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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotationSAAS annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (AMIS_15730)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei61SubstrateUniRule annotation1
Active sitei88Proton donor/acceptorUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Sitei183Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
Biological processGluconeogenesisUniRule annotationSAAS annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAMIS512565:G1H8M-7535-MONOMER
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:AMIS_76010Imported
OrganismiActinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)Imported
Taxonomic identifieri512565 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeActinoplanes
Proteomesi
  • UP000007882 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliI0HII4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 16Substrate bindingUniRule annotation8
Regioni22 – 23Substrate bindingUniRule annotation2
Regioni88 – 91Substrate bindingUniRule annotation4
Regioni115 – 116Substrate bindingUniRule annotation2
Regioni184 – 185Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01834
OMAiRMLPYWY
OrthoDBiPOG091H03E2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.12401 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit

Sequencei

Sequence statusi: Complete.

I0HII4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGTLVLLRH GNSEWNAKNL FTGWVDVDLD AKGEDEARRG GELLKEQNVL
60 70 80 90 100
PDVVHTSLLR RAIRTSEIAL HLTDRHWIPV KRSWRLNERH YGALQGKDKK
110 120 130 140 150
QTLEAYGEEQ FMLWRRSYDV PPPPIEDDSE FSQFGDARYA NLPPELLPKA
160 170 180 190 200
ECLKDVLERA LPYWYDEIVP DLRAGKTVLV AAHGNSLRAI VKHLDQVSDS
210 220 230 240
AIAKLNIPTG IPLRYDLDDN LRPTNPGGEY LDPVAAKEAA AAVANQGKK
Length:249
Mass (Da):28,034
Last modified:June 13, 2012 - v1
Checksum:i2998FD659239D43B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012319 Genomic DNA Translation: BAL92821.1
RefSeqiWP_014447704.1, NC_017093.1

Genome annotation databases

EnsemblBacteriaiBAL92821; BAL92821; AMIS_76010
KEGGiams:AMIS_76010
PATRICifig|512565.3.peg.7614

Similar proteinsi

Entry informationi

Entry nameiI0HII4_ACTM4
AccessioniPrimary (citable) accession number: I0HII4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: February 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported