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Protein

Thymidine kinase

Gene

tdk

Organism
Halobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269) (Sporosarcina halophila)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi150ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1
Metal bindingi188ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24ATPUniRule annotation8
Nucleotide bindingi90 – 93ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:HBHAL_4623Imported
OrganismiHalobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269) (Sporosarcina halophila)Imported
Taxonomic identifieri866895 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeHalobacillus
Proteomesi
  • UP000007397 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

I0JS40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVYVMKQSG WVEVICGSMF SGKSEELIRR VRRATFGNLT VRVYKPAVDD
60 70 80 90 100
RYKEDAVVSH NGTSVLARPM KESLDILNDV GEEVDIVGID EVQFFDEHIV
110 120 130 140 150
EVAECLADRG IRVITAGLDT DFRGEPFGKM PEMMALSESI TKLNAICPIC
160 170 180 190 200
GSPASRTQRL IDGKPASYHD PIILVGASES YEPRCRHHHE VPHKPRQQQV

KAAYAERK
Length:208
Mass (Da):23,301
Last modified:June 13, 2012 - v1
Checksum:iACCCED8E6CB223DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE717023 Genomic DNA Translation: CCG46961.1

Genome annotation databases

EnsemblBacteriaiCCG46961; CCG46961; HBHAL_4623
KEGGihhd:HBHAL_4623
PATRICifig|866895.3.peg.3656

Similar proteinsi

Entry informationi

Entry nameiI0JS40_HALH3
AccessioniPrimary (citable) accession number: I0JS40
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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