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I0AEW9 (I0AEW9_SALET) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 7. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP-Rule MF_00116
Short name=dUTPase HAMAP-Rule MF_00116
EC=3.6.1.23 HAMAP-Rule MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP-Rule MF_00116
Gene names
Name:dut HAMAP-Rule MF_00116
ORF Names:SU5_04208 EMBL AFH47526.1
OrganismSalmonella enterica subsp. enterica serovar Heidelberg str. B182 EMBL AFH47526.1
Taxonomic identifier1160717 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length152 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. SAAS SAAS008181 HAMAP-Rule MF_00116

Catalytic activity

dUTP + H2O = dUMP + diphosphate. SAAS SAAS008181 HAMAP-Rule MF_00116

Cofactor

Magnesium By similarity. SAAS SAAS008181 HAMAP-Rule MF_00116

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP-Rule MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP-Rule MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region71 – 733Substrate binding By similarity HAMAP-Rule MF_00116
Region88 – 903Substrate binding By similarity HAMAP-Rule MF_00116

Sites

Binding site841Substrate By similarity HAMAP-Rule MF_00116
Binding site981Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00116

Sequences

Sequence LengthMass (Da)Tools
I0AEW9 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: A3524F74748CE1F2

FASTA15216,168
        10         20         30         40         50         60 
MMKKIDVKIL DPRVGQQFPL PTYATSGSAG LDLRACLDDA VELAPGATTL VPTGLAIHIA 

        70         80         90        100        110        120 
DPSLAAVMLP RSGLGHKHGI VLGNLVGLID SDYQGQLMVS IWNRGQDSFT IEPGERIAQM 

       130        140        150 
VFVPVVQAEF NLVEAFDATE RGEGGFGHSG RK

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References

[1]"Complete Genome Sequence of the Strong Mutator Salmonella enterica subsp. enterica Serotype Heidelberg Strain B182."
Le Bars H., Bousarghin L., Bonnaure-Mallet M., Jolivet-Gougeon A., Barloy-Hubler F.
J. Bacteriol. 194:3537-3538(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B182 EMBL AFH47526.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003416 Genomic DNA. Translation: AFH47526.1.
RefSeqYP_006089803.1. NC_017623.1.

3D structure databases

ProteinModelPortalI0AEW9.
SMRI0AEW9. Positions 1-139.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFH47526; AFH47526; SU5_04208.
GeneID12712422.
KEGGshb:SU5_04208.

Phylogenomic databases

KOK01520.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameI0AEW9_SALET
AccessionPrimary (citable) accession number: I0AEW9
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: April 3, 2013
This is version 7 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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