I0AQX6 (I0AQX6_CORPS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase [NADP] EMBL AFH51383.1

Gene names

Name:	icd EMBL AFH51383.1
ORF Names:	Cp267_0477 EMBL AFH51383.1

Organism

Corynebacterium pseudotuberculosis 267 EMBL AFH51383.1

Taxonomic identifier

1089446 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › Corynebacterium pseudotuberculosis

Protein attributes

Sequence length	736 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	130 – 137	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	345	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	543	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	547	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	143	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	542	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	252	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	415	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	I0AQX6 [UniParc]. Last modified June 13, 2012. Version 1. Checksum: 39771BB46760A831	FASTA	736	79,816
	10 20 30 40 50 60 MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILSQF PEFLTEDQKV 70 80 90 100 110 120 DDALAELGEL AKTPEANIIK LPNISASVPQ LKAAVTELQS QGYKLPNYPD SPSTEEEKDI 130 140 150 160 170 180 RARYDAVKGS AVNPVLREGN SDRRAPIAVK NFAKKHPHRM GAWSADSKTN VVTMESNDFR 190 200 210 220 230 240 HNEKSVIMPD NDTLTIKLVT DNGEKVLKDG LKVLKGEVVD GTFISARALD EFLADQVKRA 250 260 270 280 290 300 KDEGVLFSAH LKATMMKVSD PIIFGHVVRA YFADVFAKYG EQLEAAGLNG ENGLAAIYSG 310 320 330 340 350 360 LESLPNGAEI KAAFDEALES GADIAMVNSA KGITNLHVPS DVIIDASMPA MIRTSGHMWN 370 380 390 400 410 420 KNDEEQDTLA VIPDSSYAGV YQTVIADCKK NGAFDPTTMG TVPNVGLMAQ KAEEYGSHDK 430 440 450 460 470 480 TFKIEANGTV QVVSSAGEVL IEHNVEAGDI WRACQAKDAP IQDWVKLAVT RSRLSGMPAV 490 500 510 520 530 540 FWLDPERAHD RNLAALVEKY LADHDTEGLD IHIMSPVEAT QFSIDRIRRG EDTISVTGNV 550 560 570 580 590 600 LRDYNTDLFP ILELGTSAKM LSVVPLMAGG GLFETGAGGS APKHVQQLVE ENHLRWDSLG 610 620 630 640 650 660 EFLALAESLR HFANTEGNTK AGILADTLDR ATETLLNEGY SPSRKAGEID NRGSHFFLTK 670 680 690 700 710 720 FWAKELSIQS EDADLAATFT PVAEALETHS EDIADALLAV QGAPADLGGY YHPDDAKTTA 730 VMRPVASYND IISSIK

References

[1]

"Complete Genome Sequence of Corynebacterium pseudotuberculosis Strain Cp267, Isolated from a Llama." Lopes T., Silva A., Thiago R., Carneiro A., Dorella F.A., Rocha F.S., Dos Santos A.R., Lima A.R., Guimaraes L.C., Barbosa E.G., Ribeiro D., Fiaux K.K., Diniz C.A., de Abreu V.A., de Almeida S.S., Hassan S.S., Ali A., Bakhtiar S.M. , Aburjaile F.F., Pinto A.C., Soares Sde C., Pereira Ude P., Schneider M.P., Miyoshi A., Edman J., Spier S., Azevedo V. J. Bacteriol. 194:3567-3568(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 267 EMBL AFH51383.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003407 Genomic DNA. Translation: AFH51383.1.
RefSeq	YP_005843308.1. NC_017462.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AFH51383; AFH51383; Cp267_0477.
GeneID	12450995.
KEGG	cor:Cp267_0477.
Phylogenomic databases
KO	K00031.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

I0AQX6_CORPS

Accession

Primary (citable) accession number: I0AQX6

Entry history

Integrated into UniProtKB/TrEMBL:	June 13, 2012
Last sequence update:	June 13, 2012
Last modified:	April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)