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Protein

Isocitrate dehydrogenase [NADP]

Gene

100816688

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79SubstrateUniRule annotation1
Binding sitei84NADPUniRule annotation1
Binding sitei111SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Sitei141Critical for catalysisUniRule annotation1
Sitei214Critical for catalysisUniRule annotation1
Metal bindingi254Magnesium or manganeseUniRule annotation1
Binding sitei262NADPUniRule annotation1
Metal bindingi277Magnesium or manganeseUniRule annotation1
Binding sitei330NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 79NADPUniRule annotation3
Nucleotide bindingi312 – 317NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:100816688Imported
ORF Names:GLYMA_15G266700Imported
OrganismiGlycine max (Soybean) (Glycine hispida)Imported
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Chromosome 15

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA15G42100.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 402Iso_dhInterPro annotationAdd BLAST392

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 102Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031
OMAiRERWKIT
OrthoDBiEOG09370DQY

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

I1MJH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFQKIRVGN PIVEMDGDEM TRVIWKLIKD KLIFPYLELD IKYFDLGLPH
60 70 80 90 100
RDATNDRVTI ESAEATLKYN VAIKCATITP DEARIKEFNL KQMWRSPNGT
110 120 130 140 150
IRNILNGTVF REPIICKNIP RLVSGWTKPI CIGRHAFGDQ YRATDTVIKG
160 170 180 190 200
PGKLKLVFAP SGNEGIKELE VYNFTGDGGI ALSMYNTDES IRAFAEASMN
210 220 230 240 250
FAYQKKWPLY LSTKNTILKK YDGRFKDIFQ EVFDTQWSHK FKAAGIWYEH
260 270 280 290 300
RLIDDMVAYA LKSDGGYVWA CKNYDGDVQS DFLAQGFGSL GLMTSVLVCP
310 320 330 340 350
DGKTIEAEAA HGTVTRHYRV HQKGGETSTN SIASIFAWSR GLAHRAKLDG
360 370 380 390 400
NARLLDFTEK LEAACIGTVE LGKMTKDLAL LVHGPKVSRY QYLNTEEFID
410
AVAKELQTRL SSQSKL
Length:416
Mass (Da):46,854
Last modified:June 13, 2012 - v1
Checksum:i6D2B122670FCED54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACUP02009792 Genomic DNA No translation available.
CM000848 Genomic DNA Translation: KRH13828.1
RefSeqiXP_003546847.1, XM_003546799.3

Genome annotation databases

EnsemblPlantsiKRH13828; KRH13828; GLYMA_15G266700
GeneIDi100816688
GrameneiKRH13828; KRH13828; GLYMA_15G266700
KEGGigmx:100816688

Similar proteinsi

Entry informationi

Entry nameiI1MJH1_SOYBN
AccessioniPrimary (citable) accession number: I1MJH1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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