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Protein

D-alanine--D-alanine ligase

Gene

CSE_14320

Organism
Caldisericum exile (strain DSM 21853 / NBRC 104410 / AZM16c01)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCEXI511051:GLA9-1482-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:CSE_14320Imported
OrganismiCaldisericum exile (strain DSM 21853 / NBRC 104410 / AZM16c01)Imported
Taxonomic identifieri511051 [NCBI]
Taxonomic lineageiBacteriaCaldisericaCaldisericiaCaldisericalesCaldisericaceaeCaldisericum
ProteomesiUP000004793: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.
OMAiCENDIEL.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0GLC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVGITFNLK RSETELDEFD RPVTIEAIKR ALEARGHKVK LYEATSPLLF
60 70 80 90 100
YSLTIDRPQF VFNIAEGKYG AYREAFVPAL LDELRIPYTG SSVLSLAISM
110 120 130 140 150
DKVMTKEVLL YHGIPTPKFK VLKVIDPIEI GDLNYPVIVK PIFEGSSIGI
160 170 180 190 200
TSKSICENDI ELKEAAEKAF RKFKRPIMVE EFIGGMEVTV GVMGNFPPQV
210 220 230 240 250
LPPMEIDFST LSKRELKASP YIQTYKFKTD YSDKANYYLP ARLPVEVLQK
260 270 280 290 300
ITEIVKNAFI ALRNRDVARF DLRVDKNYNP YILEVNPLPG LDPEHSDLPR
310 320 330
IYKLMGKTYG DLINDILQVA VERYRLETKI SYNHEE
Length:336
Mass (Da):38,441
Last modified:June 13, 2012 - v1
Checksum:i93986DD250E08DF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012051 Genomic DNA. Translation: BAL81558.1.
RefSeqiYP_005473661.1. NC_017096.1.

Genome annotation databases

EnsemblBacteriaiBAL81558; BAL81558; CSE_14320.
GeneIDi12060059.
KEGGicex:CSE_14320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012051 Genomic DNA. Translation: BAL81558.1.
RefSeqiYP_005473661.1. NC_017096.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAL81558; BAL81558; CSE_14320.
GeneIDi12060059.
KEGGicex:CSE_14320.

Phylogenomic databases

KOiK01921.
OMAiCENDIEL.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciCEXI511051:GLA9-1482-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Caldisericum exile AZM16c01."
    Narita-Yamada S., Kawakoshi A., Nakamura S., Sasagawa M., Fukada J., Sekine M., Kato Y., Fukai R., Sasaki K., Hanamaki A., Narita H., Konno Y., Mori K., Yamazaki S., Suzuki K., Fujita N.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21853 / NBRC 104410 / AZM16c01Imported.

Entry informationi

Entry nameiI0GLC1_CALEA
AccessioniPrimary (citable) accession number: I0GLC1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: February 4, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.