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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791SubstrateUniRule annotation
Binding sitei84 – 841NADPUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Sitei141 – 1411Critical for catalysisUniRule annotation
Sitei214 – 2141Critical for catalysisUniRule annotation
Metal bindingi254 – 2541Magnesium or manganeseUniRule annotation
Binding sitei262 – 2621NADPUniRule annotation
Metal bindingi277 – 2771Magnesium or manganeseUniRule annotation
Binding sitei330 – 3301NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 793NADPUniRule annotation
Nucleotide bindingi312 – 3176NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
OrganismiGlycine max (Soybean) (Glycine hispida)Imported
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827 Componenti: Chromosome 15

PTM / Processingi

Proteomic databases

PRIDEiI1MJH1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 1027Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiI1MJH1.
KOiK00031.
OMAiQKEWEVY.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1MJH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFQKIRVGN PIVEMDGDEM TRVIWKLIKD KLIFPYLELD IKYFDLGLPH
60 70 80 90 100
RDATNDRVTI ESAEATLKYN VAIKCATITP DEARIKEFNL KQMWRSPNGT
110 120 130 140 150
IRNILNGTVF REPIICKNIP RLVSGWTKPI CIGRHAFGDQ YRATDTVIKG
160 170 180 190 200
PGKLKLVFAP SGNEGIKELE VYNFTGDGGI ALSMYNTDES IRAFAEASMN
210 220 230 240 250
FAYQKKWPLY LSTKNTILKK YDGRFKDIFQ EVFDTQWSHK FKAAGIWYEH
260 270 280 290 300
RLIDDMVAYA LKSDGGYVWA CKNYDGDVQS DFLAQGFGSL GLMTSVLVCP
310 320 330 340 350
DGKTIEAEAA HGTVTRHYRV HQKGGETSTN SIASIFAWSR GLAHRAKLDG
360 370 380 390 400
NARLLDFTEK LEAACIGTVE LGKMTKDLAL LVHGPKVSRY QYLNTEEFID
410
AVAKELQTRL SSQSKL
Length:416
Mass (Da):46,854
Last modified:June 12, 2012 - v1
Checksum:i6D2B122670FCED54
GO

Sequence databases

RefSeqiXP_003546847.1. XM_003546799.2.

Genome annotation databases

EnsemblPlantsiGLYMA15G42100.1; GLYMA15G42100.1; GLYMA15G42100.
GeneIDi100816688.
KEGGigmx:100816688.

Cross-referencesi

Sequence databases

RefSeqiXP_003546847.1. XM_003546799.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiI1MJH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGLYMA15G42100.1; GLYMA15G42100.1; GLYMA15G42100.
GeneIDi100816688.
KEGGigmx:100816688.

Phylogenomic databases

InParanoidiI1MJH1.
KOiK00031.
OMAiQKEWEVY.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Williams 82Imported.
  2. EnsemblPlants
    Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: IDENTIFICATION.
    Strain: Williams 82Imported.

Entry informationi

Entry nameiI1MJH1_SOYBN
AccessioniPrimary (citable) accession number: I1MJH1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2012
Last sequence update: June 12, 2012
Last modified: March 31, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.