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Protein

DNA ligase

Gene

lig

Organism
Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei260ATPUniRule annotation1
Active sitei262N6-AMP-lysine intermediateUniRule annotation1
Binding sitei267ATPUniRule annotation1
Binding sitei282ATPUniRule annotation1
Binding sitei312ATPUniRule annotation1
Binding sitei352ATPUniRule annotation1
Binding sitei429ATPUniRule annotation1
Binding sitei435ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:FFONT_0304Imported
OrganismiFervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)Imported
Taxonomic identifieri1163730 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiFervidicoccalesFervidicoccaceaeFervidicoccus
Proteomesi
  • UP000007391 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliH9ZZY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 475DNA_LIGASE_A3InterPro annotationAdd BLAST136

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili576 – 596Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

H9ZZY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFEIIARTF DALEKISSRI ALTNALVDLF KQTSKDEVKI VVYLIQGRLW
60 70 80 90 100
PDWKGMPEIG VAEKLLIKAA SIALNVKEEQ INKIYKEVGD LGKAIEQIKA
110 120 130 140 150
SKDATAGTLT SFLGVQKKEK LSVKKIYESF VKIATAEGEG SRDIKLRVLA
160 170 180 190 200
GLLKDAQPIE ARFIVRFVEG RLRINIGDAT VMDALSIAFT GTDANRPIIE
210 220 230 240 250
RAYNLRADLG DIAEILVKDG INALQNITPK VGIPIRPMLA ERHNDPKVML
260 270 280 290 300
EKVGGKAYVE YKYDGERAQI HKSNDEITIF SRRLENITHQ YPDVVEYSRK
310 320 330 340 350
YIKANEAIVE GEIVAIDPDT RELRPFQILM TRKRKHDITK MMKEVPVSVF
360 370 380 390 400
LFDAIYVDGK DLTNFPLPER RKYLESVIAQ SDDMQIAQYK YIDNAEDLEK
410 420 430 440 450
MFYEAISNGA EGVMIKSISE KSIYQAGNRG WLWIKYKRDY RSEMSDSVDL
460 470 480 490 500
VVVGAFYGKG KRAGKLSTIL VAGYDPDADV FRTVCKVGTG FTDEELDKMT
510 520 530 540 550
EEFKGYIIDH KDPRVISEIT PDVWLIPKKV VEVIGAELTL SPLHTCAKGE
560 570 580 590
ISKEAGLSIR FPRFINWRPD KGPEDATTCK ELVEMYRMQL KQVEEEQNP
Length:599
Mass (Da):67,836
Last modified:June 13, 2012 - v1
Checksum:i573DF58B5B061B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003423 Genomic DNA Translation: AFH42294.1

Genome annotation databases

EnsemblBacteriaiAFH42294; AFH42294; FFONT_0304
KEGGiffo:FFONT_0304

Similar proteinsi

Entry informationi

Entry nameiH9ZZY7_FERFK
AccessioniPrimary (citable) accession number: H9ZZY7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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