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I0I202

- I0I202_CALAS

UniProt

I0I202 - I0I202_CALAS

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Protein

Alanine racemase

Gene

alr

Organism
Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei282 – 2821Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei330 – 3301Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCAER926550:GLA5-1267-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CLDAP_12500Imported
OrganismiCaldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)Imported
Taxonomic identifieri926550 [NCBI]
Taxonomic lineageiBacteriaChloroflexiCaldilineaeCaldilinealesCaldilineaceaeCaldilinea
ProteomesiUP000007880: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI0I202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0I202-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVEERQAEV FHPFPAESPP RPTWIEVSRS ALVNNYRLLR SRLATTTKFM
60 70 80 90 100
AVVKANAYGH GAAETARILQ GAGADAFAVA TLQEALELRA AGIERPILVL
110 120 130 140 150
GYTPASQTSL AVKHSITLTL FDLETAAAMN AIARAQAQPL IVHLKVNTGM
160 170 180 190 200
NRLGVKPPLA PQMVAALQQF EALRLEGIFT HFATADELDK RHAEAQFRRF
210 220 230 240 250
QQLLEELERN GLRPPLAHAA NSAALLTMPH THLDMVRPGI ALYGLDPDAE
260 270 280 290 300
QCRLPEGFRP ALAWKAIVVQ VSDLEPGEAV SYGREFIANR PMRIATLPVG
310 320 330 340 350
YADGFPRKPQ NWGSVLIHGR PAPILGRVCM DQCVVDVTAI ETGHGPVRQG
360 370 380 390
DEAILIGRQG DAEISAAEAG RRVGTNNYDI VSRILARVPR LYVD
Length:394
Mass (Da):42,991
Last modified:June 13, 2012 - v1
Checksum:i7B764D300600830B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012337 Genomic DNA. Translation: BAL99289.1.
RefSeqiWP_014432530.1. NC_017079.1.
YP_005441187.1. NC_017079.1.

Genome annotation databases

EnsemblBacteriaiBAL99289; BAL99289; CLDAP_12500.
GeneIDi12033116.
KEGGicap:CLDAP_12500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012337 Genomic DNA. Translation: BAL99289.1 .
RefSeqi WP_014432530.1. NC_017079.1.
YP_005441187.1. NC_017079.1.

3D structure databases

ProteinModelPortali I0I202.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAL99289 ; BAL99289 ; CLDAP_12500 .
GeneIDi 12033116.
KEGGi cap:CLDAP_12500.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CAER926550:GLA5-1267-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Caldilinea aerophila DSM 14535 (= NBRC 102666)."
    Oguchi A., Hosoyama A., Sekine M., Fukai R., Kato Y., Nakamura S., Hanada S., Yamazaki S., Fujita N.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1Imported.

Entry informationi

Entry nameiI0I202_CALAS
AccessioniPrimary (citable) accession number: I0I202
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: October 29, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3