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I0I4B4

- I0I4B4_CALAS

UniProt

I0I4B4 - I0I4B4_CALAS

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Protein
Thymidine kinase
Gene
tdk, CLDAP_20620
Organism
Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Proton acceptor By similarityUniRule annotation
Metal bindingi148 – 1481Zinc By similarityUniRule annotation
Metal bindingi151 – 1511Zinc By similarityUniRule annotation
Metal bindingi186 – 1861Zinc By similarityUniRule annotation
Metal bindingi189 – 1891Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248ATP By similarityUniRule annotation
Nucleotide bindingi91 – 944ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCAER926550:GLA5-2099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:CLDAP_20620Imported
OrganismiCaldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)Imported
Taxonomic identifieri926550 [NCBI]
Taxonomic lineageiBacteriaChloroflexiCaldilineaeCaldilinealesCaldilineaceaeCaldilinea
ProteomesiUP000007880: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0I4B4-1 [UniParc]FASTAAdd to Basket

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MMHPVHPSDG RIELICGSMF SGKTEELLRR IRRAEIARKK VQLFKPAIDN    50
RYGLVRIASH NGLAREDAVV VACAQEIVER LEPDTEVVAI DEVQFFDEAV 100
VEVCDHLANR GLRVIVAGLD QDFRGEPFGP MPRLMALAEM VDKLQAICVI 150
CGAPASRTQR LIDGKPARYD DPVILVGGSE RYEARCRACH EVPGKP 196
Length:196
Mass (Da):21,771
Last modified:June 13, 2012 - v1
Checksum:i2E690C9502924E09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012337 Genomic DNA. Translation: BAM00102.1.
RefSeqiWP_014433337.1. NC_017079.1.
YP_005441999.1. NC_017079.1.

Genome annotation databases

EnsemblBacteriaiBAM00102; BAM00102; CLDAP_20620.
GeneIDi12033948.
KEGGicap:CLDAP_20620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012337 Genomic DNA. Translation: BAM00102.1 .
RefSeqi WP_014433337.1. NC_017079.1.
YP_005441999.1. NC_017079.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAM00102 ; BAM00102 ; CLDAP_20620 .
GeneIDi 12033948.
KEGGi cap:CLDAP_20620.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci CAER926550:GLA5-2099-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Caldilinea aerophila DSM 14535 (= NBRC 102666)."
    Oguchi A., Hosoyama A., Sekine M., Fukai R., Kato Y., Nakamura S., Hanada S., Yamazaki S., Fujita N.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1.

Entry informationi

Entry nameiI0I4B4_CALAS
AccessioniPrimary (citable) accession number: I0I4B4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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