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I0I3V7

- I0I3V7_CALAS

UniProt

I0I3V7 - I0I3V7_CALAS

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Protein

Acetylornithine aminotransferase

Gene

gabT

Organism
Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Note: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei153 – 1531Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei156 – 1561N2-acetyl-L-ornithineUniRule annotation
Binding sitei320 – 3201Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCAER926550:GLA5-1942-MONOMER.
UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:gabTImported
Synonyms:argDUniRule annotation
Ordered Locus Names:CLDAP_19050Imported
OrganismiCaldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)Imported
Taxonomic identifieri926550 [NCBI]
Taxonomic lineageiBacteriaChloroflexiCaldilineaeCaldilinealesCaldilineaceaeCaldilinea
ProteomesiUP000007880: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei292 – 2921N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1272Pyridoxal phosphate bindingUniRule annotation
Regioni263 – 2664Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

KOiK00823.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0I3V7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLATHLTRTI PRLNTPGPKA RAILERDRAV VSRAYGRVAD FVMSHGLGSQ
60 70 80 90 100
VWDVDGNRYL DFMSGIAVNA TGHSHPRVVR AIQEQAEKFL HISSDYYHES
110 120 130 140 150
WVRLSERLNE IAPFAEPSSV FLGNSGTEAV EGAIKLARYH TGRPYFLGFI
160 170 180 190 200
GGFHGRTLGS LGFTASKITQ RRGFLPQREV IHVPYPYEYR PLLAMQPGEA
210 220 230 240 250
DYGETVVNYI ERVVFKNLVA PDEVAAVVVE PIQGEGGYVV PPASFFPRLR
260 270 280 290 300
ELCDRHGILL IVDEVQSGMG RTGKWWAIEH WGVEPDIVCT AKGIASGVPL
310 320 330 340 350
GGFIARQRIA TWPTGAHGNT YGGNPLAMVA ALATMEVLEN GGIQNAAEQG
360 370 380 390 400
AYMLSRLNEM AARHPSIGDV RGKGLMIGVE FVQDKATRMP NARLRDRIVE
410 420 430 440 450
LAFEHGLLIM GCGVSTMRII PPLIITRPEV DEGLEIFEYA VTLAEEELMG
Length:450
Mass (Da):49,486
Last modified:June 13, 2012 - v1
Checksum:i9F9049CDA32C8B7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012337 Genomic DNA. Translation: BAL99944.1.
RefSeqiYP_005441842.1. NC_017079.1.

Genome annotation databases

EnsemblBacteriaiBAL99944; BAL99944; CLDAP_19050.
GeneIDi12033791.
KEGGicap:CLDAP_19050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012337 Genomic DNA. Translation: BAL99944.1 .
RefSeqi YP_005441842.1. NC_017079.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAL99944 ; BAL99944 ; CLDAP_19050 .
GeneIDi 12033791.
KEGGi cap:CLDAP_19050.

Phylogenomic databases

KOi K00823.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00109 .
BioCyci CAER926550:GLA5-1942-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Caldilinea aerophila DSM 14535 (= NBRC 102666)."
    Oguchi A., Hosoyama A., Sekine M., Fukai R., Kato Y., Nakamura S., Hanada S., Yamazaki S., Fujita N.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1Imported.

Entry informationi

Entry nameiI0I3V7_CALAS
AccessioniPrimary (citable) accession number: I0I3V7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: November 26, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3