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I0AQX6

- I0AQX6_CORPS

UniProt

I0AQX6 - I0AQX6_CORPS

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Protein
Submitted name:

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Corynebacterium pseudotuberculosis 267
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei252 – 2521Critical for catalysisUniRule annotation
Metal bindingi345 – 3451Magnesium or manganeseUniRule annotation
Sitei415 – 4151Critical for catalysisUniRule annotation
Binding sitei542 – 5421SubstrateUniRule annotation
Metal bindingi543 – 5431Magnesium or manganeseUniRule annotation
Metal bindingi547 – 5471Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCPSE1089446:GLBS-493-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP]Imported
Gene namesi
Name:icdImported
ORF Names:Cp267_0477Imported
OrganismiCorynebacterium pseudotuberculosis 267Imported
Taxonomic identifieri1089446 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000007395: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

I0AQX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILSQF
60 70 80 90 100
PEFLTEDQKV DDALAELGEL AKTPEANIIK LPNISASVPQ LKAAVTELQS
110 120 130 140 150
QGYKLPNYPD SPSTEEEKDI RARYDAVKGS AVNPVLREGN SDRRAPIAVK
160 170 180 190 200
NFAKKHPHRM GAWSADSKTN VVTMESNDFR HNEKSVIMPD NDTLTIKLVT
210 220 230 240 250
DNGEKVLKDG LKVLKGEVVD GTFISARALD EFLADQVKRA KDEGVLFSAH
260 270 280 290 300
LKATMMKVSD PIIFGHVVRA YFADVFAKYG EQLEAAGLNG ENGLAAIYSG
310 320 330 340 350
LESLPNGAEI KAAFDEALES GADIAMVNSA KGITNLHVPS DVIIDASMPA
360 370 380 390 400
MIRTSGHMWN KNDEEQDTLA VIPDSSYAGV YQTVIADCKK NGAFDPTTMG
410 420 430 440 450
TVPNVGLMAQ KAEEYGSHDK TFKIEANGTV QVVSSAGEVL IEHNVEAGDI
460 470 480 490 500
WRACQAKDAP IQDWVKLAVT RSRLSGMPAV FWLDPERAHD RNLAALVEKY
510 520 530 540 550
LADHDTEGLD IHIMSPVEAT QFSIDRIRRG EDTISVTGNV LRDYNTDLFP
560 570 580 590 600
ILELGTSAKM LSVVPLMAGG GLFETGAGGS APKHVQQLVE ENHLRWDSLG
610 620 630 640 650
EFLALAESLR HFANTEGNTK AGILADTLDR ATETLLNEGY SPSRKAGEID
660 670 680 690 700
NRGSHFFLTK FWAKELSIQS EDADLAATFT PVAEALETHS EDIADALLAV
710 720 730
QGAPADLGGY YHPDDAKTTA VMRPVASYND IISSIK
Length:736
Mass (Da):79,816
Last modified:June 13, 2012 - v1
Checksum:i39771BB46760A831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003407 Genomic DNA. Translation: AFH51383.1.
RefSeqiYP_005843308.1. NC_017462.1.

Genome annotation databases

EnsemblBacteriaiAFH51383; AFH51383; Cp267_0477.
GeneIDi12450995.
KEGGicor:Cp267_0477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003407 Genomic DNA. Translation: AFH51383.1 .
RefSeqi YP_005843308.1. NC_017462.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFH51383 ; AFH51383 ; Cp267_0477 .
GeneIDi 12450995.
KEGGi cor:Cp267_0477.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci CPSE1089446:GLBS-493-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 267Imported.

Entry informationi

Entry nameiI0AQX6_CORPS
AccessioniPrimary (citable) accession number: I0AQX6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: November 26, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3