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I1H226

- I1H226_BRADI

UniProt

I1H226 - I1H226_BRADI

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

BRADI1G52260

Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyruvate metabolic process Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Name:BRADI1G52260Imported
    OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
    Taxonomic identifieri15368 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeBrachypodieaeBrachypodium
    ProteomesiUP000008810: Chromosome 1

    Subcellular locationi

    Mitochondrion matrix UniRule annotation

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. pyruvate dehydrogenase complex Source: InterPro

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotation

    Phylogenomic databases

    KOiK00627.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I1H226-1 [UniParc]FASTAAdd to Basket

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    MALLLRHSRK LRRVHGVLDC ERGSIARHFS ASACSTTLKK EDGVSNSSLE    50
    YGKKAGSLSI SQDRKSGKDT HKFKVSPQEA RGLYSSNRVL ISATGVNSLF 100
    SCGQVVLARH FSSAADLPAH EEIGMPSLSP TMTEGNIARW VKKEGDKVSP 150
    GEVLCEVETD KATVEMECME EGYLAKIVCG DGAKEIKVGE IIAITVEEEG 200
    DIEKFKDYKA PASSAAPAES KPQSESTEPK GEEKELPKAA EPKATKTEES 250
    SHSGDRVFSS PIARKLAEDN NVPLSSLKGT GPDGRILKAD IEEYLSSEAK 300
    GTKKEAAAAP GLGHVDLPNS QIRKVTANRL LKSKQTIPHY YLTVDSRVDE 350
    LIKLRSELNP LQDASGGKKI SINDLVIKAA ALALRKVPEC NSSWMNDFIR 400
    QYHNVNINVA VQTEHGLFVP VVRDADKKGL ATIADEVKQL ALRARDNSLK 450
    PEDYEGGTFT VSNLGGPFGI KQFCAIVNPP QAAILAIGSA EKRVIPGTDG 500
    QFEVGSFMSA TLSCDHRVID GAIGAEWLKA FKGYLENPTT MLL 543
    Length:543
    Mass (Da):58,643
    Last modified:June 13, 2012 - v1
    Checksum:i30F07FF5186F4DD8
    GO

    Sequence databases

    RefSeqiXP_003557278.1. XM_003557230.1.

    Genome annotation databases

    EnsemblPlantsiBRADI1G52260.2; BRADI1G52260.2; BRADI1G52260.
    GeneIDi100823294.
    KEGGibdi:100823294.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_003557278.1. XM_003557230.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi BRADI1G52260.2 ; BRADI1G52260.2 ; BRADI1G52260 .
    GeneIDi 100823294.
    KEGGi bdi:100823294.

    Phylogenomic databases

    KOi K00627.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the model grass Brachypodium distachyon."
      International Brachypodium Initiative
      Nature 463:763-768(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Bd21Imported.
    2. EnsemblPlants
      Submitted (NOV-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: cv. Bd21Imported.

    Entry informationi

    Entry nameiI1H226_BRADI
    AccessioniPrimary (citable) accession number: I1H226
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3