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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

LOC100839523

Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:LOC100839523Imported
OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
Taxonomic identifieri15368 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeBrachypodieaeBrachypodium
Proteomesi
  • UP000008810 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

ExpressionAtlasiI1I1P6 baseline

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 101Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini146 – 183Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiKOG0557 Eukaryota
COG0508 LUCA

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

I1I1P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARANPVTLL PASLAGHYKV GLPPHMVIGM PALSPTMNQG NLAKWRKQEG
60 70 80 90 100
DKIEVGDVIC EIETDKATLE FESLEEGYLA KILVPEGSKD VQVGEPIFVT
110 120 130 140 150
VEESEDIKNI PADTSFGGEQ KEEQSSGSAA QSVQVDAAET SSVTSRISPA
160 170 180 190 200
AKMLIKEHGL DASLLKASGP RGTLLKGDVL AALKSGTASS AKEQTAPVAP
210 220 230 240 250
SPKPTRDTQA QSPITSQKSD TFEDITNTQI RKVIAKRLLE SKQTTPHLYL
260 270 280 290 300
SKDVILDPLL AFRNELKEQH GVKVSVNDIV IKAVALALRN VPEANAYWDT
310 320 330 340 350
AKQEAQKCDS VDISIAVATE KGLMTPIIRN ADQKTISAIS SEVKQLAKKA
360 370 380 390 400
RAGKLAPNEF QGGSFSISNL GMYPVDHFCA IINPPQAGIL AVGRGNKVVE
410 420 430 440 450
PVMDSDGTEK AAVLTKMSLT LSADHRIFDG QVGGKFFTEL ASNFSDIRRL

LL
Length:452
Mass (Da):48,418
Last modified:June 13, 2012 - v1
Checksum:iA123297671E4EBA4
GO

Genome annotation databases

EnsemblPlantsiBRADI3G17280.2; BRADI3G17280.2; BRADI3G17280
GrameneiBRADI3G17280.2; BRADI3G17280.2; BRADI3G17280

Similar proteinsi

Entry informationi

Entry nameiI1I1P6_BRADI
AccessioniPrimary (citable) accession number: I1I1P6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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