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I0JDZ2 (I0JDZ2_STAAU) Unreviewed, UniProtKB/TrEMBL

Last modified January 22, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Name:citC EMBL CCG16315.1
ORF Names:SAEMRSA15_16040 EMBL CCG16315.1
OrganismStaphylococcus aureus subsp. aureus HO 5096 0412 [Complete proteome] EMBL CCG16315.1
Taxonomic identifier1074252 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
I0JDZ2 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: 65A47019E1B42AF7

FASTA42246,467
        10         20         30         40         50         60 
MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN GEKRIEWKEV 

        70         80         90        100        110        120 
LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG IRSLNVALRQ ELDLFTCLRP 

       130        140        150        160        170        180 
VRWFKGVPSP VKRPQDVDMV IFRENTEDIY AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF 

       190        200        210        220        230        240 
PETSGIGIKP VSKEGTERLV RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL 

       250        260        270        280        290        300 
TEFGDQVFTW QQYDEIVEKE GRDAANSAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD 

       310        320        330        340        350        360 
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY AGLNKVNPSS 

       370        380        390        400        410        420 
VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR LMDGAEEVST SAFADELIKN 


LK 

« Hide

References

[1]Aslett M.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HO 5096 0412 EMBL CCG16315.1.
[2]"A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic."
Holden M.T., Hsu L.Y., Kurt K., Weinert L.A., Mather A.E., Harris S.R., Strommenger B., Layer F., Witte W., de Lencastre H., Skov R., Westh H., Zemlickova H., Coombs G., Kearns A.M., Hill R.L., Edgeworth J., Gould I. expand/collapse author list , Gant V., Cooke J., Edwards G.F., McAdam P.R., Templeton K.E., McCann A., Zhou Z., Castillo-Ramirez S., Feil E.J., Hudson L.O., Enright M.C., Balloux F., Aanensen D.M., Spratt B.G., Fitzgerald J.R., Parkhill J., Achtman M., Bentley S.D., Nubel U.
Genome Res. 23:653-664(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HO 5096 0412 EMBL CCG16315.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE681097 Genomic DNA. Translation: CCG16315.1.
RefSeqYP_006237947.1. NC_017763.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCG16315; CCG16315; SAEMRSA15_16040.
GeneID12800363.
KEGGsux:SAEMRSA15_16040.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Enzyme and pathway databases

BioCycSAUR1074252:GLKL-1644-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI0JDZ2_STAAU
AccessionPrimary (citable) accession number: I0JDZ2
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: January 22, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)