Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kynureninase

Gene

FG04829.1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (FG04829.1), Kynureninase (FG04131.1)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (FG01395.1)
  2. Kynureninase (FG04829.1), Kynureninase (FG04131.1)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (FG07058.1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei161Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei162Pyridoxal phosphateUniRule annotation1
Binding sitei273Pyridoxal phosphateUniRule annotation1
Binding sitei276Pyridoxal phosphateUniRule annotation1
Binding sitei298Pyridoxal phosphateUniRule annotation1
Binding sitei338Pyridoxal phosphateUniRule annotation1
Binding sitei366Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:FG04829.1Imported
Synonyms:BNA5UniRule annotation
ORF Names:FGRAMPH1_01T16409Imported
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)Imported
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
Proteomesi
  • UP000070720 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiFungiDB:FGRAMPH1_01G16409.

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei299N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi229533.XP_385005.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 315Aminotran_5InterPro annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 192Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3846. Eukaryota.
COG3844. LUCA.
KOiK01556.
OrthoDBiEOG092C20ON.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01970. Kynureninase. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

I1RLM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSSFVERL RSSAPPKFPS DANSLDFARN LDSQDKLSHL RDEFILPTKK
60 70 80 90 100
SLKKKALDGS IPNGHAQNGS VNGTNGHTNG QDDDQQCIYF VGNSLGAQPK
110 120 130 140 150
AVREHLNAQL ETWASVGVNG HFSAMGNSPL PAWQDLAEDC AIRSADIVGA
160 170 180 190 200
SPHEIVIMNT LTANLHLLMA SFYKPNEKRH KVILEWKPFP SDHYAIESQV
210 220 230 240 250
VWHGLDPEKS MVKIEPNEDH IITTDLILST IDQHADDTAL LLLPGIQYYS
260 270 280 290 300
GQLFDIPRIT AYAQAKGIVV GWDLAHAAGN VELKLHDWNV DFACWCTYKY
310 320 330 340 350
INAGPGSIAG AYVHERHGKV EMNSETGKAS YRPRLMGWYG GDKSVRFNMD
360 370 380 390 400
NNFIPTAGAG GFQLSNPSAI DLASLSGALS VFNKTTMHDL RSKALVLTAY
410 420 430 440 450
SEYLLDQILS ESGDSELFRI ITPRDPLQRG TQLSVLLKDG LLDNVSAALE
460 470 480 490
ENAVICDKRK PGVIRVAPVP LYSRFEDVWR FMQILRGALK N
Length:491
Mass (Da):54,235
Last modified:June 13, 2012 - v1
Checksum:i858E6BA7996A792A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG970334 Genomic DNA. Translation: CEF86275.1.
RefSeqiXP_011323280.1. XM_011324978.1.

Genome annotation databases

EnsemblFungiiCEF86275; CEF86275; FGRRES_04829.
GeneIDi23552041.
KEGGifgr:FGSG_04829.

Similar proteinsi

Entry informationi

Entry nameiI1RLM3_GIBZE
AccessioniPrimary (citable) accession number: I1RLM3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: September 27, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported