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Protein

Thymidine kinase

Gene

tdk

Organism
Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi151ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1
Metal bindingi189ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24ATPUniRule annotation8
Nucleotide bindingi91 – 94ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:CLDAP_20620Imported
OrganismiCaldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)Imported
Taxonomic identifieri926550 [NCBI]
Taxonomic lineageiBacteriaChloroflexiCaldilineaeCaldilinealesCaldilineaceaeCaldilinea
Proteomesi
  • UP000007880 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

I0I4B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMHPVHPSDG RIELICGSMF SGKTEELLRR IRRAEIARKK VQLFKPAIDN
60 70 80 90 100
RYGLVRIASH NGLAREDAVV VACAQEIVER LEPDTEVVAI DEVQFFDEAV
110 120 130 140 150
VEVCDHLANR GLRVIVAGLD QDFRGEPFGP MPRLMALAEM VDKLQAICVI
160 170 180 190
CGAPASRTQR LIDGKPARYD DPVILVGGSE RYEARCRACH EVPGKP
Length:196
Mass (Da):21,771
Last modified:June 13, 2012 - v1
Checksum:i2E690C9502924E09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012337 Genomic DNA Translation: BAM00102.1

Genome annotation databases

EnsemblBacteriaiBAM00102; BAM00102; CLDAP_20620
KEGGicap:CLDAP_20620
PATRICifig|926550.5.peg.2277

Similar proteinsi

Entry informationi

Entry nameiI0I4B4_CALAS
AccessioniPrimary (citable) accession number: I0I4B4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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