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I0GYV7 (I0GYV7_ACTM4) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding309 – 3146NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity
Binding site2591NADP By similarity PIRSR PIRSR000108-4
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
I0GYV7 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: FE1D1A3F018B17AD

FASTA40545,079
        10         20         30         40         50         60 
MAKIKVKNPV VEIDGDEMTR IIWKQIREQL VLPYLDVNLE YYDLSIQYRD ETDDQVTIDA 

        70         80         90        100        110        120 
ANAIKQHGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR NILGGVVFRE PIIMSNVPRL 

       130        140        150        160        170        180 
VPSWTKPIII GRHAHGDQYK ATDFVAPSAG KMTVTFTPAD GSAPMEFVVS DFPAGGVGMA 

       190        200        210        220        230        240 
MYNYDESIRD FARASFRYGL ARNYPVYLST KNTILKAYDG RFKDLFAEIF ETEFADQFKA 

       250        260        270        280        290        300 
AGLTYEHRLI DDMVAAALKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLMTPDGK 

       310        320        330        340        350        360 
TVEAEAAHGT VTRHYRQWQK GEKTSTNPIA SIFAWTGGLK HRGKLDGAPE VTQFAETLER 

       370        380        390        400 
VCIETVEGGQ MTKDLALLIA KDAPWLSTDE FMNALDENLA RKLAA 

« Hide

References

[1]"Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC 102363)."
Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H., Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP012319 Genomic DNA. Translation: BAL85944.1.
RefSeqYP_005460460.1. NC_017093.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAL85944; BAL85944; AMIS_7240.
GeneID12049651.
KEGGams:AMIS_7240.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.
OMAFKDEFQR.

Enzyme and pathway databases

BioCycAMIS512565:GL7J-744-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI0GYV7_ACTM4
AccessionPrimary (citable) accession number: I0GYV7
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: July 9, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)