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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus sp. JS
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

Cofactori

thiamine diphosphateUniRule annotationSAAS annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-HAMAP
  2. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

Thiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBSP1127744:GL8I-2203-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotationSAAS annotation (EC:1.2.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
ORF Names:MY9_2119Imported
OrganismiBacillus sp. JSImported
Taxonomic identifieri1127744 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000005213 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

I0F597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQNSMKQRM NWEDFYGPNL GYALELYDQY TQDPDSIDPD LKEMFDELGA
60 70 80 90 100
PPSELKEASG TKEKGRVTAD LIQKIASAVR LAEDIRTYGH LNASVNPLRK
110 120 130 140 150
DGKKSELFPL SDYGLTEEEI KAIPASVICK DAPKNITNGL EAIQYLRNTY
160 170 180 190 200
KRTISFEFDH VHDFKEREWL TKMIESGELF QKNSDEKLSA VLERLTEVEG
210 220 230 240 250
FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKSGTT SVNIGMAHRG
260 270 280 290 300
RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSIGISYG WTGDVKYHLG
310 320 330 340 350
ANRELQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQSGYPVQ
360 370 380 390 400
DETKSLAILI HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF
410 420 430 440 450
TTESAESRST KYASDLAKGY EIPIVHVNAD DPEACLSAVK FAVEYRKTFN
460 470 480 490 500
KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHPTVKQ IFAEKLVKEG
510 520 530 540 550
VLTEEVVQNI EKSVTKRIED AYQKVPSKKE HIACEIELPE PVSNGFPDVD
560 570 580 590 600
TSIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA
610 620 630 640 650
ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG EEFVPLHHLS
660 670 680 690 700
DCSTSFAVHN SPLSEGSVLG FEYGYNVHSP ETLVLWEAQY GDFANAAQVY
710 720 730 740 750
FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRIER FLQLAAENNW
760 770 780 790 800
TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNTVSEVQE
810 820 830 840 850
LSESRFQPVY EQSGLSHDYE KVTRLVLSSG KVSIDISDHF NKLEDGKEWL
860 870 880 890 900
HIARIEQLYP FPAKGVKELF AKLPNLKEIV WVQEEPQNMG AWSYISPYLI
910 920 930 940
EIAPEGVSVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN
Length:944
Mass (Da):106,323
Last modified:June 12, 2012 - v1
Checksum:i033EB535FAACF7C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003492 Genomic DNA. Translation: AFI28653.1.
RefSeqiWP_014664273.1. NC_017743.1.
YP_006231909.1. NC_017743.1.

Genome annotation databases

EnsemblBacteriaiAFI28653; AFI28653; MY9_2119.
KEGGibjs:MY9_2119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003492 Genomic DNA. Translation: AFI28653.1.
RefSeqiWP_014664273.1. NC_017743.1.
YP_006231909.1. NC_017743.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFI28653; AFI28653; MY9_2119.
KEGGibjs:MY9_2119.

Phylogenomic databases

KOiK00164.

Enzyme and pathway databases

BioCyciBSP1127744:GL8I-2203-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome Sequence of the Plant Growth-Promoting Rhizobacterium Bacillus sp. Strain JS."
    Song J.Y., Kim H.A., Kim J.S., Kim S.Y., Jeong H., Kang S.G., Kim B.K., Kwon S.K., Lee C.H., Yu D.S., Kim B.S., Kim S.H., Kwon S.Y., Kim J.F.
    J. Bacteriol. 194:3760-3761(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JSImported.

Entry informationi

Entry nameiI0F597_9BACI
AccessioniPrimary (citable) accession number: I0F597
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2012
Last sequence update: June 12, 2012
Last modified: March 31, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.