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I1MJH1

- I1MJH1_SOYBN

UniProt

I1MJH1 - I1MJH1_SOYBN

Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791SubstrateUniRule annotation
    Binding sitei84 – 841NADPUniRule annotation
    Binding sitei111 – 1111SubstrateUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Sitei141 – 1411Critical for catalysisUniRule annotation
    Sitei214 – 2141Critical for catalysisUniRule annotation
    Metal bindingi254 – 2541Magnesium or manganese
    Binding sitei262 – 2621NADPUniRule annotation
    Metal bindingi277 – 2771Magnesium or manganese
    Binding sitei330 – 3301NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi77 – 793NADPUniRule annotation
    Nucleotide bindingi312 – 3176NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    OrganismiGlycine max (Soybean) (Glycine hispida)Imported
    Taxonomic identifieri3847 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
    ProteomesiUP000008827: Chromosome 15

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: EnsemblPlants/Gramene

    PTM / Processingi

    Proteomic databases

    PRIDEiI1MJH1.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni96 – 1027Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiEANWRSK.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I1MJH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFQKIRVGN PIVEMDGDEM TRVIWKLIKD KLIFPYLELD IKYFDLGLPH    50
    RDATNDRVTI ESAEATLKYN VAIKCATITP DEARIKEFNL KQMWRSPNGT 100
    IRNILNGTVF REPIICKNIP RLVSGWTKPI CIGRHAFGDQ YRATDTVIKG 150
    PGKLKLVFAP SGNEGIKELE VYNFTGDGGI ALSMYNTDES IRAFAEASMN 200
    FAYQKKWPLY LSTKNTILKK YDGRFKDIFQ EVFDTQWSHK FKAAGIWYEH 250
    RLIDDMVAYA LKSDGGYVWA CKNYDGDVQS DFLAQGFGSL GLMTSVLVCP 300
    DGKTIEAEAA HGTVTRHYRV HQKGGETSTN SIASIFAWSR GLAHRAKLDG 350
    NARLLDFTEK LEAACIGTVE LGKMTKDLAL LVHGPKVSRY QYLNTEEFID 400
    AVAKELQTRL SSQSKL 416
    Length:416
    Mass (Da):46,854
    Last modified:June 13, 2012 - v1
    Checksum:i6D2B122670FCED54
    GO

    Sequence databases

    RefSeqiXP_003546847.1. XM_003546799.2.

    Genome annotation databases

    EnsemblPlantsiGLYMA15G42100.1; GLYMA15G42100.1; GLYMA15G42100.
    GeneIDi100816688.
    KEGGigmx:100816688.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_003546847.1. XM_003546799.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi I1MJH1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi GLYMA15G42100.1 ; GLYMA15G42100.1 ; GLYMA15G42100 .
    GeneIDi 100816688.
    KEGGi gmx:100816688.

    Phylogenomic databases

    KOi K00031.
    OMAi EANWRSK.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Williams 82Imported.
    2. EnsemblPlants
      Submitted (MAY-2013) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Williams 82Imported.

    Entry informationi

    Entry nameiI1MJH1_SOYBN
    AccessioniPrimary (citable) accession number: I1MJH1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3