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I0EQ41

- I0EQ41_HELCM

UniProt

I0EQ41 - I0EQ41_HELCM

Protein

Isocitrate dehydrogenase [NADP]

Gene

HCD_00140

Organism
Helicobacter cetorum (strain ATCC BAA-540 / MIT 99-5656)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciHCET1163745:GLDY-31-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:HCD_00140Imported
    OrganismiHelicobacter cetorum (strain ATCC BAA-540 / MIT 99-5656)Imported
    Taxonomic identifieri1163745 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000005013: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I0EQ41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYNPKFLEK PKEGEEITIE NGKLHVPNNP IIPFIEGDGI GSDITPAMIK    50
    VVDKAVEKAY KGAKKIAWYE VFVGEKCYNK FKDHKELSPE EQWLLPDTID 100
    AINHYKVAIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV 150
    KEPNKVDMVI FRENAEDIYA GVEWAEGSAE AKKLIHFLQD ELKVTKIRFP 200
    ETSGIGVKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKFTEGAF 250
    MKWGYALAQK EFGAKVIDKG PWCSIKNPKT GKEIVIKDMI ADAFLQQILL 300
    RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT 350
    APKYTGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSSME KAIKSKKVTY 400
    DFARLMEGAT EVKCSEFADV MIGCM 425
    Length:425
    Mass (Da):47,165
    Last modified:June 13, 2012 - v1
    Checksum:i960DB6FC70A9FB7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003481 Genomic DNA. Translation: AFI05060.1.
    RefSeqiYP_006220270.1. NC_017735.1.

    Genome annotation databases

    EnsemblBacteriaiAFI05060; AFI05060; HCD_00140.
    GeneIDi12778116.
    KEGGihcm:HCD_00140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003481 Genomic DNA. Translation: AFI05060.1 .
    RefSeqi YP_006220270.1. NC_017735.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFI05060 ; AFI05060 ; HCD_00140 .
    GeneIDi 12778116.
    KEGGi hcm:HCD_00140.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci HCET1163745:GLDY-31-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Helicobacter cetorum strain MIT 99-5656."
      Kersulyte D., Berg D.E.
      Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-540 / MIT 99-5656Imported.

    Entry informationi

    Entry nameiI0EQ41_HELCM
    AccessioniPrimary (citable) accession number: I0EQ41
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3