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Protein

Glutamate decarboxylase

Gene

LFE_0950

Organism
Leptospirillum ferrooxidans (strain C2-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciLFER1162668:GLFM-947-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:LFE_0950Imported
OrganismiLeptospirillum ferrooxidans (strain C2-3)Imported
Taxonomic identifieri1162668 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeLeptospirillum
ProteomesiUP000007382 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

I0IN05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRRHHAKK NEEFLTPTYG TRFFTNDLEA FRMSEKGTNP QSAYQIIHDE
60 70 80 90 100
LDLDGNPSLN LASFVTTWME PEAQKLISEN LQKNLVDQSE YPQTGQIQHR
110 120 130 140 150
VIHMLASLFH APEDQDVTGT STIGSSEAIL LGLLAHKKKW QFNRKKKGLS
160 170 180 190 200
TEFPNLVVGG DVHVVWEKFC RYFDVELRIV PLSRNRFILD VNEALSMVDE
210 220 230 240 250
NTIAVGAVLG TTFTGQMDPI EALNESLEKR YREKGYFVPI HVDGASGGFL
260 270 280 290 300
LPFLEPEFVW DFRLSHVRSI NVSGHKFGLV YPGVGWLLFR DRSDLPDDLV
310 320 330 340 350
FRVNYLGAEE ETYTLNFSSN AAFVIAQYYN LLRLGKQGYR QILNNCLDNA
360 370 380 390 400
RFFAGKLEKS SFFVPIDPNP SLPIVAFSLR SPHGGREMEI SAELKKFGWI
410 420 430 440 450
VPAYTLPPKA ETISVLRVVV REQVSRNMLE HLLEHLDISS RILKNPSLQT

HESPPVC
Length:457
Mass (Da):51,956
Last modified:June 13, 2012 - v1
Checksum:iBD3EE5D8B4F27512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012342 Genomic DNA. Translation: BAM06654.1.
RefSeqiWP_014449145.1. NC_017094.1.
YP_005468784.1. NC_017094.1.

Genome annotation databases

EnsemblBacteriaiBAM06654; BAM06654; LFE_0950.
KEGGilfc:LFE_0950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012342 Genomic DNA. Translation: BAM06654.1.
RefSeqiWP_014449145.1. NC_017094.1.
YP_005468784.1. NC_017094.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAM06654; BAM06654; LFE_0950.
KEGGilfc:LFE_0950.

Phylogenomic databases

KOiK01580.

Enzyme and pathway databases

BioCyciLFER1162668:GLFM-947-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the pioneer microbe on fresh volcanic deposit, Leptospirillum ferrooxidans strain C2-3."
    Fujimura R., Sato Y., Nishizawa T., Nanba K., Oshima K., Hattori M., Kamijo T., Ohta H.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C2-3Imported.

Entry informationi

Entry nameiI0IN05_LEPFC
AccessioniPrimary (citable) accession number: I0IN05
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: April 1, 2015
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.