ID   I0HHI1_ACTM4            Unreviewed;       548 AA.
AC   I0HHI1;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Alpha-amylase {ECO:0000256|RuleBase:RU361134};
DE            EC=3.2.1.1 {ECO:0000256|RuleBase:RU361134};
GN   OrderedLocusNames=AMIS_72480 {ECO:0000313|EMBL:BAL92468.1};
OS   Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 /
OS   JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=512565 {ECO:0000313|EMBL:BAL92468.1, ECO:0000313|Proteomes:UP000007882};
RN   [1] {ECO:0000313|EMBL:BAL92468.1, ECO:0000313|Proteomes:UP000007882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 /
RC   NCIMB 12654 / NRRL B-3342 / UNCC 431
RC   {ECO:0000313|Proteomes:UP000007882};
RA   Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H.,
RA   Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.;
RT   "Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC
RT   102363).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in
CC         polysaccharides containing three or more (1->4)-alpha-linked D-
CC         glucose units.; EC=3.2.1.1; Evidence={ECO:0000256|RuleBase:RU361134};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|ARBA:ARBA00008061, ECO:0000256|RuleBase:RU003615}.
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DR   EMBL; AP012319; BAL92468.1; -; Genomic_DNA.
DR   RefSeq; WP_014447353.1; NC_017093.1.
DR   AlphaFoldDB; I0HHI1; -.
DR   STRING; 512565.AMIS_72480; -.
DR   KEGG; ams:AMIS_72480; -.
DR   PATRIC; fig|512565.3.peg.7255; -.
DR   eggNOG; COG0366; Bacteria.
DR   HOGENOM; CLU_006462_2_1_11; -.
DR   OrthoDB; 9802433at2; -.
DR   Proteomes; UP000007882; Chromosome.
DR   GO; GO:0004556; F:alpha-amylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043169; F:cation binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd11334; AmyAc_TreS; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR006046; Alpha_amylase.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR045857; O16G_dom_2.
DR   PANTHER; PTHR10357; ALPHA-AMYLASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR10357:SF219; MALTOSE ALPHA-D-GLUCOSYLTRANSFERASE; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   PRINTS; PR00110; ALPHAAMYLASE.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU361134};
KW   Glycosidase {ECO:0000256|RuleBase:RU361134};
KW   Hydrolase {ECO:0000256|RuleBase:RU361134, ECO:0000313|EMBL:BAL92468.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007882}.
FT   DOMAIN          13..396
FT                   /note="Glycosyl hydrolase family 13 catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00642"
SQ   SEQUENCE   548 AA;  62146 MW;  7141B293F7DED3A1 CRC64;
     MSDRWYENAV VYCLDIDSFA DSDGDGCGDI RGLIGRLDYL ARLGVTCLWL NPIHPSPGRD
     DGYDASDFYN VDPRFGSLGD FAELLHEAGN RGIKVIIDLV VNHTSDQHPW FQSARSSPES
     PYRDWYVWSE TAPPDRNQGM VFPGEQNETW SYDRTAKLWF YHRFYKFQPD LNIKNPAVRE
     EIKKICSFWL QLGVAGFRMD AVPFIIEETE PGNPNSPKDM NFLSELRQHV QWRRGDAVLL
     AEANVEPDQL VRFFGDEGGS GNRIHMLFDF MLNARLVLGL AREDTEPIID ALRDSPKLPE
     GGQWATFLRN HDEIDLSRLT ADQRQDVFAR FGPDEDMQLY GRGIRRRLAP MLGNDRRWLE
     LAYALQFSLR GTPVLRYGEE IGMGDDLSLK GRDAIRTPMQ WSMLPSGGFT SADPSKLGRP
     VISGGEFGFE KVNVTVQRQD PRSLLSWFER MIRTLKEAPE IGRGTCTHVD VPAPRGVLVH
     RADAATGTMV FVHNLGTEPA VVDLGSLAEE AELPNDVLAD QEYPEPGKLD EIRVEGHGYR
     WIRLRRTA
//