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I1HPZ8 (I1HPZ8_BRADI) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding77 – 793NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding310 – 3156NADP By similarity PIRSR PIRSR000108-4
Region96 – 1027Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2521Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2751Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site791Substrate By similarity PIRSR PIRSR000108-2
Binding site841NADP By similarity PIRSR PIRSR000108-4
Binding site1111Substrate By similarity PIRSR PIRSR000108-2
Binding site1341Substrate By similarity PIRSR PIRSR000108-2
Binding site2601NADP By similarity PIRSR PIRSR000108-4
Binding site3281NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1411Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2121Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
I1HPZ8 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: 3D9AE4FA3E67A005

FASTA41246,038
        10         20         30         40         50         60 
MAFEKIKVAN PIVEMDGDEM TRVFWQSIKD KLIFPFLDLD IKYYDLGVLH RDATDDKVTV 

        70         80         90        100        110        120 
EAAEATLKYN VAIKCATITP DEDRVKEFNL KQMWRSPNGT IRNIINGTVF REPIICKNVP 

       130        140        150        160        170        180 
KLVPGWTKPI CIGRHAFGDQ YRATDAVLKG PGKLRLVFEG KEETVDLEVF SFTGAGGVAL 

       190        200        210        220        230        240 
SMYNTDESIQ GFAAASMATA YDKKWPLYLS TKNTILKKYD GRFKDIFQEV YEAEWKSKFE 

       250        260        270        280        290        300 
AAGIWYEHRL IDDMVAYALK SEGGYVWACK NYDGDVQSDF LAQGFGSLGL MTSVLVCPDG 

       310        320        330        340        350        360 
KTIEAEAAHG TVTRHFRVHQ KGGETSTNSI ASIFAWTRGL AHRAKLDDNA RLLEFAQKLE 

       370        380        390        400        410 
DACVGTVESG KMTKDLALLV QGSSNVTRSH YLNTEEFIDA VAAELRTRLA AN 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequencing and analysis of the model grass Brachypodium distachyon."
International Brachypodium Initiative
Nature 463:763-768(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Bd21 EnsemblPlants BRADI2G45420.1.
[2]EnsemblPlants
Submitted (NOV-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: cv. Bd21 EnsemblPlants BRADI2G45420.1.

Cross-references

Sequence databases

RefSeqXP_003569476.1. XM_003569428.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsBRADI2G45420.1; BRADI2G45420.1; BRADI2G45420.
GeneID100837485.
KEGGbdi:100837485.

Phylogenomic databases

KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI1HPZ8_BRADI
AccessionPrimary (citable) accession number: I1HPZ8
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: June 11, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)