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I1MJH1

- I1MJH1_SOYBN

UniProt

I1MJH1 - I1MJH1_SOYBN

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Protein
Isocitrate dehydrogenase [NADP]
Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Substrate By similarityUniRule annotation
Binding sitei84 – 841NADP By similarityUniRule annotation
Binding sitei111 – 1111Substrate By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Sitei141 – 1411Critical for catalysis By similarityUniRule annotation
Sitei214 – 2141Critical for catalysis By similarityUniRule annotation
Metal bindingi254 – 2541Magnesium or manganese By similarityUniRule annotation
Binding sitei262 – 2621NADP By similarityUniRule annotation
Metal bindingi277 – 2771Magnesium or manganese By similarityUniRule annotation
Binding sitei330 – 3301NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 793NADP By similarityUniRule annotation
Nucleotide bindingi312 – 3176NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
OrganismiGlycine max (Soybean) (Glycine hispida)Imported
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiI1MJH1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 1027Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiEANWRSK.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1MJH1-1 [UniParc]FASTAAdd to Basket

« Hide

MGFQKIRVGN PIVEMDGDEM TRVIWKLIKD KLIFPYLELD IKYFDLGLPH    50
RDATNDRVTI ESAEATLKYN VAIKCATITP DEARIKEFNL KQMWRSPNGT 100
IRNILNGTVF REPIICKNIP RLVSGWTKPI CIGRHAFGDQ YRATDTVIKG 150
PGKLKLVFAP SGNEGIKELE VYNFTGDGGI ALSMYNTDES IRAFAEASMN 200
FAYQKKWPLY LSTKNTILKK YDGRFKDIFQ EVFDTQWSHK FKAAGIWYEH 250
RLIDDMVAYA LKSDGGYVWA CKNYDGDVQS DFLAQGFGSL GLMTSVLVCP 300
DGKTIEAEAA HGTVTRHYRV HQKGGETSTN SIASIFAWSR GLAHRAKLDG 350
NARLLDFTEK LEAACIGTVE LGKMTKDLAL LVHGPKVSRY QYLNTEEFID 400
AVAKELQTRL SSQSKL 416
Length:416
Mass (Da):46,854
Last modified:June 13, 2012 - v1
Checksum:i6D2B122670FCED54
GO

Sequence databases

RefSeqiXP_003546847.1. XM_003546799.2.

Genome annotation databases

EnsemblPlantsiGLYMA15G42100.1; GLYMA15G42100.1; GLYMA15G42100.
GeneIDi100816688.
KEGGigmx:100816688.

Cross-referencesi

Sequence databases

RefSeqi XP_003546847.1. XM_003546799.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi I1MJH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi GLYMA15G42100.1 ; GLYMA15G42100.1 ; GLYMA15G42100 .
GeneIDi 100816688.
KEGGi gmx:100816688.

Phylogenomic databases

KOi K00031.
OMAi EANWRSK.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Williams 82Imported.
  2. EnsemblPlants
    Submitted (MAY-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Williams 82Imported.

Entry informationi

Entry nameiI1MJH1_SOYBN
AccessioniPrimary (citable) accession number: I1MJH1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: July 9, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi