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I0GYV7

- I0GYV7_ACTM4

UniProt

I0GYV7 - I0GYV7_ACTM4

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Protein
Isocitrate dehydrogenase [NADP]
Gene
AMIS_7240
Organism
Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarity
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei211 – 2111Critical for catalysis By similarityUniRule annotation
Metal bindingi251 – 2511Magnesium or manganese By similarityUniRule annotation
Binding sitei259 – 2591NADP By similarityUniRule annotation
Metal bindingi274 – 2741Magnesium or manganese By similarityUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi309 – 3146NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciAMIS512565:GL7J-744-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:AMIS_7240Imported
OrganismiActinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)Imported
Taxonomic identifieri512565 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeActinoplanes
ProteomesiUP000007882: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiFKDEFQR.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0GYV7-1 [UniParc]FASTAAdd to Basket

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MAKIKVKNPV VEIDGDEMTR IIWKQIREQL VLPYLDVNLE YYDLSIQYRD    50
ETDDQVTIDA ANAIKQHGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR 100
NILGGVVFRE PIIMSNVPRL VPSWTKPIII GRHAHGDQYK ATDFVAPSAG 150
KMTVTFTPAD GSAPMEFVVS DFPAGGVGMA MYNYDESIRD FARASFRYGL 200
ARNYPVYLST KNTILKAYDG RFKDLFAEIF ETEFADQFKA AGLTYEHRLI 250
DDMVAAALKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMTPDGK 300
TVEAEAAHGT VTRHYRQWQK GEKTSTNPIA SIFAWTGGLK HRGKLDGAPE 350
VTQFAETLER VCIETVEGGQ MTKDLALLIA KDAPWLSTDE FMNALDENLA 400
RKLAA 405
Length:405
Mass (Da):45,079
Last modified:June 13, 2012 - v1
Checksum:iFE1D1A3F018B17AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012319 Genomic DNA. Translation: BAL85944.1.
RefSeqiWP_014440841.1. NC_017093.1.
YP_005460460.1. NC_017093.1.

Genome annotation databases

EnsemblBacteriaiBAL85944; BAL85944; AMIS_7240.
GeneIDi12049651.
KEGGiams:AMIS_7240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012319 Genomic DNA. Translation: BAL85944.1 .
RefSeqi WP_014440841.1. NC_017093.1.
YP_005460460.1. NC_017093.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAL85944 ; BAL85944 ; AMIS_7240 .
GeneIDi 12049651.
KEGGi ams:AMIS_7240.

Phylogenomic databases

KOi K00031.
OMAi FKDEFQR.

Enzyme and pathway databases

BioCyci AMIS512565:GL7J-744-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC 102363)."
    Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H., Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431.

Entry informationi

Entry nameiI0GYV7_ACTM4
AccessioniPrimary (citable) accession number: I0GYV7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: September 3, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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