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Protein

Acetylornithine aminotransferase

Gene

gabT

Organism
Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Catalytic activityi

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD), Acetylornithine aminotransferase (argD), Acetylornithine aminotransferase (gabT)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei153Pyridoxal phosphate; via carbonyl oxygenUniRule annotation1
Binding sitei156N2-acetyl-L-ornithineUniRule annotation1
Binding sitei320Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:gabTImported
Synonyms:argDUniRule annotation
Ordered Locus Names:CLDAP_19050Imported
OrganismiCaldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)Imported
Taxonomic identifieri926550 [NCBI]
Taxonomic lineageiBacteriaChloroflexiCaldilineaeCaldilinealesCaldilineaceaeCaldilinea
Proteomesi
  • UP000007880 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei292N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI0I3V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 127Pyridoxal phosphate bindingUniRule annotation2
Regioni263 – 266Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

KOiK00823.
OMAiGIATCTL.
OrthoDBiPOG091H0APS.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3. 1 hit.
InterProiView protein in InterPro
IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 2 hits.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

I0I3V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLATHLTRTI PRLNTPGPKA RAILERDRAV VSRAYGRVAD FVMSHGLGSQ
60 70 80 90 100
VWDVDGNRYL DFMSGIAVNA TGHSHPRVVR AIQEQAEKFL HISSDYYHES
110 120 130 140 150
WVRLSERLNE IAPFAEPSSV FLGNSGTEAV EGAIKLARYH TGRPYFLGFI
160 170 180 190 200
GGFHGRTLGS LGFTASKITQ RRGFLPQREV IHVPYPYEYR PLLAMQPGEA
210 220 230 240 250
DYGETVVNYI ERVVFKNLVA PDEVAAVVVE PIQGEGGYVV PPASFFPRLR
260 270 280 290 300
ELCDRHGILL IVDEVQSGMG RTGKWWAIEH WGVEPDIVCT AKGIASGVPL
310 320 330 340 350
GGFIARQRIA TWPTGAHGNT YGGNPLAMVA ALATMEVLEN GGIQNAAEQG
360 370 380 390 400
AYMLSRLNEM AARHPSIGDV RGKGLMIGVE FVQDKATRMP NARLRDRIVE
410 420 430 440 450
LAFEHGLLIM GCGVSTMRII PPLIITRPEV DEGLEIFEYA VTLAEEELMG
Length:450
Mass (Da):49,486
Last modified:June 13, 2012 - v1
Checksum:i9F9049CDA32C8B7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012337 Genomic DNA. Translation: BAL99944.1.
RefSeqiWP_014433180.1. NC_017079.1.

Genome annotation databases

EnsemblBacteriaiBAL99944; BAL99944; CLDAP_19050.
KEGGicap:CLDAP_19050.
PATRICifig|926550.5.peg.2115.

Similar proteinsi

Entry informationi

Entry nameiI0I3V7_CALAS
AccessioniPrimary (citable) accession number: I0I3V7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: September 27, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported