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I1H226

- I1H226_BRADI

UniProt

I1H226 - I1H226_BRADI

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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

BRADI1G52260

Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 lipoyl cofactor covalently.UniRule annotation
  • Note: Binds 2 lipoyl cofactors covalently.UniRule annotation
  • Note: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:BRADI1G52260Imported
OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
Taxonomic identifieri15368 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeBrachypodieaeBrachypodium
ProteomesiUP000008810: Chromosome 1

Subcellular locationi

Mitochondrion matrix UniRule annotation

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

KOiK00627.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I1H226-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLLRHSRK LRRVHGVLDC ERGSIARHFS ASACSTTLKK EDGVSNSSLE
60 70 80 90 100
YGKKAGSLSI SQDRKSGKDT HKFKVSPQEA RGLYSSNRVL ISATGVNSLF
110 120 130 140 150
SCGQVVLARH FSSAADLPAH EEIGMPSLSP TMTEGNIARW VKKEGDKVSP
160 170 180 190 200
GEVLCEVETD KATVEMECME EGYLAKIVCG DGAKEIKVGE IIAITVEEEG
210 220 230 240 250
DIEKFKDYKA PASSAAPAES KPQSESTEPK GEEKELPKAA EPKATKTEES
260 270 280 290 300
SHSGDRVFSS PIARKLAEDN NVPLSSLKGT GPDGRILKAD IEEYLSSEAK
310 320 330 340 350
GTKKEAAAAP GLGHVDLPNS QIRKVTANRL LKSKQTIPHY YLTVDSRVDE
360 370 380 390 400
LIKLRSELNP LQDASGGKKI SINDLVIKAA ALALRKVPEC NSSWMNDFIR
410 420 430 440 450
QYHNVNINVA VQTEHGLFVP VVRDADKKGL ATIADEVKQL ALRARDNSLK
460 470 480 490 500
PEDYEGGTFT VSNLGGPFGI KQFCAIVNPP QAAILAIGSA EKRVIPGTDG
510 520 530 540
QFEVGSFMSA TLSCDHRVID GAIGAEWLKA FKGYLENPTT MLL
Length:543
Mass (Da):58,643
Last modified:June 13, 2012 - v1
Checksum:i30F07FF5186F4DD8
GO

Sequence databases

RefSeqiXP_003557278.1. XM_003557230.1.

Genome annotation databases

EnsemblPlantsiBRADI1G52260.2; BRADI1G52260.2; BRADI1G52260.
GeneIDi100823294.
KEGGibdi:100823294.

Cross-referencesi

Sequence databases

RefSeqi XP_003557278.1. XM_003557230.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi BRADI1G52260.2 ; BRADI1G52260.2 ; BRADI1G52260 .
GeneIDi 100823294.
KEGGi bdi:100823294.

Phylogenomic databases

KOi K00627.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequencing and analysis of the model grass Brachypodium distachyon."
    International Brachypodium Initiative
    Nature 463:763-768(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Bd21Imported.
  2. EnsemblPlants
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: cv. Bd21Imported.

Entry informationi

Entry nameiI1H226_BRADI
AccessioniPrimary (citable) accession number: I1H226
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: November 26, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3