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Protein

DNA ligase

Gene

LFE_0739

Organism
Leptospirillum ferrooxidans (strain C2-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLFER1162668:GLFM-737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:LFE_0739Imported
OrganismiLeptospirillum ferrooxidans (strain C2-3)Imported
Taxonomic identifieri1162668 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeLeptospirillum
ProteomesiUP000007382 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0IMF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFCIDEISE DFSKMEAIKG RTELAGILGN LFLRCDEEEI APLVYVVQGQ
60 70 80 90 100
LSPPFRGEPM GMASRLLIRA LSEVKAKKTF SDLNPEEAKK MEKSLDVMLA
110 120 130 140 150
HLGDPGALAQ EVLSQNSPSR LSFLDVFRIL ERLSQMEGEG SQVDKVSELA
160 170 180 190 200
TLLSRLSPLS ARFVARFVMG KLRLGVGDST IIEALAVSGG GRATKSIVEK
210 220 230 240 250
AYNICSDLGL VGRKIKQGGL ESLSSLEPSP GFPIRVALCE RLSSGEDIIA
260 270 280 290 300
KIGRCSIESK YDGFRCQIHI IAGKVEIFSR NLDSMTSMFP EIVRATKEIF
310 320 330 340 350
GNRSAIFEGE ALGIDPETGT YQPFQVTITR KRKHNVLEKS LEIPLRLLVF
360 370 380 390 400
DLLYLDGVSW MERPFFERRA KVETLFGAEK FDILEVERPP AGVIGSSRLI
410 420 430 440 450
FTDEASKVNE FFEEVVEEGF EGIIAKRLDG IYTAGSRNFN WIKLKKSYQG
460 470 480 490 500
KISDTLDLVI IGYYLGKGQR LKLGIGAILA AVWDRDSKSF ASIARIGSGL
510 520 530 540 550
TEEKWMMLSA MLREIVVPER PVDVMSDVVP DFWVLPRFVV TVRADEISRS
560 570 580 590 600
SMHAAGRDYL SNTEGTPEGY ALRFPRMVSF VRADKKPEDA TEVSEIVSLF
610 620
DLQRSLSQRS QREKPSSVRK
Length:620
Mass (Da):68,987
Last modified:June 13, 2012 - v1
Checksum:iBE0E0FF6920BA43C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012342 Genomic DNA. Translation: BAM06454.1.
RefSeqiWP_014448946.1. NC_017094.1.
YP_005468584.1. NC_017094.1.

Genome annotation databases

EnsemblBacteriaiBAM06454; BAM06454; LFE_0739.
KEGGilfc:LFE_0739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012342 Genomic DNA. Translation: BAM06454.1.
RefSeqiWP_014448946.1. NC_017094.1.
YP_005468584.1. NC_017094.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAM06454; BAM06454; LFE_0739.
KEGGilfc:LFE_0739.

Phylogenomic databases

KOiK10747.

Enzyme and pathway databases

BioCyciLFER1162668:GLFM-737-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the pioneer microbe on fresh volcanic deposit, Leptospirillum ferrooxidans strain C2-3."
    Fujimura R., Sato Y., Nishizawa T., Nanba K., Oshima K., Hattori M., Kamijo T., Ohta H.
    Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C2-3Imported.

Entry informationi

Entry nameiI0IMF5_LEPFC
AccessioniPrimary (citable) accession number: I0IMF5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: April 29, 2015
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.