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H9ZTH0

- H9ZTH0_THETH

UniProt

H9ZTH0 - H9ZTH0_THETH

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Protein
Alanine racemase
Gene
TtJL18_1761
Organism
Thermus thermophilus JL-18
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei141 – 1411Substrate By similarityUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei303 – 3031Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTTHE798128:GLMF-1760-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:TtJL18_1761Imported
OrganismiThermus thermophilus JL-18Imported
Taxonomic identifieri798128 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000007388: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH9ZTH0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

H9ZTH0-1 [UniParc]FASTAAdd to Basket

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MRPRGYPKGV QARAWIEVDL AALWANYRLL AGRAGGEVIP VLKADAYGHG    50
ALPLARFLEG KGVGRFAVAT LEEGRRLREG GIKGEVLLLG SLHPLEAEEA 100
LELGLVPTLS TLEAAEALSL RARALGLVPR AHLKVDTGMN RVGFPWEEAA 150
SALRAVEAMG VRVEGVYTHL ATAGEDAAFV ETQRRRFQEV RRALGENYFY 200
HLENSLGLLR HGATAGVRVG LALYGLVPGF GLRPILRILA RPTLVKRLKA 250
GDRVGYGGVY VARGGEWLAT LPVGYADGLP WGAVRFVKGP DGRLLEVAGR 300
ISMDQTTVLL PGPVGLEAVF EVLSADFGPT GLLAWAEARG TLPYEVAVHL 350
SRRLPRRYLE 360
Length:360
Mass (Da):38,856
Last modified:June 13, 2012 - v1
Checksum:i1122843A02FEF2DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003252 Genomic DNA. Translation: AFH39630.1.
RefSeqiYP_006059416.1. NC_017587.1.

Genome annotation databases

EnsemblBacteriaiAFH39630; AFH39630; TtJL18_1761.
GeneIDi12654435.
KEGGittl:TtJL18_1761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003252 Genomic DNA. Translation: AFH39630.1 .
RefSeqi YP_006059416.1. NC_017587.1.

3D structure databases

ProteinModelPortali H9ZTH0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFH39630 ; AFH39630 ; TtJL18_1761 .
GeneIDi 12654435.
KEGGi ttl:TtJL18_1761.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TTHE798128:GLMF-1760-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JL-18Imported.

Entry informationi

Entry nameiH9ZTH0_THETH
AccessioniPrimary (citable) accession number: H9ZTH0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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