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I0I202

- I0I202_CALAS

UniProt

I0I202 - I0I202_CALAS

Protein

Alanine racemase

Gene

alr

Organism
Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei54 – 541Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei152 – 1521SubstrateUniRule annotation
    Active sitei282 – 2821Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei330 – 3301Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCAER926550:GLA5-1267-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:CLDAP_12500Imported
    OrganismiCaldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)Imported
    Taxonomic identifieri926550 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiCaldilineaeCaldilinealesCaldilineaceaeCaldilinea
    ProteomesiUP000007880: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliI0I202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I0I202-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVEERQAEV FHPFPAESPP RPTWIEVSRS ALVNNYRLLR SRLATTTKFM    50
    AVVKANAYGH GAAETARILQ GAGADAFAVA TLQEALELRA AGIERPILVL 100
    GYTPASQTSL AVKHSITLTL FDLETAAAMN AIARAQAQPL IVHLKVNTGM 150
    NRLGVKPPLA PQMVAALQQF EALRLEGIFT HFATADELDK RHAEAQFRRF 200
    QQLLEELERN GLRPPLAHAA NSAALLTMPH THLDMVRPGI ALYGLDPDAE 250
    QCRLPEGFRP ALAWKAIVVQ VSDLEPGEAV SYGREFIANR PMRIATLPVG 300
    YADGFPRKPQ NWGSVLIHGR PAPILGRVCM DQCVVDVTAI ETGHGPVRQG 350
    DEAILIGRQG DAEISAAEAG RRVGTNNYDI VSRILARVPR LYVD 394
    Length:394
    Mass (Da):42,991
    Last modified:June 13, 2012 - v1
    Checksum:i7B764D300600830B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012337 Genomic DNA. Translation: BAL99289.1.
    RefSeqiYP_005441187.1. NC_017079.1.

    Genome annotation databases

    EnsemblBacteriaiBAL99289; BAL99289; CLDAP_12500.
    GeneIDi12033116.
    KEGGicap:CLDAP_12500.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012337 Genomic DNA. Translation: BAL99289.1 .
    RefSeqi YP_005441187.1. NC_017079.1.

    3D structure databases

    ProteinModelPortali I0I202.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAL99289 ; BAL99289 ; CLDAP_12500 .
    GeneIDi 12033116.
    KEGGi cap:CLDAP_12500.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CAER926550:GLA5-1267-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Caldilinea aerophila DSM 14535 (= NBRC 102666)."
      Oguchi A., Hosoyama A., Sekine M., Fukai R., Kato Y., Nakamura S., Hanada S., Yamazaki S., Fujita N.
      Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1Imported.

    Entry informationi

    Entry nameiI0I202_CALAS
    AccessioniPrimary (citable) accession number: I0I202
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3