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Protein

DNA ligase

Gene

lig

Organism
Fervidicoccus fontis (strain DSM 19380 / VKM B-2539 / Kam940)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei260 – 2601ATPUniRule annotation
Active sitei262 – 2621N6-AMP-lysine intermediateUniRule annotation
Binding sitei267 – 2671ATPUniRule annotation
Binding sitei282 – 2821ATPUniRule annotation
Binding sitei312 – 3121ATPUniRule annotation
Binding sitei352 – 3521ATPUniRule annotation
Binding sitei429 – 4291ATPUniRule annotation
Binding sitei435 – 4351ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFFON1163730:GLD9-313-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:FFONT_0304Imported
OrganismiFervidicoccus fontis (strain DSM 19380 / VKM B-2539 / Kam940)Imported
Taxonomic identifieri1163730 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiFervidicoccalesFervidicoccaceaeFervidicoccus
ProteomesiUP000007391 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliH9ZZY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H9ZZY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFEIIARTF DALEKISSRI ALTNALVDLF KQTSKDEVKI VVYLIQGRLW
60 70 80 90 100
PDWKGMPEIG VAEKLLIKAA SIALNVKEEQ INKIYKEVGD LGKAIEQIKA
110 120 130 140 150
SKDATAGTLT SFLGVQKKEK LSVKKIYESF VKIATAEGEG SRDIKLRVLA
160 170 180 190 200
GLLKDAQPIE ARFIVRFVEG RLRINIGDAT VMDALSIAFT GTDANRPIIE
210 220 230 240 250
RAYNLRADLG DIAEILVKDG INALQNITPK VGIPIRPMLA ERHNDPKVML
260 270 280 290 300
EKVGGKAYVE YKYDGERAQI HKSNDEITIF SRRLENITHQ YPDVVEYSRK
310 320 330 340 350
YIKANEAIVE GEIVAIDPDT RELRPFQILM TRKRKHDITK MMKEVPVSVF
360 370 380 390 400
LFDAIYVDGK DLTNFPLPER RKYLESVIAQ SDDMQIAQYK YIDNAEDLEK
410 420 430 440 450
MFYEAISNGA EGVMIKSISE KSIYQAGNRG WLWIKYKRDY RSEMSDSVDL
460 470 480 490 500
VVVGAFYGKG KRAGKLSTIL VAGYDPDADV FRTVCKVGTG FTDEELDKMT
510 520 530 540 550
EEFKGYIIDH KDPRVISEIT PDVWLIPKKV VEVIGAELTL SPLHTCAKGE
560 570 580 590
ISKEAGLSIR FPRFINWRPD KGPEDATTCK ELVEMYRMQL KQVEEEQNP
Length:599
Mass (Da):67,836
Last modified:June 13, 2012 - v1
Checksum:i573DF58B5B061B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003423 Genomic DNA. Translation: AFH42294.1.
RefSeqiWP_014557443.1. NC_017461.1.
YP_005841746.1. NC_017461.1.

Genome annotation databases

EnsemblBacteriaiAFH42294; AFH42294; FFONT_0304.
GeneIDi12449374.
KEGGiffo:FFONT_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003423 Genomic DNA. Translation: AFH42294.1.
RefSeqiWP_014557443.1. NC_017461.1.
YP_005841746.1. NC_017461.1.

3D structure databases

ProteinModelPortaliH9ZZY7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFH42294; AFH42294; FFONT_0304.
GeneIDi12449374.
KEGGiffo:FFONT_0304.

Phylogenomic databases

KOiK10747.
OMAiPQVVIEV.

Enzyme and pathway databases

BioCyciFFON1163730:GLD9-313-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function."
    Lebedinsky A.V., Mardanov A.V., Gumerov V.M., Beletsky A.V., Kublanov I.V., Perevalova A.A., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19380 / VKM B-2539 / Kam940Imported.

Entry informationi

Entry nameiH9ZZY7_FERFK
AccessioniPrimary (citable) accession number: H9ZZY7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: April 29, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.