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Protein

Glutamate decarboxylase

Gene

AMIS_46640

Organism
Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciAMIS512565:GL7J-4713-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:AMIS_46640Imported
OrganismiActinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)Imported
Taxonomic identifieri512565 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeActinoplanes
ProteomesiUP000007882 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OMAiRNADRYP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

I0HA47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSMLKHPR SERPAPEVLA TADVTIPRHE LPAGEMTPDD AYQIVHDELM
60 70 80 90 100
LDGNARLNAA TFVTTWMEPQ ADRLMAECFD KNMIDKDEYP QTAEIEARCV
110 120 130 140 150
NILSRLWHAP DARQATGCST TGSSEAAMLG GLALKRRWQR QGRTGRPNLV
160 170 180 190 200
MGINVQVCWE KFANYWDVEM RLVPMDGDRY HLSAEEAVAL CDENTIGVVA
210 220 230 240 250
ILGSTFDGSY EPVAEICAAL DAFQERTGID VPVHVDAASG GFVAPFLDRD
260 270 280 290 300
LVWDFQLPRV SSINVSGHKY GLVYPGVGWI VWRDAQALPE DLIFWVNYLG
310 320 330 340 350
DDMPTFALNF SRPGAQVVAQ YYNFLRLGFA GYARVQGYAR DVATRLAGMI
360 370 380 390 400
ADLGPFELLT RGDELPVFAF KLRDEVTGYS VFDVSEALRE RGWQVPAYTF
410 420 430 440 450
PKNREDLAAL RIVVRRGFTH DLADLLLEDL RRHVQRLEKQ AVPARDATTA

TGFHH
Length:455
Mass (Da):50,910
Last modified:June 13, 2012 - v1
Checksum:iD351A56907B0AF43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012319 Genomic DNA. Translation: BAL89884.1.

Genome annotation databases

EnsemblBacteriaiBAL89884; BAL89884; AMIS_46640.
KEGGiams:AMIS_46640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012319 Genomic DNA. Translation: BAL89884.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAL89884; BAL89884; AMIS_46640.
KEGGiams:AMIS_46640.

Phylogenomic databases

KOiK01580.
OMAiRNADRYP.

Enzyme and pathway databases

BioCyciAMIS512565:GL7J-4713-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC 102363)."
    Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H., Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431Imported.

Entry informationi

Entry nameiI0HA47_ACTM4
AccessioniPrimary (citable) accession number: I0HA47
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: July 22, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.