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Protein

Alanine racemase

Gene

B2K_02900

Organism
Paenibacillus mucilaginosus K02
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPMUC997761:GLI6-621-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:B2K_02900Imported
OrganismiPaenibacillus mucilaginosus K02Imported
Taxonomic identifieri997761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000007392 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI0BBD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I0BBD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSFYRPTRV EISLDALRHN IGEFRRVLPE HVRMMAVVKA DAYGHGAVEV
60 70 80 90 100
CREVLQCGVE YIAVAFLDEG LELRKAGITA PILVLGYTPP EGLETAWNHD
110 120 130 140 150
ITLNLYTDEL LDAWERLGPR ERPLRIHIKV DTGMNRIGVT GEEQAVTLIE
160 170 180 190 200
RALGIPALQV EGLFTHYACA DEEDKSYTLQ QYARFQQVVE HFRSRGIEFP
210 220 230 240 250
YVHAGNSAAA IDTPELTYNM VRLGISMYGL YPSDEVMKER VDLQPVLSIK
260 270 280 290 300
TGVVMLKKVL AGEGISYGAV YRPQEEETIA TLPIGYADGF SRMLTGKAYA
310 320 330 340 350
LIRGRRVPIV GRICMDQCMM NVTPLADISS EEEVVILGRQ GSETISAEEH
360 370 380 390
AQWLGTVNYE VVCMISHRVP RMYIRGGQVV STINPLLRHL WERK
Length:394
Mass (Da):44,280
Last modified:June 12, 2012 - v1
Checksum:i91C1C106FB920DEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003422 Genomic DNA. Translation: AFH59683.1.
RefSeqiWP_014649297.1. NC_017672.3.
YP_006187448.1. NC_017672.3.

Genome annotation databases

EnsemblBacteriaiAFH59683; AFH59683; B2K_02900.
KEGGipmw:B2K_02900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003422 Genomic DNA. Translation: AFH59683.1.
RefSeqiWP_014649297.1. NC_017672.3.
YP_006187448.1. NC_017672.3.

3D structure databases

ProteinModelPortaliI0BBD6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFH59683; AFH59683; B2K_02900.
KEGGipmw:B2K_02900.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciPMUC997761:GLI6-621-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Paenibacillus mucilaginosus K02."
    Xiao B., Sun L., Xiao L., Lian B.
    Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: K02Imported.

Entry informationi

Entry nameiI0BBD6_9BACL
AccessioniPrimary (citable) accession number: I0BBD6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2012
Last sequence update: June 12, 2012
Last modified: March 31, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.