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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus sp. JS
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

Cofactori

thiamine diphosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processGlycolysisUniRule annotationSAAS annotation
LigandThiamine pyrophosphateUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotationSAAS annotation (EC:1.2.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
ORF Names:MY9_2119Imported
OrganismiBacillus sp. JSImported
Taxonomic identifieri1127744 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000005213 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini595 – 791Transket_pyrInterPro annotationAdd BLAST197

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00164.
OrthoDBiPOG091H03SK.

Family and domain databases

HAMAPiMF_01169. SucA_OdhA. 1 hit.
InterProiView protein in InterPro
IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR031717. KGD_C.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiView protein in Pfam
PF00676. E1_dh. 1 hit.
PF16870. OxoGdeHyase_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiView protein in SMART
SM00861. Transket_pyr. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

I0F597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQNSMKQRM NWEDFYGPNL GYALELYDQY TQDPDSIDPD LKEMFDELGA
60 70 80 90 100
PPSELKEASG TKEKGRVTAD LIQKIASAVR LAEDIRTYGH LNASVNPLRK
110 120 130 140 150
DGKKSELFPL SDYGLTEEEI KAIPASVICK DAPKNITNGL EAIQYLRNTY
160 170 180 190 200
KRTISFEFDH VHDFKEREWL TKMIESGELF QKNSDEKLSA VLERLTEVEG
210 220 230 240 250
FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKSGTT SVNIGMAHRG
260 270 280 290 300
RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSIGISYG WTGDVKYHLG
310 320 330 340 350
ANRELQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQSGYPVQ
360 370 380 390 400
DETKSLAILI HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF
410 420 430 440 450
TTESAESRST KYASDLAKGY EIPIVHVNAD DPEACLSAVK FAVEYRKTFN
460 470 480 490 500
KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHPTVKQ IFAEKLVKEG
510 520 530 540 550
VLTEEVVQNI EKSVTKRIED AYQKVPSKKE HIACEIELPE PVSNGFPDVD
560 570 580 590 600
TSIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA
610 620 630 640 650
ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG EEFVPLHHLS
660 670 680 690 700
DCSTSFAVHN SPLSEGSVLG FEYGYNVHSP ETLVLWEAQY GDFANAAQVY
710 720 730 740 750
FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRIER FLQLAAENNW
760 770 780 790 800
TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNTVSEVQE
810 820 830 840 850
LSESRFQPVY EQSGLSHDYE KVTRLVLSSG KVSIDISDHF NKLEDGKEWL
860 870 880 890 900
HIARIEQLYP FPAKGVKELF AKLPNLKEIV WVQEEPQNMG AWSYISPYLI
910 920 930 940
EIAPEGVSVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN
Length:944
Mass (Da):106,323
Last modified:June 13, 2012 - v1
Checksum:i033EB535FAACF7C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003492 Genomic DNA. Translation: AFI28653.1.
RefSeqiWP_014664273.1. NC_017743.1.

Genome annotation databases

EnsemblBacteriaiAFI28653; AFI28653; MY9_2119.
KEGGibjs:MY9_2119.
PATRICifig|1127744.3.peg.2090.

Similar proteinsi

Entry informationi

Entry nameiI0F597_9BACI
AccessioniPrimary (citable) accession number: I0F597
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: September 27, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported