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I0JSH9

- I0JSH9_HALH3

UniProt

I0JSH9 - I0JSH9_HALH3

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Protein
Kynureninase
Gene
kynU, HBHAL_4763
Organism
Halobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269) (Sporosarcina halophila)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei103 – 1031Pyridoxal phosphate By similarityUniRule annotation
Binding sitei211 – 2111Pyridoxal phosphate By similarityUniRule annotation
Binding sitei214 – 2141Pyridoxal phosphate By similarityUniRule annotation
Binding sitei236 – 2361Pyridoxal phosphate By similarityUniRule annotation
Binding sitei265 – 2651Pyridoxal phosphate By similarityUniRule annotation
Binding sitei293 – 2931Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciHHAL866895:GLDT-3800-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:HBHAL_4763Imported
OrganismiHalobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269) (Sporosarcina halophila)Imported
Taxonomic identifieri866895 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeHalobacillus
ProteomesiUP000007397: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei237 – 2371N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1334Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

I0JSH9-1 [UniParc]FASTAAdd to Basket

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MTKPKITLET AAKLDQKDVL HNFKKEFYTD DNRFYMDGNS LGLLSKRAEQ    50
SLLSSLEDWK THAIGGWTDG KEPWFYMSEK FGAKTAPLLG AKPEEVISTG 100
SITSNLHQLL STFYRPEGQR TKILADELNF PSDIYALKSQ LELHGMDPDE 150
HLIQVKSDNG ATLSEEDIIK EMRSDIALLL LPSVLYRSGQ LLDIEKITKA 200
AHEQGIMVGF DLAHSIGALP HNLDDWGVDF AVWCTYKYLN SGPGGVGGLY 250
VNEKHLGSKP GLAGWFSSKK DKQFDMAHDL NHAETAGAYQ MGTPHILSSA 300
PLLGSLDLFQ EADIKNVRCK SLQMTRLMLD LVYQELDGLG FQIITPLEDE 350
RRGGHISLVH SEAASICKAL KKENVVPDFR APDVIRLAPV ALYTTYKEVY 400
EVMMILKEIM VNETYKKYKN ERDIIA 426
Length:426
Mass (Da):47,758
Last modified:June 13, 2012 - v1
Checksum:i3281C3699AF84B54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE717023 Genomic DNA. Translation: CCG47101.1.
RefSeqiWP_014644985.1. NC_017668.1.
YP_006182372.1. NC_017668.1.

Genome annotation databases

EnsemblBacteriaiCCG47101; CCG47101; HBHAL_4763.
GeneIDi12746449.
KEGGihhd:HBHAL_4763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE717023 Genomic DNA. Translation: CCG47101.1 .
RefSeqi WP_014644985.1. NC_017668.1.
YP_006182372.1. NC_017668.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCG47101 ; CCG47101 ; HBHAL_4763 .
GeneIDi 12746449.
KEGGi hhd:HBHAL_4763.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci HHAL866895:GLDT-3800-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Chloride and organic osmolytes: a hybrid strategy to cope with elevated salinities by the moderately halophilic, chloride-dependent bacterium Halobacillus halophilus."
    Saum S.H., Pfeiffer F., Palm P., Rampp M., Schuster S.C., Muller V., Oesterhelt D.
    Environ. Microbiol. 15:1619-1633(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269.

Entry informationi

Entry nameiI0JSH9_HALH3
AccessioniPrimary (citable) accession number: I0JSH9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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