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I0E2M6

- I0E2M6_HELPX

UniProt

I0E2M6 - I0E2M6_HELPX

Protein

Isocitrate dehydrogenase [NADP]

Gene

HPSH417_00120

Organism
Helicobacter pylori Shi417
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 11 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciHPYL1163739:GLEQ-29-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:HPSH417_00120Imported
    OrganismiHelicobacter pylori Shi417Imported
    Taxonomic identifieri1163739 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000005009: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I0E2M6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYNPKILQK PKEGEEITIK DNKLHVPNHP IIPFIEGDGI GSDITPAMIK    50
    VVDSAVQKAY KGEKKIAWYE VFVGEKCYQK FKDHKELSPE EQWLLPDTIE 100
    AINHYKVSIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV 150
    KEPQKVDMVI FRENSEDIYA GIEWQEGSAE AKKLIHFLQN ELKVKKIRFP 200
    ESSGIGVKPI SKEGTERLVR KAIGYAIDND KPSVTFVHKG NIMKYTEGAF 250
    MKWGYALAQK EFNAQVIDKG PWCSLKNPKT GKEIIIKDMI ADAFLQQILL 300
    RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT 350
    APKYAGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY 400
    DFARLMDGAK EVKCSEFASV MIENM 425
    Length:425
    Mass (Da):47,420
    Last modified:June 13, 2012 - v1
    Checksum:i245996612398C85B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003472 Genomic DNA. Translation: AFH97194.1.
    RefSeqiYP_006223688.1. NC_017739.1.

    Genome annotation databases

    EnsemblBacteriaiAFH97194; AFH97194; HPSH417_00120.
    GeneIDi12776024.
    KEGGihhr:HPSH417_00120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003472 Genomic DNA. Translation: AFH97194.1 .
    RefSeqi YP_006223688.1. NC_017739.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFH97194 ; AFH97194 ; HPSH417_00120 .
    GeneIDi 12776024.
    KEGGi hhr:HPSH417_00120.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci HPYL1163739:GLEQ-29-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kersulyte D., Cabrera L., Pacheco R., Herrera P., Rodriguez C., Gilman R.H., Berg D.E.
      Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Shi417Imported.

    Entry informationi

    Entry nameiI0E2M6_HELPX
    AccessioniPrimary (citable) accession number: I0E2M6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3