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I0HH16 (I0HH16_ACTM4) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain149 – 351203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding176 – 23156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3051Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3181Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3181Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3201Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I0HH16 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: FC20FD2B13081492

FASTA36138,209
        10         20         30         40         50         60 
MTTPRKTRVA IVFGGRSTEH AISCVSAGAI LGALDPDQYE AVPVGITREG RWVLPTGEAS 

        70         80         90        100        110        120 
QLTIQGRTLP EITEASGSSV VLAADPTVTE LIVQDGLPSL DGVDVVFPVL HGAYGEDGTI 

       130        140        150        160        170        180 
QGMLEMAGIP YVGANVFASA AAMDKEFTKK LAAAEGIPVG PYAVLRAGVS LSEADKERLG 

       190        200        210        220        230        240 
LPVFVKPSRA GSSTGITKVT DWADLDAAVA TARQIDPKVL VEAAIVGREI ECGVLEGEAG 

       250        260        270        280        290        300 
GAPEASLLAE IHVDDADWYD FETKYLVGSR YTIPAALSPE ITRQVREFAL QTFTALDCAG 

       310        320        330        340        350        360 
LARVDFFVTP SGEIFLNEIN TMPGMTPTSM FPMMWAATGL EYPKVVDRLI RTALRRGTGL 


H 

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References

[1]"Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC 102363)."
Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H., Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP012319 Genomic DNA. Translation: BAL92303.1.
RefSeqYP_005466819.1. NC_017093.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAL92303; BAL92303; AMIS_70830.
GeneID12048843.
KEGGams:AMIS_70830.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAMDKIAMK.

Enzyme and pathway databases

BioCycAMIS512565:GL7J-7145-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI0HH16_ACTM4
AccessionPrimary (citable) accession number: I0HH16
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: February 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)