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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Rubrivivax gelatinosus (strain NBRC 100245 / IL144)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase I FolE (folE), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRGEL983917:G1H8K-1650-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:RGE_16700Imported
OrganismiRubrivivax gelatinosus (strain NBRC 100245 / IL144)Imported
Taxonomic identifieri983917 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesRubrivivax
Proteomesi
  • UP000007883 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK09007
OMAiPYSSTCP
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

I0HPS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLTDALHI PDTQSARDER HVAIQRVGVK DVRYPLQLRV AGAVQSTAAS
60 70 80 90 100
WTLDVALPAE QKGTHMSRFV AWLDALDEPL DAAALARRHA TMLEKLGARE
110 120 130 140 150
GRVEAAFSFF LRKRAPVSGL QSLLDYQGRW IAETRLDGET TKTTLWAEVA
160 170 180 190 200
VPVKSLCPCS KEISDYGAHN QRSIVTIRIE LLQPVEWHEL VRFAEDEASS
210 220 230 240 250
EIWPMLKRGD EKWVTERAYE NPKFVEDLVR DVALRLNRDA RIGRYVVDVE
260
NFESIHNHSA WARIER
Length:266
Mass (Da):30,279
Last modified:June 13, 2012 - v1
Checksum:iBE14F60E3B121A29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012320 Genomic DNA Translation: BAL95011.1
RefSeqiWP_014427875.1, NC_017075.1

Genome annotation databases

EnsemblBacteriaiBAL95011; BAL95011; RGE_16700
KEGGirge:RGE_16700
PATRICifig|983917.3.peg.1633

Similar proteinsi

Entry informationi

Entry nameiI0HPS4_RUBGI
AccessioniPrimary (citable) accession number: I0HPS4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: February 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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