SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

I1HPZ8

- I1HPZ8_BRADI

UniProt

I1HPZ8 - I1HPZ8_BRADI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Isocitrate dehydrogenase [NADP]
Gene
BRADI2G45420
Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Substrate By similarityUniRule annotation
Binding sitei84 – 841NADP By similarityUniRule annotation
Binding sitei111 – 1111Substrate By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Sitei141 – 1411Critical for catalysis By similarityUniRule annotation
Sitei212 – 2121Critical for catalysis By similarityUniRule annotation
Metal bindingi252 – 2521Magnesium or manganese By similarityUniRule annotation
Binding sitei260 – 2601NADP By similarityUniRule annotation
Metal bindingi275 – 2751Magnesium or manganese By similarityUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 793NADP By similarityUniRule annotation
Nucleotide bindingi310 – 3156NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:BRADI2G45420Imported
OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
Taxonomic identifieri15368 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeBrachypodieaeBrachypodium
ProteomesiUP000008810: Chromosome 2

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 1027Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1HPZ8-1 [UniParc]FASTAAdd to Basket

« Hide

MAFEKIKVAN PIVEMDGDEM TRVFWQSIKD KLIFPFLDLD IKYYDLGVLH    50
RDATDDKVTV EAAEATLKYN VAIKCATITP DEDRVKEFNL KQMWRSPNGT 100
IRNIINGTVF REPIICKNVP KLVPGWTKPI CIGRHAFGDQ YRATDAVLKG 150
PGKLRLVFEG KEETVDLEVF SFTGAGGVAL SMYNTDESIQ GFAAASMATA 200
YDKKWPLYLS TKNTILKKYD GRFKDIFQEV YEAEWKSKFE AAGIWYEHRL 250
IDDMVAYALK SEGGYVWACK NYDGDVQSDF LAQGFGSLGL MTSVLVCPDG 300
KTIEAEAAHG TVTRHFRVHQ KGGETSTNSI ASIFAWTRGL AHRAKLDDNA 350
RLLEFAQKLE DACVGTVESG KMTKDLALLV QGSSNVTRSH YLNTEEFIDA 400
VAAELRTRLA AN 412
Length:412
Mass (Da):46,038
Last modified:June 13, 2012 - v1
Checksum:i3D9AE4FA3E67A005
GO

Sequence databases

RefSeqiXP_003569476.1. XM_003569428.1.

Genome annotation databases

EnsemblPlantsiBRADI2G45420.1; BRADI2G45420.1; BRADI2G45420.
GeneIDi100837485.
KEGGibdi:100837485.

Cross-referencesi

Sequence databases

RefSeqi XP_003569476.1. XM_003569428.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi BRADI2G45420.1 ; BRADI2G45420.1 ; BRADI2G45420 .
GeneIDi 100837485.
KEGGi bdi:100837485.

Phylogenomic databases

KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequencing and analysis of the model grass Brachypodium distachyon."
    International Brachypodium Initiative
    Nature 463:763-768(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Bd21Imported.
  2. EnsemblPlants
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: cv. Bd21Imported.

Entry informationi

Entry nameiI1HPZ8_BRADI
AccessioniPrimary (citable) accession number: I1HPZ8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: June 11, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi