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Protein

Thymidine kinase

Gene

AMIS_56960

Organism
Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Ordered Locus Names:AMIS_56960Imported
OrganismiActinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)Imported
Taxonomic identifieri512565 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeActinoplanes
Proteomesi
  • UP000007882 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 144AAAInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiRATHNAR.
OrthoDBiPOG091H0659.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

I0HD29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVYHELTL FHGSMGAGKS TLALQNAYNR RQAGRPGVLL TSMDRAGSGV
60 70 80 90 100
LSSRLGVMAD AIEVTDGADL VTLIEAQVPA GGFVIVDEAQ FLRPEQVEQL
110 120 130 140 150
ALAVDELHVD VDCYAISTDF MSRLFPGSQR LLELADRIVS LQVEVTCWCG
160 170 180 190 200
RPGRQNARIE DGRVARSGAQ VAVGDIDAAA EVSYRVLCRR HWREGVAGPA

QG
Length:202
Mass (Da):21,720
Last modified:June 13, 2012 - v1
Checksum:iD92FA7D84C5511EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012319 Genomic DNA. Translation: BAL90916.1.
RefSeqiWP_014445804.1. NC_017093.1.

Genome annotation databases

EnsemblBacteriaiBAL90916; BAL90916; AMIS_56960.
KEGGiams:AMIS_56960.
PATRICifig|512565.3.peg.5693.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiI0HD29_ACTM4
AccessioniPrimary (citable) accession number: I0HD29
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: July 5, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported