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H9ZZY7

- H9ZZY7_FERFK

UniProt

H9ZZY7 - H9ZZY7_FERFK

Protein

DNA ligase

Gene

lig

Organism
Fervidicoccus fontis (strain DSM 19380 / VKM B-2539 / Kam940)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei260 – 2601ATPUniRule annotation
    Active sitei262 – 2621N6-AMP-lysine intermediateUniRule annotation
    Binding sitei267 – 2671ATPUniRule annotation
    Binding sitei282 – 2821ATPUniRule annotation
    Binding sitei312 – 3121ATPUniRule annotation
    Binding sitei352 – 3521ATPUniRule annotation
    Binding sitei429 – 4291ATPUniRule annotation
    Binding sitei435 – 4351ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFFON1163730:GLD9-313-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:FFONT_0304Imported
    OrganismiFervidicoccus fontis (strain DSM 19380 / VKM B-2539 / Kam940)Imported
    Taxonomic identifieri1163730 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiFervidicoccalesFervidicoccaceaeFervidicoccus
    ProteomesiUP000007391: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliH9ZZY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H9ZZY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFEIIARTF DALEKISSRI ALTNALVDLF KQTSKDEVKI VVYLIQGRLW    50
    PDWKGMPEIG VAEKLLIKAA SIALNVKEEQ INKIYKEVGD LGKAIEQIKA 100
    SKDATAGTLT SFLGVQKKEK LSVKKIYESF VKIATAEGEG SRDIKLRVLA 150
    GLLKDAQPIE ARFIVRFVEG RLRINIGDAT VMDALSIAFT GTDANRPIIE 200
    RAYNLRADLG DIAEILVKDG INALQNITPK VGIPIRPMLA ERHNDPKVML 250
    EKVGGKAYVE YKYDGERAQI HKSNDEITIF SRRLENITHQ YPDVVEYSRK 300
    YIKANEAIVE GEIVAIDPDT RELRPFQILM TRKRKHDITK MMKEVPVSVF 350
    LFDAIYVDGK DLTNFPLPER RKYLESVIAQ SDDMQIAQYK YIDNAEDLEK 400
    MFYEAISNGA EGVMIKSISE KSIYQAGNRG WLWIKYKRDY RSEMSDSVDL 450
    VVVGAFYGKG KRAGKLSTIL VAGYDPDADV FRTVCKVGTG FTDEELDKMT 500
    EEFKGYIIDH KDPRVISEIT PDVWLIPKKV VEVIGAELTL SPLHTCAKGE 550
    ISKEAGLSIR FPRFINWRPD KGPEDATTCK ELVEMYRMQL KQVEEEQNP 599
    Length:599
    Mass (Da):67,836
    Last modified:June 13, 2012 - v1
    Checksum:i573DF58B5B061B2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003423 Genomic DNA. Translation: AFH42294.1.
    RefSeqiYP_005841746.1. NC_017461.1.

    Genome annotation databases

    EnsemblBacteriaiAFH42294; AFH42294; FFONT_0304.
    GeneIDi12449374.
    KEGGiffo:FFONT_0304.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003423 Genomic DNA. Translation: AFH42294.1 .
    RefSeqi YP_005841746.1. NC_017461.1.

    3D structure databases

    ProteinModelPortali H9ZZY7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFH42294 ; AFH42294 ; FFONT_0304 .
    GeneIDi 12449374.
    KEGGi ffo:FFONT_0304.

    Phylogenomic databases

    KOi K10747.

    Enzyme and pathway databases

    BioCyci FFON1163730:GLD9-313-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function."
      Lebedinsky A.V., Mardanov A.V., Gumerov V.M., Beletsky A.V., Kublanov I.V., Perevalova A.A., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
      Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 19380 / VKM B-2539 / Kam940Imported.

    Entry informationi

    Entry nameiH9ZZY7_FERFK
    AccessioniPrimary (citable) accession number: H9ZZY7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3