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I0ICX5

- I0ICX5_PHYMF

UniProt

I0ICX5 - I0ICX5_PHYMF

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Protein

Alanine racemase

Gene
alr, PSMK_09540
Organism
Phycisphaera mikurensis (strain NBRC 102666 / KCTC 22515 / FYK2301M01)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei140 – 1401Substrate By similarityUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciPMIK1142394:GLIF-966-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:PSMK_09540Imported
OrganismiPhycisphaera mikurensis (strain NBRC 102666 / KCTC 22515 / FYK2301M01)Imported
Taxonomic identifieri1142394 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPhycisphaeraePhycisphaeralesPhycisphaeraceaePhycisphaera
ProteomesiUP000007881: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI0ICX5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

I0ICX5-1 [UniParc]FASTAAdd to Basket

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MAAPPTSNSW LEVDLAAVEA NARVLAAAAP AASLCGVVKK DAYGLGGPAV    50
GRALEAAGAG MLAVYEPREA LAIAEAGVGL PFLVLHGTLA AGDPWAALAE 100
AGRLEFQAGD GELLDALDAE GRRRGIRLPV HVHADTGMSR EGMPGPAAVD 150
AVRGIPARAG LRLAGVMTHL ATADSDARRA AGQVAAFDRL LAQMELPEHA 200
VVHLCNSYAA MREPAWHRRM IRPGIGLYGY AEPTLDRGER WETDARLRPV 250
ARWVSRIARV LDASAGAPVG YGATESLEKD TRLGLVPVGY ADGYPLALSG 300
RGVVRVGGAE CRVVGRVSMD QVMVDLSAAP GAGPGAEVEV YGNDPAAPNA 350
LPRMAAAAGS HAYELLTRIH PRVERRHAVA RPGFGDPPDA G 391
Length:391
Mass (Da):40,577
Last modified:June 13, 2012 - v1
Checksum:i894F03151D73BD77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012338 Genomic DNA. Translation: BAM03113.1.
RefSeqiYP_005445010.1. NC_017080.1.

Genome annotation databases

EnsemblBacteriaiBAM03113; BAM03113; PSMK_09540.
GeneIDi12037444.
KEGGiphm:PSMK_09540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012338 Genomic DNA. Translation: BAM03113.1 .
RefSeqi YP_005445010.1. NC_017080.1.

3D structure databases

ProteinModelPortali I0ICX5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAM03113 ; BAM03113 ; PSMK_09540 .
GeneIDi 12037444.
KEGGi phm:PSMK_09540.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci PMIK1142394:GLIF-966-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Phycisphaera mikurensis NBRC 102666."
    Ankai A., Hosoyama A., Terui Y., Sekine M., Fukai R., Kato Y., Nakamura S., Yamada-Narita S., Kawakoshi A., Fukunaga Y., Yamazaki S., Fujita N.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBRC 102666 / KCTC 22515 / FYK2301M01.

Entry informationi

Entry nameiI0ICX5_PHYMF
AccessioniPrimary (citable) accession number: I0ICX5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: July 9, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3