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I0E534

- I0E534_HELPX

UniProt

I0E534 - I0E534_HELPX

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Protein

Alanine racemase

Gene

HPSH417_04585

Organism
Helicobacter pylori Shi417
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL1163739:GLEQ-898-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:HPSH417_04585Imported
OrganismiHelicobacter pylori Shi417Imported
Taxonomic identifieri1163739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000005009: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI0E534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

I0E534-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKRASFVEV NTASLRHNFS AVKSIVPKDA HIMAVVKANA YGVGAIKASE
60 70 80 90 100
IFLQEGANYL GVATLDEALE LRSYFSKTPI LILGYSPNSN ASMLIDNDLS
110 120 130 140 150
AMIFSLEQAE VFSQTALKSQ KRLKVHLKID TGMHRLGLEP NFKSIEIIKK
160 170 180 190 200
IRALKGLEME GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLNQKIEFQY
210 220 230 240 250
RHAYNSAGIL SLCNGNENRF LNLYRPGIML YGFYPSNGMK ETCPTILKNV
260 270 280 290 300
ISLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLMRALGN
310 320 330 340 350
RIQVAINNQL APLIGKVCMD QCFVKLNNIQ AKEGDEVILF GDKSAKANDA
360 370
SEIAALLNTI PYETISTLSK RLERVYI
Length:377
Mass (Da):41,893
Last modified:June 13, 2012 - v1
Checksum:i0F2EEBA279A5AFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003472 Genomic DNA. Translation: AFH98052.1.
RefSeqiWP_000918003.1. NC_017739.1.
YP_006224546.1. NC_017739.1.

Genome annotation databases

EnsemblBacteriaiAFH98052; AFH98052; HPSH417_04585.
GeneIDi12775303.
KEGGihhr:HPSH417_04585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003472 Genomic DNA. Translation: AFH98052.1 .
RefSeqi WP_000918003.1. NC_017739.1.
YP_006224546.1. NC_017739.1.

3D structure databases

ProteinModelPortali I0E534.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFH98052 ; AFH98052 ; HPSH417_04585 .
GeneIDi 12775303.
KEGGi hhr:HPSH417_04585.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HPYL1163739:GLEQ-898-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Kersulyte D., Cabrera L., Pacheco R., Herrera P., Rodriguez C., Gilman R.H., Berg D.E.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Shi417Imported.

Entry informationi

Entry nameiI0E534_HELPX
AccessioniPrimary (citable) accession number: I0E534
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: November 26, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3