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I0F597

- I0F597_9BACI

UniProt

I0F597 - I0F597_9BACI

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus sp. JS
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Thiamine pyrophosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBSP1127744:GL8I-2203-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenaseUniRule annotation
    Gene namesi
    Name:odhAUniRule annotation
    ORF Names:MY9_2119Imported
    OrganismiBacillus sp. JSImported
    Taxonomic identifieri1127744 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000005213: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    KOiK00164.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    I0F597-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQNSMKQRM NWEDFYGPNL GYALELYDQY TQDPDSIDPD LKEMFDELGA    50
    PPSELKEASG TKEKGRVTAD LIQKIASAVR LAEDIRTYGH LNASVNPLRK 100
    DGKKSELFPL SDYGLTEEEI KAIPASVICK DAPKNITNGL EAIQYLRNTY 150
    KRTISFEFDH VHDFKEREWL TKMIESGELF QKNSDEKLSA VLERLTEVEG 200
    FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKSGTT SVNIGMAHRG 250
    RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSIGISYG WTGDVKYHLG 300
    ANRELQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQSGYPVQ 350
    DETKSLAILI HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF 400
    TTESAESRST KYASDLAKGY EIPIVHVNAD DPEACLSAVK FAVEYRKTFN 450
    KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHPTVKQ IFAEKLVKEG 500
    VLTEEVVQNI EKSVTKRIED AYQKVPSKKE HIACEIELPE PVSNGFPDVD 550
    TSIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA 600
    ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG EEFVPLHHLS 650
    DCSTSFAVHN SPLSEGSVLG FEYGYNVHSP ETLVLWEAQY GDFANAAQVY 700
    FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRIER FLQLAAENNW 750
    TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNTVSEVQE 800
    LSESRFQPVY EQSGLSHDYE KVTRLVLSSG KVSIDISDHF NKLEDGKEWL 850
    HIARIEQLYP FPAKGVKELF AKLPNLKEIV WVQEEPQNMG AWSYISPYLI 900
    EIAPEGVSVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN 944
    Length:944
    Mass (Da):106,323
    Last modified:June 13, 2012 - v1
    Checksum:i033EB535FAACF7C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003492 Genomic DNA. Translation: AFI28653.1.
    RefSeqiWP_014664273.1. NC_017743.1.
    YP_006231909.1. NC_017743.1.

    Genome annotation databases

    EnsemblBacteriaiAFI28653; AFI28653; MY9_2119.
    GeneIDi12769800.
    KEGGibjs:MY9_2119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003492 Genomic DNA. Translation: AFI28653.1 .
    RefSeqi WP_014664273.1. NC_017743.1.
    YP_006231909.1. NC_017743.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFI28653 ; AFI28653 ; MY9_2119 .
    GeneIDi 12769800.
    KEGGi bjs:MY9_2119.

    Phylogenomic databases

    KOi K00164.

    Enzyme and pathway databases

    BioCyci BSP1127744:GL8I-2203-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome Sequence of the Plant Growth-Promoting Rhizobacterium Bacillus sp. Strain JS."
      Song J.Y., Kim H.A., Kim J.S., Kim S.Y., Jeong H., Kang S.G., Kim B.K., Kwon S.K., Lee C.H., Yu D.S., Kim B.S., Kim S.H., Kwon S.Y., Kim J.F.
      J. Bacteriol. 194:3760-3761(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JSImported.

    Entry informationi

    Entry nameiI0F597_9BACI
    AccessioniPrimary (citable) accession number: I0F597
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3