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I1H226

- I1H226_BRADI

UniProt

I1H226 - I1H226_BRADI

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Protein
Acetyltransferase component of pyruvate dehydrogenase complex
Gene
BRADI1G52260
Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: InterPro

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:BRADI1G52260Imported
OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
Taxonomic identifieri15368 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeBrachypodieaeBrachypodium
ProteomesiUP000008810: Chromosome 1

Subcellular locationi

Mitochondrion matrix By similarity UniRule annotation

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

KOiK00627.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1H226-1 [UniParc]FASTAAdd to Basket

« Hide

MALLLRHSRK LRRVHGVLDC ERGSIARHFS ASACSTTLKK EDGVSNSSLE    50
YGKKAGSLSI SQDRKSGKDT HKFKVSPQEA RGLYSSNRVL ISATGVNSLF 100
SCGQVVLARH FSSAADLPAH EEIGMPSLSP TMTEGNIARW VKKEGDKVSP 150
GEVLCEVETD KATVEMECME EGYLAKIVCG DGAKEIKVGE IIAITVEEEG 200
DIEKFKDYKA PASSAAPAES KPQSESTEPK GEEKELPKAA EPKATKTEES 250
SHSGDRVFSS PIARKLAEDN NVPLSSLKGT GPDGRILKAD IEEYLSSEAK 300
GTKKEAAAAP GLGHVDLPNS QIRKVTANRL LKSKQTIPHY YLTVDSRVDE 350
LIKLRSELNP LQDASGGKKI SINDLVIKAA ALALRKVPEC NSSWMNDFIR 400
QYHNVNINVA VQTEHGLFVP VVRDADKKGL ATIADEVKQL ALRARDNSLK 450
PEDYEGGTFT VSNLGGPFGI KQFCAIVNPP QAAILAIGSA EKRVIPGTDG 500
QFEVGSFMSA TLSCDHRVID GAIGAEWLKA FKGYLENPTT MLL 543
Length:543
Mass (Da):58,643
Last modified:June 13, 2012 - v1
Checksum:i30F07FF5186F4DD8
GO

Sequence databases

RefSeqiXP_003557278.1. XM_003557230.1.

Genome annotation databases

EnsemblPlantsiBRADI1G52260.2; BRADI1G52260.2; BRADI1G52260.
GeneIDi100823294.
KEGGibdi:100823294.

Cross-referencesi

Sequence databases

RefSeqi XP_003557278.1. XM_003557230.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi BRADI1G52260.2 ; BRADI1G52260.2 ; BRADI1G52260 .
GeneIDi 100823294.
KEGGi bdi:100823294.

Phylogenomic databases

KOi K00627.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequencing and analysis of the model grass Brachypodium distachyon."
    International Brachypodium Initiative
    Nature 463:763-768(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Bd21Imported.
  2. EnsemblPlants
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: cv. Bd21Imported.

Entry informationi

Entry nameiI1H226_BRADI
AccessioniPrimary (citable) accession number: I1H226
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: July 9, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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