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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

LOC100830020

Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:LOC100830020Imported
ORF Names:BRADI_3g00857v3Imported
OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
Taxonomic identifieri15368 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeBrachypodieaeBrachypodium
Proteomesi
  • UP000008810 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi15368.BRADI3G00857.2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 195Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini260 – 297Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiKOG0557. Eukaryota.
COG0508. LUCA.
InParanoidiI1HW51.
KOiK00627.
OMAiLEMPKWG.
OrthoDBiEOG093607WT.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom_sf.
IPR036625. E3-bd_dom_sf.
IPR006257. LAT1.
IPR004167. PSBD.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
PS51826. PSBD. 1 hit.

Sequencei

Sequence statusi: Complete.

I1HW51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAHLLRHS RKLRSLRNVV DCERAGLARF FSTGSCSFAV KENGVEKRIG
60 70 80 90 100
GSTFSQCDQP GKDLQTFKVS LGGVIRSSTC RRTPSSRISS AVTGINGSLS
110 120 130 140 150
RVQVLSSRSF SSSADLPPHQ EIGMPSLSPT MTEGNIAKWV KKEGDKVSPG
160 170 180 190 200
EVLCEVETDK ATVEMECMEE GYLAKIVQGD GAKEIKVGEI ICVTVEEEGD
210 220 230 240 250
IEKFKDYKPS TSSDAPVAPA ESKPKSEPAE PKVEEKEPAK APEPKALKTA
260 270 280 290 300
EPQRSGDRIF SSPLARKLAE DTNVPLSSVK GTGPDGRILK ADIEDYLASV
310 320 330 340 350
AKGGKSESFA ASGLDYTDIP NAQIRKVTAN RLLTSKQTIP HYYLTVDTCV
360 370 380 390 400
DKLIKLRGEL NPLQDASGGK KISINDLVIK AAALALRKVP QCNSSWMNDF
410 420 430 440 450
IRQYNNVNIN VAVQTEHGLF VPVIKDADKK GLGTIAEEVK QLAQRARDNS
460 470 480 490 500
LKPADYEGGT FTVSNLGGPF GIKQFCAIIN PPQSAILAIG SAEKRVIPGG
510 520 530 540
ADGQYEFGSF MSVTMSCDHR VIDGAIGAEF LKAFKGYVEN PTTMLL
Length:546
Mass (Da):58,777
Last modified:June 13, 2012 - v1
Checksum:iEC5FD7735FCCC5F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000882 Genomic DNA. Translation: KQJ92812.1.
RefSeqiXP_003570870.1. XM_003570822.3.

Genome annotation databases

EnsemblPlantsiBRADI3G00857.2; BRADI3G00857.2; BRADI3G00857.
GeneIDi100830020.
GrameneiBRADI3G00857.2; BRADI3G00857.2; BRADI3G00857.
KEGGibdi:100830020.

Similar proteinsi

Entry informationi

Entry nameiI1HW51_BRADI
AccessioniPrimary (citable) accession number: I1HW51
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported