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Protein

Isocitrate dehydrogenase [NADP]

Gene

HCD_00140

Organism
Helicobacter cetorum (strain ATCC BAA-540 / MIT 99-5656)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciHCET1163745:GLDY-31-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:HCD_00140Imported
OrganismiHelicobacter cetorum (strain ATCC BAA-540 / MIT 99-5656)Imported
Taxonomic identifieri1163745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000005013 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0EQ41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYNPKFLEK PKEGEEITIE NGKLHVPNNP IIPFIEGDGI GSDITPAMIK
60 70 80 90 100
VVDKAVEKAY KGAKKIAWYE VFVGEKCYNK FKDHKELSPE EQWLLPDTID
110 120 130 140 150
AINHYKVAIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV
160 170 180 190 200
KEPNKVDMVI FRENAEDIYA GVEWAEGSAE AKKLIHFLQD ELKVTKIRFP
210 220 230 240 250
ETSGIGVKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKFTEGAF
260 270 280 290 300
MKWGYALAQK EFGAKVIDKG PWCSIKNPKT GKEIVIKDMI ADAFLQQILL
310 320 330 340 350
RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT
360 370 380 390 400
APKYTGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSSME KAIKSKKVTY
410 420
DFARLMEGAT EVKCSEFADV MIGCM
Length:425
Mass (Da):47,165
Last modified:June 13, 2012 - v1
Checksum:i960DB6FC70A9FB7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003481 Genomic DNA. Translation: AFI05060.1.
RefSeqiWP_014658589.1. NC_017735.1.

Genome annotation databases

EnsemblBacteriaiAFI05060; AFI05060; HCD_00140.
KEGGihcm:HCD_00140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003481 Genomic DNA. Translation: AFI05060.1.
RefSeqiWP_014658589.1. NC_017735.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFI05060; AFI05060; HCD_00140.
KEGGihcm:HCD_00140.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciHCET1163745:GLDY-31-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Helicobacter cetorum strain MIT 99-5656."
    Kersulyte D., Berg D.E.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-540 / MIT 99-5656Imported.

Entry informationi

Entry nameiI0EQ41_HELCM
AccessioniPrimary (citable) accession number: I0EQ41
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: July 22, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.