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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

BRADI3G00857

Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:BRADI3G00857Imported
OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
Taxonomic identifieri15368 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeBrachypodieaeBrachypodium
ProteomesiUP000008810 Componenti: Chromosome 3

Subcellular locationi

  1. Mitochondrion matrix UniRule annotation

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

InParanoidiI1HW51.
KOiK00627.
OMAiCIPTTIT.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1HW51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAHLLRHS RKLRSLRNVV DCERAGLARF FSTGSCSFAV KENGVEKRIG
60 70 80 90 100
GSTFSQCDQP GKDLQTFKVS LGGVIRSSTC RRTPSSRISS AVTGINGSLS
110 120 130 140 150
RVQVLSSRSF SSSADLPPHQ EIGMPSLSPT MTEGNIAKWV KKEGDKVSPG
160 170 180 190 200
EVLCEVETDK ATVEMECMEE GYLAKIVQGD GAKEIKVGEI ICVTVEEEGD
210 220 230 240 250
IEKFKDYKPS TSSDAPVAPA ESKPKSEPAE PKVEEKEPAK APEPKALKTA
260 270 280 290 300
EPQRSGDRIF SSPLARKLAE DTNVPLSSVK GTGPDGRILK ADIEDYLASV
310 320 330 340 350
AKGGKSESFA ASGLDYTDIP NAQIRKVTAN RLLTSKQTIP HYYLTVDTCV
360 370 380 390 400
DKLIKLRGEL NPLQDASGGK KISINDLVIK AAALALRKVP QCNSSWMNDF
410 420 430 440 450
IRQYNNVNIN VAVQTEHGLF VPVIKDADKK GLGTIAEEVK QLAQRARDNS
460 470 480 490 500
LKPADYEGGT FTVSNLGGPF GIKQFCAIIN PPQSAILAIG SAEKRVIPGG
510 520 530 540
ADGQYEFGSF MSVTMSCDHR VIDGAIGAEF LKAFKGYVEN PTTMLL
Length:546
Mass (Da):58,777
Last modified:June 13, 2012 - v1
Checksum:iEC5FD7735FCCC5F4
GO

Sequence databases

RefSeqiXP_003570870.1. XM_003570822.2.

Genome annotation databases

EnsemblPlantsiBRADI3G00857.2; BRADI3G00857.2; BRADI3G00857.
GeneIDi100830020.
KEGGibdi:100830020.

Cross-referencesi

Sequence databases

RefSeqiXP_003570870.1. XM_003570822.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiBRADI3G00857.2; BRADI3G00857.2; BRADI3G00857.
GeneIDi100830020.
KEGGibdi:100830020.

Phylogenomic databases

InParanoidiI1HW51.
KOiK00627.
OMAiCIPTTIT.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequencing and analysis of the model grass Brachypodium distachyon."
    International Brachypodium Initiative
    Nature 463:763-768(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Bd21Imported.
  2. EnsemblPlants
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: cv. Bd21Imported.

Entry informationi

Entry nameiI1HW51_BRADI
AccessioniPrimary (citable) accession number: I1HW51
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: April 29, 2015
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.