQLSNPSAI DLASLSGALS VFNKTTMHDL RSKALVLTAY 400
    SEYLLDQILS ESGDSELFRI ITPRDPLQRG TQLSVLLKDG LLDNVSAALE 450
    ENAVICDKRK PGVIRVAPVP LYSRFEDVWR FMQILRGALK N 491
    Length:491
    Mass (Da):54,235
    Last modified:June 13, 2012 - v1
    Checksum:i858E6BA7996A792A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231665 Genomic DNA. Translation: ESU10704.1.
    RefSeqiXP_385005.1. XM_385005.1.

    Genome annotation databases

    EnsemblFungiiFGSG_04829T0; FGSG_04829P0; FGSG_04829.
    GeneIDi2786459.
    KEGGifgr:FG04829.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231665 Genomic DNA. Translation: ESU10704.1 .
    RefSeqi XP_385005.1. XM_385005.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii FGSG_04829T0 ; FGSG_04829P0 ; FGSG_04829 .
    GeneIDi 2786459.
    KEGGi fgr:FG04829.1.

    Phylogenomic databases

    KOi K01556.
    OrthoDBi EOG7V1G0J.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 2 hits.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PH-1Imported.
    3. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
      Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
      , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
      Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084Imported.
    4. EnsemblFungi
      Submitted (OCT-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084Imported.

    Entry informationi

    Entry nameiI1RLM3_GIBZE
    AccessioniPrimary (citable) accession number: I1RLM3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3