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I0F597 (I0F597_9BACI) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169

EC=1.2.4.2 HAMAP-Rule MF_01169
Alternative name(s):
Alpha-ketoglutarate dehydrogenase HAMAP-Rule MF_01169
Gene names
Name:odhA HAMAP-Rule MF_01169
ORF Names:MY9_2119 EMBL AFI28653.1
OrganismBacillus sp. JS [Complete proteome] EMBL AFI28653.1
Taxonomic identifier1127744 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. SAAS SAAS023784 HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. SAAS SAAS023784 HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family. HAMAP-Rule MF_01169

Sequences

Sequence LengthMass (Da)Tools
I0F597 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: 033EB535FAACF7C3

FASTA944106,323
        10         20         30         40         50         60 
MFQNSMKQRM NWEDFYGPNL GYALELYDQY TQDPDSIDPD LKEMFDELGA PPSELKEASG 

        70         80         90        100        110        120 
TKEKGRVTAD LIQKIASAVR LAEDIRTYGH LNASVNPLRK DGKKSELFPL SDYGLTEEEI 

       130        140        150        160        170        180 
KAIPASVICK DAPKNITNGL EAIQYLRNTY KRTISFEFDH VHDFKEREWL TKMIESGELF 

       190        200        210        220        230        240 
QKNSDEKLSA VLERLTEVEG FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKSGTT 

       250        260        270        280        290        300 
SVNIGMAHRG RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSIGISYG WTGDVKYHLG 

       310        320        330        340        350        360 
ANRELQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQSGYPVQ DETKSLAILI 

       370        380        390        400        410        420 
HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF TTESAESRST KYASDLAKGY 

       430        440        450        460        470        480 
EIPIVHVNAD DPEACLSAVK FAVEYRKTFN KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD 

       490        500        510        520        530        540 
AVRKHPTVKQ IFAEKLVKEG VLTEEVVQNI EKSVTKRIED AYQKVPSKKE HIACEIELPE 

       550        560        570        580        590        600 
PVSNGFPDVD TSIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA 

       610        620        630        640        650        660 
ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG EEFVPLHHLS DCSTSFAVHN 

       670        680        690        700        710        720 
SPLSEGSVLG FEYGYNVHSP ETLVLWEAQY GDFANAAQVY FDQFISAGRA KWGQKSGLVM 

       730        740        750        760        770        780 
LLPHGYEGQG PEHSSGRIER FLQLAAENNW TVANLTSAAQ YFHILRRQAK MLLREEIRPL 

       790        800        810        820        830        840 
VIMTPKSLLR NPNTVSEVQE LSESRFQPVY EQSGLSHDYE KVTRLVLSSG KVSIDISDHF 

       850        860        870        880        890        900 
NKLEDGKEWL HIARIEQLYP FPAKGVKELF AKLPNLKEIV WVQEEPQNMG AWSYISPYLI 

       910        920        930        940 
EIAPEGVSVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN 

« Hide

References

[1]"Genome Sequence of the Plant Growth-Promoting Rhizobacterium Bacillus sp. Strain JS."
Song J.Y., Kim H.A., Kim J.S., Kim S.Y., Jeong H., Kang S.G., Kim B.K., Kwon S.K., Lee C.H., Yu D.S., Kim B.S., Kim S.H., Kwon S.Y., Kim J.F.
J. Bacteriol. 194:3760-3761(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JS EMBL AFI28653.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003492 Genomic DNA. Translation: AFI28653.1.
RefSeqYP_006231909.1. NC_017743.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFI28653; AFI28653; MY9_2119.
GeneID12769800.
KEGGbjs:MY9_2119.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00164.

Enzyme and pathway databases

BioCycBSP1127744:GL8I-2203-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameI0F597_9BACI
AccessionPrimary (citable) accession number: I0F597
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: June 11, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)