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H9ZZY7

- H9ZZY7_FERFK

UniProt

H9ZZY7 - H9ZZY7_FERFK

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Protein

DNA ligase

Gene
lig, FFONT_0304
Organism
Fervidicoccus fontis (strain DSM 19380 / VKM B-2539 / Kam940)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei260 – 2601ATP By similarityUniRule annotation
Active sitei262 – 2621N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei267 – 2671ATP By similarityUniRule annotation
Binding sitei282 – 2821ATP By similarityUniRule annotation
Binding sitei312 – 3121ATP By similarityUniRule annotation
Binding sitei352 – 3521ATP By similarityUniRule annotation
Binding sitei429 – 4291ATP By similarityUniRule annotation
Binding sitei435 – 4351ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFFON1163730:GLD9-313-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:FFONT_0304Imported
OrganismiFervidicoccus fontis (strain DSM 19380 / VKM B-2539 / Kam940)Imported
Taxonomic identifieri1163730 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiFervidicoccalesFervidicoccaceaeFervidicoccus
ProteomesiUP000007391: Chromosome

Structurei

3D structure databases

ProteinModelPortaliH9ZZY7.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H9ZZY7-1 [UniParc]FASTAAdd to Basket

« Hide

MDFEIIARTF DALEKISSRI ALTNALVDLF KQTSKDEVKI VVYLIQGRLW    50
PDWKGMPEIG VAEKLLIKAA SIALNVKEEQ INKIYKEVGD LGKAIEQIKA 100
SKDATAGTLT SFLGVQKKEK LSVKKIYESF VKIATAEGEG SRDIKLRVLA 150
GLLKDAQPIE ARFIVRFVEG RLRINIGDAT VMDALSIAFT GTDANRPIIE 200
RAYNLRADLG DIAEILVKDG INALQNITPK VGIPIRPMLA ERHNDPKVML 250
EKVGGKAYVE YKYDGERAQI HKSNDEITIF SRRLENITHQ YPDVVEYSRK 300
YIKANEAIVE GEIVAIDPDT RELRPFQILM TRKRKHDITK MMKEVPVSVF 350
LFDAIYVDGK DLTNFPLPER RKYLESVIAQ SDDMQIAQYK YIDNAEDLEK 400
MFYEAISNGA EGVMIKSISE KSIYQAGNRG WLWIKYKRDY RSEMSDSVDL 450
VVVGAFYGKG KRAGKLSTIL VAGYDPDADV FRTVCKVGTG FTDEELDKMT 500
EEFKGYIIDH KDPRVISEIT PDVWLIPKKV VEVIGAELTL SPLHTCAKGE 550
ISKEAGLSIR FPRFINWRPD KGPEDATTCK ELVEMYRMQL KQVEEEQNP 599
Length:599
Mass (Da):67,836
Last modified:June 13, 2012 - v1
Checksum:i573DF58B5B061B2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003423 Genomic DNA. Translation: AFH42294.1.
RefSeqiYP_005841746.1. NC_017461.1.

Genome annotation databases

EnsemblBacteriaiAFH42294; AFH42294; FFONT_0304.
GeneIDi12449374.
KEGGiffo:FFONT_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003423 Genomic DNA. Translation: AFH42294.1 .
RefSeqi YP_005841746.1. NC_017461.1.

3D structure databases

ProteinModelPortali H9ZZY7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFH42294 ; AFH42294 ; FFONT_0304 .
GeneIDi 12449374.
KEGGi ffo:FFONT_0304.

Phylogenomic databases

KOi K10747.

Enzyme and pathway databases

BioCyci FFON1163730:GLD9-313-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function."
    Lebedinsky A.V., Mardanov A.V., Gumerov V.M., Beletsky A.V., Kublanov I.V., Perevalova A.A., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19380 / VKM B-2539 / Kam940.

Entry informationi

Entry nameiH9ZZY7_FERFK
AccessioniPrimary (citable) accession number: H9ZZY7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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