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H9ZTH0

- H9ZTH0_THETH

UniProt

H9ZTH0 - H9ZTH0_THETH

Protein

Alanine racemase

Gene

TtJL18_1761

Organism
Thermus thermophilus JL-18
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei43 – 431Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei303 – 3031Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTTHE798128:GLMF-1760-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    ORF Names:TtJL18_1761Imported
    OrganismiThermus thermophilus JL-18Imported
    Taxonomic identifieri798128 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000007388: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliH9ZTH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H9ZTH0-1 [UniParc]FASTAAdd to Basket

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    MRPRGYPKGV QARAWIEVDL AALWANYRLL AGRAGGEVIP VLKADAYGHG    50
    ALPLARFLEG KGVGRFAVAT LEEGRRLREG GIKGEVLLLG SLHPLEAEEA 100
    LELGLVPTLS TLEAAEALSL RARALGLVPR AHLKVDTGMN RVGFPWEEAA 150
    SALRAVEAMG VRVEGVYTHL ATAGEDAAFV ETQRRRFQEV RRALGENYFY 200
    HLENSLGLLR HGATAGVRVG LALYGLVPGF GLRPILRILA RPTLVKRLKA 250
    GDRVGYGGVY VARGGEWLAT LPVGYADGLP WGAVRFVKGP DGRLLEVAGR 300
    ISMDQTTVLL PGPVGLEAVF EVLSADFGPT GLLAWAEARG TLPYEVAVHL 350
    SRRLPRRYLE 360
    Length:360
    Mass (Da):38,856
    Last modified:June 13, 2012 - v1
    Checksum:i1122843A02FEF2DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003252 Genomic DNA. Translation: AFH39630.1.
    RefSeqiYP_006059416.1. NC_017587.1.

    Genome annotation databases

    EnsemblBacteriaiAFH39630; AFH39630; TtJL18_1761.
    GeneIDi12654435.
    KEGGittl:TtJL18_1761.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003252 Genomic DNA. Translation: AFH39630.1 .
    RefSeqi YP_006059416.1. NC_017587.1.

    3D structure databases

    ProteinModelPortali H9ZTH0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFH39630 ; AFH39630 ; TtJL18_1761 .
    GeneIDi 12654435.
    KEGGi ttl:TtJL18_1761.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TTHE798128:GLMF-1760-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JL-18Imported.

    Entry informationi

    Entry nameiH9ZTH0_THETH
    AccessioniPrimary (citable) accession number: H9ZTH0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3