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I0JDZ2

- I0JDZ2_STAAU

UniProt

I0JDZ2 - I0JDZ2_STAAU

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Protein

Isocitrate dehydrogenase [NADP]

Gene

citC

Organism
Staphylococcus aureus subsp. aureus HO 5096 0412
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSAUR1074252:GLKL-1644-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:citCImported
ORF Names:SAEMRSA15_16040Imported
OrganismiStaphylococcus aureus subsp. aureus HO 5096 0412Imported
Taxonomic identifieri1074252 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000005210: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0JDZ2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN
60 70 80 90 100
GEKRIEWKEV LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG
110 120 130 140 150
IRSLNVALRQ ELDLFTCLRP VRWFKGVPSP VKRPQDVDMV IFRENTEDIY
160 170 180 190 200
AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF PETSGIGIKP VSKEGTERLV
210 220 230 240 250
RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL TEFGDQVFTW
260 270 280 290 300
QQYDEIVEKE GRDAANSAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD
310 320 330 340 350
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY
360 370 380 390 400
AGLNKVNPSS VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR
410 420
LMDGAEEVST SAFADELIKN LK
Length:422
Mass (Da):46,467
Last modified:June 13, 2012 - v1
Checksum:i65A47019E1B42AF7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE681097 Genomic DNA. Translation: CCG16315.1.
RefSeqiYP_006237947.1. NC_017763.1.

Genome annotation databases

EnsemblBacteriaiCCG16315; CCG16315; SAEMRSA15_16040.
GeneIDi12800363.
KEGGisux:SAEMRSA15_16040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE681097 Genomic DNA. Translation: CCG16315.1 .
RefSeqi YP_006237947.1. NC_017763.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCG16315 ; CCG16315 ; SAEMRSA15_16040 .
GeneIDi 12800363.
KEGGi sux:SAEMRSA15_16040.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci SAUR1074252:GLKL-1644-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HO 5096 0412Imported.

Entry informationi

Entry nameiI0JDZ2_STAAU
AccessioniPrimary (citable) accession number: I0JDZ2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3