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I0FBX3 (I0FBX3_BORCA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Q7M_200 EMBL AFI30979.1
OrganismBorrelia crocidurae (strain Achema) [Complete proteome] [HAMAP] EMBL AFI30979.1
Taxonomic identifier1155096 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain134 – 344211ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding167 – 22256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2971Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3111Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3111Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3131Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I0FBX3 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: 873DF7C69CF8529A

FASTA36441,217
        10         20         30         40         50         60 
MKRNLMLIFG GVSFEHEISL RSAYGIYSSL LKLDKYNVFS VFVDKVTGIW YLLDSVPSSA 

        70         80         90        100        110        120 
ELIKRHTTSI VNFIPGCGIF VNNKSLEIDV IFPIIHGRTG EDGAIQGFVK MMDIPCVGAG 

       130        140        150        160        170        180 
ILGSAISINK YFCKVLLKSF NIPVVSFIGF KKDDYILNKE GIKEDINNKL NYPVIVKPSV 

       190        200        210        220        230        240 
LGSSIGINVA YNVSQIEKYI EEAFEYDLTV VVEKFIKARE IECAVIGNDQ IKIFTPGEII 

       250        260        270        280        290        300 
VQDFIFYDYD AKYSTIPGDS IVFNIPAHLA MKHLLDIKEY AFLTYKYLEL RGMARIDFLI 

       310        320        330        340        350        360 
SKDTNLLYVN EVNTIPGFTD ISMFAKMCEH DGLSYESLVD KLITLAFESY KKRKDKIDFT 


RLES 

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References

[1]"Complete genome sequence of Borrelia crocidurae."
Elbir H., Gimenez G., Robert C., Raoult D., Drancourt M.
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003426 Genomic DNA. Translation: AFI30979.1.
RefSeqYP_006272131.1. NC_017808.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFI30979; AFI30979; Q7M_200.
GeneID12827574.
KEGGbcw:Q7M_200.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI0FBX3_BORCA
AccessionPrimary (citable) accession number: I0FBX3
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: February 19, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)