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I0D2P2 (I0D2P2_BACAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
ORF Names:H9401_2487 EMBL AFH83873.1
OrganismBacillus anthracis str. H9401 [Complete proteome] EMBL AFH83873.1
Taxonomic identifier768494 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain106 – 300195ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding133 – 18856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2551Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2671Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2671Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2691Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I0D2P2 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: 882C3D63951AFAE1

FASTA31134,701
        10         20         30         40         50         60 
MKFGVEEMRI GVIMGGVSSE KQVSIMTGNE MIANLDKNKY EIVPITLNEK MDLIEKAKDI 

        70         80         90        100        110        120 
DFALLALHGK YGEDGTVQGT LESLGIPYSG SNMLSSGICM DKNISKKILR YEGIETPDWI 

       130        140        150        160        170        180 
ELTKMEDLNF DELDKLGFPL VVKPNSGGSS VGVKIVYDKD ELISMLETVF EWDSEVVIEK 

       190        200        210        220        230        240 
YIKGEEITCS IFDGKQLPII SIRHAAEFFD YNAKYDDAST IEEVIELPAE LKERVNKASL 

       250        260        270        280        290        300 
ACYKALKCSV YARVDMMVKD GIPYVMEVNT LPGMTQVSLL PKSADAAGIH YSKLLDMIIE 

       310 
TSLRVRKEEG F 

« Hide

References

[1]"Complete genome sequence of Bacillus anthracis H9401, an isolate from a Korean patient with anthrax."
Chun J.H., Hong K.J., Cha S.H., Cho M.H., Lee K.J., Jeong D.H., Yoo C.K., Rhie G.E.
J. Bacteriol. 194:4116-4117(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H9401 EMBL AFH83873.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002091 Genomic DNA. Translation: AFH83873.1.
RefSeqYP_006209541.1. NC_017729.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFH83873; AFH83873; H9401_2487.
GeneID12788301.
KEGGbax:H9401_2487.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycBANT768494:GL8F-2580-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI0D2P2_BACAN
AccessionPrimary (citable) accession number: I0D2P2
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: April 16, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)