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I1HPZ8

- I1HPZ8_BRADI

UniProt

I1HPZ8 - I1HPZ8_BRADI

Protein

Isocitrate dehydrogenase [NADP]

Gene

BRADI2G45420

Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 11 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791SubstrateUniRule annotation
    Binding sitei84 – 841NADP
    Binding sitei111 – 1111SubstrateUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Sitei141 – 1411Critical for catalysisUniRule annotation
    Sitei212 – 2121Critical for catalysisUniRule annotation
    Metal bindingi252 – 2521Magnesium or manganeseUniRule annotation
    Binding sitei260 – 2601NADP
    Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation
    Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi77 – 793NADP
    Nucleotide bindingi310 – 3156NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:BRADI2G45420Imported
    OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
    Taxonomic identifieri15368 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeBrachypodieaeBrachypodium
    ProteomesiUP000008810: Chromosome 2

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni96 – 1027Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I1HPZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFEKIKVAN PIVEMDGDEM TRVFWQSIKD KLIFPFLDLD IKYYDLGVLH    50
    RDATDDKVTV EAAEATLKYN VAIKCATITP DEDRVKEFNL KQMWRSPNGT 100
    IRNIINGTVF REPIICKNVP KLVPGWTKPI CIGRHAFGDQ YRATDAVLKG 150
    PGKLRLVFEG KEETVDLEVF SFTGAGGVAL SMYNTDESIQ GFAAASMATA 200
    YDKKWPLYLS TKNTILKKYD GRFKDIFQEV YEAEWKSKFE AAGIWYEHRL 250
    IDDMVAYALK SEGGYVWACK NYDGDVQSDF LAQGFGSLGL MTSVLVCPDG 300
    KTIEAEAAHG TVTRHFRVHQ KGGETSTNSI ASIFAWTRGL AHRAKLDDNA 350
    RLLEFAQKLE DACVGTVESG KMTKDLALLV QGSSNVTRSH YLNTEEFIDA 400
    VAAELRTRLA AN 412
    Length:412
    Mass (Da):46,038
    Last modified:June 13, 2012 - v1
    Checksum:i3D9AE4FA3E67A005
    GO

    Sequence databases

    RefSeqiXP_003569476.1. XM_003569428.1.

    Genome annotation databases

    EnsemblPlantsiBRADI2G45420.1; BRADI2G45420.1; BRADI2G45420.
    GeneIDi100837485.
    KEGGibdi:100837485.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_003569476.1. XM_003569428.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi BRADI2G45420.1 ; BRADI2G45420.1 ; BRADI2G45420 .
    GeneIDi 100837485.
    KEGGi bdi:100837485.

    Phylogenomic databases

    KOi K00031.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the model grass Brachypodium distachyon."
      International Brachypodium Initiative
      Nature 463:763-768(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Bd21Imported.
    2. EnsemblPlants
      Submitted (NOV-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: cv. Bd21Imported.

    Entry informationi

    Entry nameiI1HPZ8_BRADI
    AccessioniPrimary (citable) accession number: I1HPZ8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3