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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

LOC100823294

Organism
Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:LOC100823294Imported
ORF Names:BRADI_1g52260v3Imported
OrganismiBrachypodium distachyon (Purple false brome) (Trachynia distachya)Imported
Taxonomic identifieri15368 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeBrachypodieaeBrachypodium
Proteomesi
  • UP000008810 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 196Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini258 – 295Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiKOG0557 Eukaryota
COG0508 LUCA
KOiK00627

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

I1H226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLRHSRK LRRVHGVLDC ERGSIARHFS ASACSTTLKK EDGVSNSSLE
60 70 80 90 100
YGKKAGSLSI SQDRKSGKDT HKFKVSPQEA RGLYSSNRVL ISATGVNSLF
110 120 130 140 150
SCGQVVLARH FSSAADLPAH EEIGMPSLSP TMTEGNIARW VKKEGDKVSP
160 170 180 190 200
GEVLCEVETD KATVEMECME EGYLAKIVCG DGAKEIKVGE IIAITVEEEG
210 220 230 240 250
DIEKFKDYKA PASSAAPAES KPQSESTEPK GEEKELPKAA EPKATKTEES
260 270 280 290 300
SHSGDRVFSS PIARKLAEDN NVPLSSLKGT GPDGRILKAD IEEYLSSEAK
310 320 330 340 350
GTKKEAAAAP GLGHVDLPNS QIRKVTANRL LKSKQTIPHY YLTVDSRVDE
360 370 380 390 400
LIKLRSELNP LQDASGGKKI SINDLVIKAA ALALRKVPEC NSSWMNDFIR
410 420 430 440 450
QYHNVNINVA VQTEHGLFVP VVRDADKKGL ATIADEVKQL ALRARDNSLK
460 470 480 490 500
PEDYEGGTFT VSNLGGPFGI KQFCAIVNPP QAAILAIGSA EKRVIPGTDG
510 520 530 540
QFEVGSFMSA TLSCDHRVID GAIGAEWLKA FKGYLENPTT MLL
Length:543
Mass (Da):58,643
Last modified:June 13, 2012 - v1
Checksum:i30F07FF5186F4DD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000880 Genomic DNA Translation: KQK20069.1
RefSeqiXP_003557278.1, XM_003557230.3

Genome annotation databases

EnsemblPlantsiBRADI1G52260.2; BRADI1G52260.2; BRADI1G52260
GeneIDi100823294
GrameneiBRADI1G52260.2; BRADI1G52260.2; BRADI1G52260
KEGGibdi:100823294

Similar proteinsi

Entry informationi

Entry nameiI1H226_BRADI
AccessioniPrimary (citable) accession number: I1H226
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health