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I0JSH9

- I0JSH9_HALH3

UniProt

I0JSH9 - I0JSH9_HALH3

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Protein

Kynureninase

Gene

kynU

Organism
Halobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269) (Sporosarcina halophila)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei103 – 1031Pyridoxal phosphateUniRule annotation
Binding sitei211 – 2111Pyridoxal phosphateUniRule annotation
Binding sitei214 – 2141Pyridoxal phosphateUniRule annotation
Binding sitei236 – 2361Pyridoxal phosphateUniRule annotation
Binding sitei265 – 2651Pyridoxal phosphateUniRule annotation
Binding sitei293 – 2931Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciHHAL866895:GLDT-3800-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:HBHAL_4763Imported
OrganismiHalobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269) (Sporosarcina halophila)Imported
Taxonomic identifieri866895 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeHalobacillus
ProteomesiUP000007397: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei237 – 2371N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1334Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

I0JSH9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKPKITLET AAKLDQKDVL HNFKKEFYTD DNRFYMDGNS LGLLSKRAEQ
60 70 80 90 100
SLLSSLEDWK THAIGGWTDG KEPWFYMSEK FGAKTAPLLG AKPEEVISTG
110 120 130 140 150
SITSNLHQLL STFYRPEGQR TKILADELNF PSDIYALKSQ LELHGMDPDE
160 170 180 190 200
HLIQVKSDNG ATLSEEDIIK EMRSDIALLL LPSVLYRSGQ LLDIEKITKA
210 220 230 240 250
AHEQGIMVGF DLAHSIGALP HNLDDWGVDF AVWCTYKYLN SGPGGVGGLY
260 270 280 290 300
VNEKHLGSKP GLAGWFSSKK DKQFDMAHDL NHAETAGAYQ MGTPHILSSA
310 320 330 340 350
PLLGSLDLFQ EADIKNVRCK SLQMTRLMLD LVYQELDGLG FQIITPLEDE
360 370 380 390 400
RRGGHISLVH SEAASICKAL KKENVVPDFR APDVIRLAPV ALYTTYKEVY
410 420
EVMMILKEIM VNETYKKYKN ERDIIA
Length:426
Mass (Da):47,758
Last modified:June 13, 2012 - v1
Checksum:i3281C3699AF84B54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE717023 Genomic DNA. Translation: CCG47101.1.
RefSeqiYP_006182372.1. NC_017668.1.

Genome annotation databases

EnsemblBacteriaiCCG47101; CCG47101; HBHAL_4763.
GeneIDi12746449.
KEGGihhd:HBHAL_4763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE717023 Genomic DNA. Translation: CCG47101.1 .
RefSeqi YP_006182372.1. NC_017668.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCG47101 ; CCG47101 ; HBHAL_4763 .
GeneIDi 12746449.
KEGGi hhd:HBHAL_4763.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci HHAL866895:GLDT-3800-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Chloride and organic osmolytes: a hybrid strategy to cope with elevated salinities by the moderately halophilic, chloride-dependent bacterium Halobacillus halophilus."
    Saum S.H., Pfeiffer F., Palm P., Rampp M., Schuster S.C., Muller V., Oesterhelt D.
    Environ. Microbiol. 15:1619-1633(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269Imported.

Entry informationi

Entry nameiI0JSH9_HALH3
AccessioniPrimary (citable) accession number: I0JSH9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3