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Protein

Alanine racemase

Gene

alr

Organism
Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei282 – 2821Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei330 – 3301Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCAER926550:GLA5-1267-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CLDAP_12500Imported
OrganismiCaldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)Imported
Taxonomic identifieri926550 [NCBI]
Taxonomic lineageiBacteriaChloroflexiCaldilineaeCaldilinealesCaldilineaceaeCaldilinea
ProteomesiUP000007880 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI0I202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0I202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVEERQAEV FHPFPAESPP RPTWIEVSRS ALVNNYRLLR SRLATTTKFM
60 70 80 90 100
AVVKANAYGH GAAETARILQ GAGADAFAVA TLQEALELRA AGIERPILVL
110 120 130 140 150
GYTPASQTSL AVKHSITLTL FDLETAAAMN AIARAQAQPL IVHLKVNTGM
160 170 180 190 200
NRLGVKPPLA PQMVAALQQF EALRLEGIFT HFATADELDK RHAEAQFRRF
210 220 230 240 250
QQLLEELERN GLRPPLAHAA NSAALLTMPH THLDMVRPGI ALYGLDPDAE
260 270 280 290 300
QCRLPEGFRP ALAWKAIVVQ VSDLEPGEAV SYGREFIANR PMRIATLPVG
310 320 330 340 350
YADGFPRKPQ NWGSVLIHGR PAPILGRVCM DQCVVDVTAI ETGHGPVRQG
360 370 380 390
DEAILIGRQG DAEISAAEAG RRVGTNNYDI VSRILARVPR LYVD
Length:394
Mass (Da):42,991
Last modified:June 12, 2012 - v1
Checksum:i7B764D300600830B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012337 Genomic DNA. Translation: BAL99289.1.
RefSeqiWP_014432530.1. NC_017079.1.
YP_005441187.1. NC_017079.1.

Genome annotation databases

EnsemblBacteriaiBAL99289; BAL99289; CLDAP_12500.
GeneIDi12033116.
KEGGicap:CLDAP_12500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012337 Genomic DNA. Translation: BAL99289.1.
RefSeqiWP_014432530.1. NC_017079.1.
YP_005441187.1. NC_017079.1.

3D structure databases

ProteinModelPortaliI0I202.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAL99289; BAL99289; CLDAP_12500.
GeneIDi12033116.
KEGGicap:CLDAP_12500.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCAER926550:GLA5-1267-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Caldilinea aerophila DSM 14535 (= NBRC 102666)."
    Oguchi A., Hosoyama A., Sekine M., Fukai R., Kato Y., Nakamura S., Hanada S., Yamazaki S., Fujita N.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1Imported.

Entry informationi

Entry nameiI0I202_CALAS
AccessioniPrimary (citable) accession number: I0I202
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2012
Last sequence update: June 12, 2012
Last modified: March 31, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.